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Oxsm 3-oxoacyl-ACP synthase, mitochondrial [ Mus musculus (house mouse) ]

Gene ID: 71147, updated on 21-Apr-2024

Summary

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Official Symbol
Oxsmprovided by MGI
Official Full Name
3-oxoacyl-ACP synthase, mitochondrialprovided by MGI
Primary source
MGI:MGI:1918397
See related
Ensembl:ENSMUSG00000021786 AllianceGenome:MGI:1918397
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4933425A18Rik
Summary
Predicted to enable 3-oxoacyl-[acyl-carrier-protein] synthase activity. Predicted to be involved in acyl-CoA metabolic process; medium-chain fatty acid biosynthetic process; and short-chain fatty acid biosynthetic process. Predicted to act upstream of or within fatty acid metabolic process. Located in mitochondrion. Is expressed in dorsal root ganglion; lung; nervous system; peripheral nervous system; and respiratory system. Orthologous to human OXSM (3-oxoacyl-ACP synthase, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 4.1), testis adult (RPKM 3.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 A1; 14 7.08 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (6219955..6231111)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (16238652..16249808, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene retinoic acid receptor, beta Neighboring gene STARR-seq mESC enhancer starr_36026 Neighboring gene predicted gene, 53820 Neighboring gene predicted gene, 46442 Neighboring gene STARR-seq mESC enhancer starr_36025 Neighboring gene STARR-positive B cell enhancer ABC_E1166 Neighboring gene STARR-seq mESC enhancer starr_36024 Neighboring gene topoisomerase (DNA) II beta Neighboring gene STARR-seq mESC enhancer starr_36023 Neighboring gene STARR-seq mESC enhancer starr_36022 Neighboring gene N-glycanase 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:17005903-17006137 Neighboring gene ribosomal protein L31, pseudogene 3 Neighboring gene ribosomal protein L4 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Reduction of mitochondrial 3-oxoacyl-ACP synthase (OXSM) by hyperglycemia is associated with deficiency of α-lipoic acid synthetic pathway in kidney of diabetic mice. Gao T, et al. Biochem Biophys Res Commun, 2019 Apr 23. PMID 30871779
  2. Cloning, expression, and characterization of the human mitochondrial beta-ketoacyl synthase. Complementation of the yeast CEM1 knock-out strain. Zhang L, et al. J Biol Chem, 2005 Apr 1. PMID 15668256
  3. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3-oxoacyl-[acyl-carrier-protein] synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3-oxoacyl-[acyl-carrier-protein] synthase activity ISO
Inferred from Sequence Orthology
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in acyl-CoA metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in medium-chain fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in short-chain fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial
Names
beta-ketoacyl-ACP synthase
NP_001346811.1
NP_001346812.1
NP_081971.1
XP_006518164.1
XP_006518165.1
XP_006518166.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359882.1 → NP_001346811.1  3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial precursor

    Status: VALIDATED

    Source sequence(s)
    AC173482, AK016905, AK034243, BG229916
    Consensus CDS
    CCDS26831.1
    UniProtKB/Swiss-Prot
    Q9D404
    UniProtKB/TrEMBL
    Q148P2
    Conserved Domains (1) summary
    cd00834
    Location:42 → 456
    KAS_I_II; Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen ...

  2. NM_001359883.1 → NP_001346812.1  3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial precursor

    Status: VALIDATED

    Source sequence(s)
    AC173482, AK034243, AK084829, BG229916
    Consensus CDS
    CCDS26831.1
    UniProtKB/Swiss-Prot
    Q9D404
    UniProtKB/TrEMBL
    Q148P2
    Related
    ENSMUSP00000108244.2, ENSMUST00000112625.9
    Conserved Domains (1) summary
    cd00834
    Location:42 → 456
    KAS_I_II; Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen ...

  3. NM_027695.4 → NP_081971.1  3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_081971.1

    Status: VALIDATED

    Source sequence(s)
    AC173482, AK034243, AK083617, BG229916
    Consensus CDS
    CCDS26831.1
    UniProtKB/Swiss-Prot
    Q9D404
    UniProtKB/TrEMBL
    Q148P2
    Related
    ENSMUSP00000022311.5, ENSMUST00000022311.12
    Conserved Domains (1) summary
    cd00834
    Location:42 → 456
    KAS_I_II; Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    6219955..6231111
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518101.4 → XP_006518164.1  3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006518164.1

    UniProtKB/Swiss-Prot
    Q9D404
    UniProtKB/TrEMBL
    Q148P2
    Related
    ENSMUSP00000108243.2, ENSMUST00000112624.3
    Conserved Domains (1) summary
    cd00834
    Location:42 → 456
    KAS_I_II; Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen ...

  2. XM_006518103.5 → XP_006518166.1  3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006518166.1

    UniProtKB/Swiss-Prot
    Q9D404
    UniProtKB/TrEMBL
    Q148P2
    Conserved Domains (1) summary
    cd00834
    Location:42 → 456
    KAS_I_II; Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen ...

  3. XM_006518102.2 → XP_006518165.1  3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006518165.1

    UniProtKB/Swiss-Prot
    Q9D404
    UniProtKB/TrEMBL
    Q148P2
    Conserved Domains (1) summary
    cd00834
    Location:42 → 456
    KAS_I_II; Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D404.1 GenPept UniProtKB/Swiss-Prot:Q9D404

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