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Stx18 syntaxin 18 [ Mus musculus (house mouse) ]

Gene ID: 71116, updated on 5-Mar-2024

Summary

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Official Symbol
Stx18provided by MGI
Official Full Name
syntaxin 18provided by MGI
Primary source
MGI:MGI:1918366
See related
Ensembl:ENSMUSG00000029125 AllianceGenome:MGI:1918366
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1810035L21Rik; 4933425D03Rik
Summary
Enables protein domain specific binding activity. Predicted to be involved in several processes, including endoplasmic reticulum membrane organization; positive regulation of ER to Golgi vesicle-mediated transport; and regulation of organelle organization. Predicted to act upstream of or within protein transport and vesicle-mediated transport. Predicted to be located in Golgi apparatus and membrane. Predicted to be integral component of membrane. Predicted to be part of SNARE complex. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and limb. Orthologous to human STX18 (syntaxin 18). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 18.0), CNS E18 (RPKM 17.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 B3; 5 20.21 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (38194073..38295114)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (38036729..38137770)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12911 Neighboring gene STARR-seq mESC enhancer starr_12912 Neighboring gene predicted gene, 54328 Neighboring gene VISTA enhancer mm429 Neighboring gene predicted gene, 40289 Neighboring gene STARR-positive B cell enhancer mm9_chr5:38414144-38414444 Neighboring gene VISTA enhancer mm1165 Neighboring gene neuron specific gene family member 1 Neighboring gene STARR-positive B cell enhancer mm9_chr5:38602912-38603212 Neighboring gene zinc finger and BTB domain containing 49 Neighboring gene Ly1 antibody reactive clone

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Involvement of syntaxin 18, an endoplasmic reticulum (ER)-localized SNARE protein, in ER-mediated phagocytosis. Hatsuzawa K, et al. Mol Biol Cell, 2006 Sep. PMID 16790498, Free PMC Article
  2. Bovine papillomavirus type 1 infection is mediated by SNARE syntaxin 18. Laniosz V, et al. J Virol, 2007 Jul. PMID 17475643, Free PMC Article
  3. Sec22b is a negative regulator of phagocytosis in macrophages. Hatsuzawa K, et al. Mol Biol Cell, 2009 Oct. PMID 19710423, Free PMC Article
  4. Physical mapping of the mouse tilted locus identifies an association between human deafness loci DFNA6/14 and vestibular system development. Hurle B, et al. Genomics, 2001 Oct. PMID 11597144
  5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SNAP receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in endoplasmic reticulum membrane organization ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of ER to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of organelle assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of Golgi organization ISO
Inferred from Sequence Orthology
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
syntaxin-18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289535.1 → NP_001276464.1  syntaxin-18 isoform 2

    See identical proteins and their annotated locations for NP_001276464.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC115931, AK007700, AK169273, BY037320
    Consensus CDS
    CCDS71583.1
    UniProtKB/Swiss-Prot
    Q8VDS8
    Related
    ENSMUSP00000031008.7, ENSMUST00000031008.13
    Conserved Domains (2) summary
    cd15850
    Location:245 → 303
    SNARE_syntaxin18; SNARE motif, subgroup Qa
    pfam10496
    Location:4 → 96
    Syntaxin-18_N; SNARE-complex protein Syntaxin-18 N-terminus

  2. NM_001289536.1 → NP_001276465.1  syntaxin-18 isoform 3

    See identical proteins and their annotated locations for NP_001276465.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC115931, AC121811
    Consensus CDS
    CCDS80270.1
    UniProtKB/Swiss-Prot
    Q8VDS8
    Related
    ENSMUSP00000038205.9, ENSMUST00000042146.15
    Conserved Domains (2) summary
    cd15850
    Location:219 → 277
    SNARE_syntaxin18; SNARE motif, subgroup Qa
    pfam10496
    Location:4 → 96
    Syntaxin-18_N; SNARE-complex protein Syntaxin-18 N-terminus

  3. NM_001359398.1 → NP_001346327.1  syntaxin-18 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (4) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC115931, AC121811
    UniProtKB/TrEMBL
    D3YY98
    Related
    ENSMUSP00000118218.2, ENSMUST00000154929.5
    Conserved Domains (1) summary
    cd15850
    Location:191 → 249
    SNARE_syntaxin18; SNARE motif, subgroup Qa

  4. NM_026959.3 → NP_081235.2  syntaxin-18 isoform 1

    See identical proteins and their annotated locations for NP_081235.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC115931, AK169273, BY037320
    Consensus CDS
    CCDS19250.1
    UniProtKB/Swiss-Prot
    Q3TDJ0, Q8VDS8, Q9D8T6
    Related
    ENSMUSP00000109761.3, ENSMUST00000114126.9
    Conserved Domains (2) summary
    cd15850
    Location:245 → 303
    SNARE_syntaxin18; SNARE motif, subgroup Qa
    pfam10496
    Location:4 → 96
    Syntaxin-18_N; SNARE-complex protein Syntaxin-18 N-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    38194073..38295114
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254807.1 → XP_030110667.1  syntaxin-18 isoform X1

    UniProtKB/TrEMBL
    D3YY98
    Conserved Domains (1) summary
    cd15850
    Location:191 → 249
    SNARE_syntaxin18; SNARE motif, subgroup Qa

  2. XM_006504112.5 → XP_006504175.1  syntaxin-18 isoform X2

    UniProtKB/TrEMBL
    D3YY98
    Conserved Domains (1) summary
    cd15850
    Location:164 → 222
    SNARE_syntaxin18; SNARE motif, subgroup Qa
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VDS8.2 GenPept UniProtKB/Swiss-Prot:Q8VDS8

Gene LinkOut

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