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Septin12 septin 12 [ Mus musculus (house mouse) ]

Gene ID: 71089, updated on 21-Apr-2024

Summary

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Official Symbol
Septin12provided by MGI
Official Full Name
septin 12provided by MGI
Primary source
MGI:MGI:1918339
See related
Ensembl:ENSMUSG00000022542 AllianceGenome:MGI:1918339
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sept12; 1700028G04Rik; 4933413B09Rik
Summary
Predicted to enable several functions, including GTP binding activity; GTPase activity; and protein homodimerization activity. Involved in flagellated sperm motility. Predicted to be located in several cellular components, including midbody; perinuclear region of cytoplasm; and sperm annulus. Predicted to be part of septin complex. Predicted to be active in cell division site; microtubule cytoskeleton; and septin ring. Human ortholog(s) of this gene implicated in spermatogenic failure 10. Orthologous to human SEPTIN12 (septin 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 124.0) See more
Orthologs
human all
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Genomic context

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Location:
16 A1; 16 2.49 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (4804722..4815716, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (4986858..4997852, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and sterile alpha motif domain containing 3 Neighboring gene predicted gene, 36681 Neighboring gene dynein axonemal assembly factor 8 Neighboring gene STARR-positive B cell enhancer ABC_E7426 Neighboring gene small integral membrane protein 22 Neighboring gene rogdi homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Homozygous Loss of Septin12, but not its Haploinsufficiency, Leads to Male Infertility and Fertilization Failure. Chen H, et al. Front Cell Dev Biol, 2022. PMID 35547809, Free PMC Article
  2. The SEPT12 complex is required for the establishment of a functional sperm head-tail junction. Shen YR, et al. Mol Hum Reprod, 2020 Jun 1. PMID 32392324
  3. SEPT12 phosphorylation results in loss of the septin ring/sperm annulus, defective sperm motility and poor male fertility. Shen YR, et al. PLoS Genet, 2017 Mar. PMID 28346465, Free PMC Article
  4. SEPT12 deficiency causes sperm nucleus damage and developmental arrest of preimplantation embryos. Lin YH, et al. Fertil Steril, 2011 Jan. PMID 20801438
  5. Proper phosphorylation of septin 12 regulates septin 4 and soluble adenylyl cyclase expression to induce sperm capacitation. Wang HY, et al. J Cell Physiol, 2023 Mar. PMID 36715674

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Proper phosphorylation of septin 12 regulates septin 4 and soluble adenylyl cyclase expression to induce sperm capacitation.
    Title: Proper phosphorylation of septin 12 regulates septin 4 and soluble adenylyl cyclase expression to induce sperm capacitation.
  2. We concluded that CDC42 negatively regulates SEPT12 polymerization and is involved in terminal structure formation of sperm heads.
    Title: CDC42 Negatively Regulates Testis-Specific SEPT12 Polymerization.
  3. Data suggest that SEPT12 phosphorylation inhibits septin ring assembly during annulus biogenesis.
    Title: SEPT12 phosphorylation results in loss of the septin ring/sperm annulus, defective sperm motility and poor male fertility.
  4. In mice sperm with mutated SEPT12, NDC1 dispersed around the manchette region of the sperm head and annulus, compared with concentrating at the sperm neck of wild-type sperm.
    Title: SEPT12-NDC1 Complexes Are Required for Mammalian Spermiogenesis.
  5. results demonstrate the molecular architecture of SEPT12 filaments at the sperm annulus, their mechanical support of sperm motility, and their correlation with male infertility.
    Title: SEPT12 orchestrates the formation of mammalian sperm annulus by organizing core octameric complexes with other SEPT proteins.
  6. Oocytes fertilized with spermatozoa obtained from Septin 12+/- chimeric mice failed to develop beyond the morula stage after IVF and intracytoplasmic sperm injection because of significant DNA defects in the spermatozoa
    Title: SEPT12 deficiency causes sperm nucleus damage and developmental arrest of preimplantation embryos.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Clone Names

  • MGC144518

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cytoskeleton-dependent cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell division site IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of septin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of septin complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in septin ring IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sperm annulus ISO
Inferred from Sequence Orthology
more info
  
located_in spindle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
septin-12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001373945.1 → NP_001360874.1  septin-12 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC163723
    Consensus CDS
    CCDS88872.1
    UniProtKB/TrEMBL
    A0A2R8VJU7
    Related
    ENSMUSP00000154901.2, ENSMUST00000230362.2
    Conserved Domains (1) summary
    cd01850
    Location:45 → 315
    CDC_Septin; CDC/Septin GTPase family

  2. NM_027669.3 → NP_081945.1  septin-12 isoform 1

    See identical proteins and their annotated locations for NP_081945.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AK077091
    Consensus CDS
    CCDS27929.1
    UniProtKB/TrEMBL
    Q9D451
    Related
    ENSMUSP00000131062.3, ENSMUST00000170323.3
    Conserved Domains (1) summary
    cd01850
    Location:45 → 272
    CDC_Septin; CDC/Septin GTPase family

  3. NM_029374.1 → NP_083650.1  septin-12 isoform 2

    See identical proteins and their annotated locations for NP_083650.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses two alternate splice sites in the 3' coding region, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK006458, AK077091
    Consensus CDS
    CCDS88871.1
    UniProtKB/TrEMBL
    Q9D9U8
    Related
    ENSMUSP00000155459.2, ENSMUST00000229321.2
    Conserved Domains (1) summary
    cd01850
    Location:45 → 272
    CDC_Septin; CDC/Septin GTPase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    4804722..4815716 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522580.1 → XP_006522643.1  septin-12 isoform X3

    Conserved Domains (1) summary
    cd01850
    Location:45 → 272
    CDC_Septin; CDC/Septin GTPase family

  2. XM_006522577.2 → XP_006522640.1  septin-12 isoform X1

    Conserved Domains (1) summary
    cd01850
    Location:45 → 320
    CDC_Septin; CDC/Septin GTPase family

  3. XM_006522579.3 → XP_006522642.1  septin-12 isoform X2

    Conserved Domains (1) summary
    cd01850
    Location:2 → 258
    CDC_Septin; CDC/Septin GTPase family
Nucleotide Protein Strain
Heading Accession and Version

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