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Sh2d6 SH2 domain containing 6 [ Mus musculus (house mouse) ]

Gene ID: 71130, updated on 11-Apr-2024

Summary

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Official Symbol
Sh2d6provided by MGI
Official Full Name
SH2 domain containing 6provided by MGI
Primary source
MGI:MGI:1918380
See related
Ensembl:ENSMUSG00000052631 AllianceGenome:MGI:1918380
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to be involved in intracellular signal transduction and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to be active in cytoplasm. Orthologous to human SH2D6 (SH2 domain containing 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 14.4), duodenum adult (RPKM 4.1) and 6 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 C1; 6 32.27 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (72490624..72511180, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (72513641..72534206, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2789 Neighboring gene gamma-glutamyl carboxylase Neighboring gene STARR-positive B cell enhancer ABC_E6440 Neighboring gene methionine adenosyltransferase 2A Neighboring gene promoter of Mat2a antisense radiation induced circulating long non-coding RNA Neighboring gene STARR-seq mESC enhancer starr_16285 Neighboring gene STARR-seq mESC enhancer starr_16286 Neighboring gene STARR-seq mESC enhancer starr_16287 Neighboring gene STARR-positive B cell enhancer ABC_E11320 Neighboring gene STARR-seq mESC enhancer starr_16289 Neighboring gene STARR-positive B cell enhancer ABC_E6442 Neighboring gene capping actin protein, gelsolin like Neighboring gene ELMO/CED-12 domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E4833

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype. Gineste C, et al. Neuromuscul Disord, 2013 Apr. PMID 23375831
  2. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Homology

Clone Names

  • MGC118386, 4933424C13Rik

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
SH2 domain-containing protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001374030.1 → NP_001360959.1  SH2 domain-containing protein 6

    Status: VALIDATED

    Source sequence(s)
    AC154002
    Consensus CDS
    CCDS90061.1
    UniProtKB/TrEMBL
    A0A3Q4EGG3, E0CYY5, E2QRQ0
    Related
    ENSMUSP00000157110.2, ENSMUST00000234038.2
    Conserved Domains (1) summary
    cl15255
    Location:128 → 249
    SH2; Src homology 2 (SH2) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    72490624..72511180 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241547.4 → XP_011239849.1  SH2 domain-containing protein 6 isoform X2

    See identical proteins and their annotated locations for XP_011239849.1

    Conserved Domains (1) summary
    cl15255
    Location:262 → 383
    SH2; Src homology 2 (SH2) domain

  2. XM_011241544.4 → XP_011239846.2  SH2 domain-containing protein 6 isoform X1

    Conserved Domains (1) summary
    cl15255
    Location:262 → 355
    SH2; Src homology 2 (SH2) domain

  3. XM_011241546.3 → XP_011239848.1  SH2 domain-containing protein 6 isoform X2

    See identical proteins and their annotated locations for XP_011239848.1

    Conserved Domains (1) summary
    cl15255
    Location:262 → 383
    SH2; Src homology 2 (SH2) domain

  4. XM_355785.8 → XP_355785.4  SH2 domain-containing protein 6 isoform X3

    See identical proteins and their annotated locations for XP_355785.4

    UniProtKB/Swiss-Prot
    Q497J3, Q9D413
    UniProtKB/TrEMBL
    A0A3Q4ECA8
    Related
    ENSMUSP00000157379.2, ENSMUST00000234615.2
    Conserved Domains (1) summary
    cl15255
    Location:235 → 356
    SH2; Src homology 2 (SH2) domain

  5. XM_006506834.5 → XP_006506897.1  SH2 domain-containing protein 6 isoform X5

    See identical proteins and their annotated locations for XP_006506897.1

    UniProtKB/TrEMBL
    A0A3Q4EGG3, E0CYY5, E2QRQ0
    Related
    ENSMUSP00000123776.2, ENSMUST00000159877.3
    Conserved Domains (1) summary
    cl15255
    Location:128 → 249
    SH2; Src homology 2 (SH2) domain

  6. XM_011241549.4 → XP_011239851.1  SH2 domain-containing protein 6 isoform X4

    See identical proteins and their annotated locations for XP_011239851.1

  7. XM_036152305.1 → XP_036008198.1  SH2 domain-containing protein 6 isoform X4

RNA

  1. XR_004933622.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D413.1 GenPept UniProtKB/Swiss-Prot:Q9D413

Gene LinkOut

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