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Zfp597 zinc finger protein 597 [ Mus musculus (house mouse) ]

Gene ID: 71063, updated on 5-Mar-2024

Summary

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Official Symbol
Zfp597provided by MGI
Official Full Name
zinc finger protein 597provided by MGI
Primary source
MGI:MGI:1918313
See related
Ensembl:ENSMUSG00000039789 AllianceGenome:MGI:1918313
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4933407K12Rik
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Is expressed in bladder; female associated reproductive structure; ovary; ureter; and urethra of female. Orthologous to human ZNF597 (zinc finger protein 597). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 3.2), CNS E18 (RPKM 3.2) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp597 in Genome Data Viewer
Location:
16 A1; 16 2.27 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (3679408..3702241, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (3861544..3884377, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_39909 Neighboring gene predicted gene, 41409 Neighboring gene STARR-seq mESC enhancer starr_39910 Neighboring gene STARR-positive B cell enhancer ABC_E5522 Neighboring gene olfactory receptor family 2 subfamily C member 1 Neighboring gene zinc finger protein 174 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:3872304-3872526 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:3872697-3872880 Neighboring gene STARR-positive B cell enhancer mm9_chr16:3884448-3884748 Neighboring gene N(alpha)-acetyltransferase 60, NatF catalytic subunit Neighboring gene RIKEN cDNA 1700037C18 gene Neighboring gene predicted gene, 41410 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:3908535-3908837 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:3909019-3909128 Neighboring gene clusterin associated protein 1 Neighboring gene prothymosin alpha-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular characterization and gene disruption of a novel zinc-finger protein, HIT-4, expressed in rodent brain. Tanabe Y, et al. J Neurochem, 2010 Feb. PMID 19968752
  2. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results reveal novel biological and pathological roles of HIT-4 in brain development and/or maintenance in mice.
    Title: Molecular characterization and gene disruption of a novel zinc-finger protein, HIT-4, expressed in rodent brain.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC118564

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 597

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033159.2 → NP_001028331.2  zinc finger protein 597

    Status: VALIDATED

    Source sequence(s)
    AAHY01125318, AK016727
    Consensus CDS
    CCDS27911.1
    UniProtKB/TrEMBL
    E9Q6S0
    Related
    ENSMUSP00000088009.5, ENSMUST00000090522.5
    Conserved Domains (5) summary
    COG5048
    Location:183 → 242
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:157 → 177
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:183 → 205
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:16 → 53
    KRAB; KRAB box
    pfam13465
    Location:197 → 222
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    3679408..3702241 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522576.5 → XP_006522639.1  zinc finger protein 597 isoform X1

    Conserved Domains (3) summary
    COG5189
    Location:77 → 160
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:54 → 74
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:94 → 119
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version

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