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Cdkl1 cyclin dependent kinase like 1 [ Mus musculus (house mouse) ]

Gene ID: 71091, updated on 11-Apr-2024

Summary

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Official Symbol
Cdkl1provided by MGI
Official Full Name
cyclin dependent kinase like 1provided by MGI
Primary source
MGI:MGI:1918341
See related
Ensembl:ENSMUSG00000020990 AllianceGenome:MGI:1918341
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4933411O17Rik
Summary
Predicted to enable cyclin-dependent protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation. Predicted to act upstream of or within phosphorylation. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in renal calyx and rest of cerebellum mantle layer. Orthologous to human CDKL1 (cyclin dependent kinase like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 23.9), ovary adult (RPKM 3.4) and 7 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 C2; 12 28.94 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (69791944..69838057, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (69745167..69791196, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene L-2-hydroxyglutarate dehydrogenase Neighboring gene STARR-seq mESC enhancer starr_32374 Neighboring gene STARR-positive B cell enhancer ABC_E2387 Neighboring gene STARR-positive B cell enhancer mm9_chr12:70834549-70834850 Neighboring gene distal membrane arm assembly component 2 like Neighboring gene VISTA enhancer mm122 Neighboring gene microRNA 681 Neighboring gene RIKEN cDNA 4930512B01 gene Neighboring gene mitogen-activated protein kinase kinase kinase kinase 5 Neighboring gene STARR-seq mESC enhancer starr_32378 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene RIKEN cDNA 4931403G20 gene Neighboring gene STARR-positive B cell enhancer ABC_E8487

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. High-throughput mapping of a dynamic signaling network in mammalian cells. Barrios-Rodiles M, et al. Science, 2005 Mar 11. PMID 15761153
  2. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC144706, MGC144707

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cyclin-dependent kinase-like 1
Names
cyclin dependent kinase like 1 (CDC2 related kinase)
NP_899117.1
XP_011242478.1
XP_011242479.1
XP_017170692.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_183294.2 → NP_899117.1  cyclin-dependent kinase-like 1

    See identical proteins and their annotated locations for NP_899117.1

    Status: PROVISIONAL

    Source sequence(s)
    AK016781
    Consensus CDS
    CCDS25955.1
    UniProtKB/Swiss-Prot
    Q8CEQ0
    UniProtKB/TrEMBL
    Q14BG3
    Related
    ENSMUSP00000021377.5, ENSMUST00000021377.5
    Conserved Domains (1) summary
    cd07847
    Location:2 → 287
    STKc_CDKL1_4; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 1 and 4

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    69791944..69838057 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011244176.4 → XP_011242478.1  cyclin-dependent kinase-like 1 isoform X2

    See identical proteins and their annotated locations for XP_011242478.1

    Conserved Domains (1) summary
    cl21453
    Location:44 → 212
    PKc_like; Protein Kinases, catalytic domain

  2. XM_017315203.3 → XP_017170692.1  cyclin-dependent kinase-like 1 isoform X1

    UniProtKB/Swiss-Prot
    Q8CEQ0
    UniProtKB/TrEMBL
    Q14BG3
    Conserved Domains (1) summary
    cd07847
    Location:2 → 287
    STKc_CDKL1_4; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 1 and 4

  3. XM_011244177.4 → XP_011242479.1  cyclin-dependent kinase-like 1 isoform X2

    See identical proteins and their annotated locations for XP_011242479.1

    Conserved Domains (1) summary
    cl21453
    Location:44 → 212
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CEQ0.1 GenPept UniProtKB/Swiss-Prot:Q8CEQ0

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