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D7Ertd443e DNA segment, Chr 7, ERATO Doi 443, expressed [ Mus musculus (house mouse) ]

Gene ID: 71007, updated on 5-Mar-2024

Summary

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Official Symbol
D7Ertd443eprovided by MGI
Official Full Name
DNA segment, Chr 7, ERATO Doi 443, expressedprovided by MGI
Primary source
MGI:MGI:1196431
See related
Ensembl:ENSMUSG00000030994 AllianceGenome:MGI:1196431
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FATS; Gm497; 4933400E14Rik
Summary
Enables histone deacetylase binding activity and ubiquitin protein ligase activity. Involved in several processes, including mitotic G2 DNA damage checkpoint signaling; protein stabilization; and response to ionizing radiation. Predicted to be located in several cellular components, including actin cytoskeleton; nucleoplasm; and plasma membrane. Predicted to be active in centriole; centrosome; and cytosol. Orthologous to human C10orf90 (chromosome 10 open reading frame 90). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 9.5) and cerebellum adult (RPKM 0.7) See more
Orthologs
human all
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Genomic context

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Location:
7 F3; 7 78.4 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (133867509..134121888, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (134265780..134520159, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_20337 Neighboring gene ADAM metallopeptidase domain 12 Neighboring gene STARR-seq mESC enhancer starr_20338 Neighboring gene predicted gene, 51500 Neighboring gene predicted gene, 39103 Neighboring gene STARR-seq mESC enhancer starr_20339 Neighboring gene STARR-seq mESC enhancer starr_20340 Neighboring gene STARR-seq mESC enhancer starr_20341 Neighboring gene STARR-seq mESC enhancer starr_20343 Neighboring gene STARR-seq mESC enhancer starr_20344 Neighboring gene predicted gene, 35970 Neighboring gene STARR-seq mESC enhancer starr_20345 Neighboring gene STARR-seq mESC enhancer starr_20346 Neighboring gene methionine aminopeptidase 2 pseudogene Neighboring gene dedicator of cytokinesis 1 Neighboring gene STARR-seq mESC enhancer starr_20355 Neighboring gene STARR-seq mESC enhancer starr_20356 Neighboring gene inhibitory synaptic factor 2A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss of fragile site-associated tumor suppressor promotes antitumor immunity via macrophage polarization. Zhang L, et al. Nat Commun, 2021 Jul 14. PMID 34262035, Free PMC Article
  2. FATS is a transcriptional target of p53 and associated with antitumor activity. Zhang X, et al. Mol Cancer, 2010 Sep 16. PMID 20843368, Free PMC Article
  3. An HDAC1-binding domain within FATS bridges p21 turnover to radiation-induced tumorigenesis. Li Z, et al. Oncogene, 2010 May 6. PMID 20154723
  4. FATS is an E2-independent ubiquitin ligase that stabilizes p53 and promotes its activation in response to DNA damage. Yan S, et al. Oncogene, 2014 Nov 20. PMID 24240685
  5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables histone deacetylase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitotic G2 DNA damage checkpoint signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of cell growth IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein polyubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein stabilization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of centriole replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to UV IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to ionizing radiation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
(E2-independent) E3 ubiquitin-conjugating enzyme FATS
Names
E2/E3 hybrid ubiquitin-protein ligase FATS
centrosomal protein C10orf90 homolog
fragile-site associated tumor suppressor homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081331.2 → NP_001074800.1  (E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform 2

    See identical proteins and their annotated locations for NP_001074800.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC124369, AC126676
    Consensus CDS
    CCDS57590.1
    UniProtKB/Swiss-Prot
    D2J0Y4
    UniProtKB/TrEMBL
    Q3ULM5
    Related
    ENSMUSP00000091539.4, ENSMUST00000094002.10
    Conserved Domains (2) summary
    pfam15309
    Location:514 → 641
    ALMS_motif; ALMS motif
    pfam17730
    Location:5 → 509
    Centro_C10orf90; Centrosomal C10orf90

  2. NM_001199941.1 → NP_001186870.1  (E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    GQ499374
    Consensus CDS
    CCDS57591.1
    UniProtKB/TrEMBL
    G3UZF7, Q3ULM5
    Related
    ENSMUSP00000134479.2, ENSMUST00000172947.8
    Conserved Domains (1) summary
    pfam15309
    Location:561 → 689
    ALMS_motif; ALMS motif

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    133867509..134121888 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241903.3 → XP_011240205.1  (E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform X3

    UniProtKB/TrEMBL
    Q3ULM5
    Conserved Domains (2) summary
    pfam15309
    Location:530 → 657
    ALMS_motif; ALMS motif
    pfam17730
    Location:21 → 525
    Centro_C10orf90; Centrosomal C10orf90

  2. XM_011241905.4 → XP_011240207.1  (E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform X4

    See identical proteins and their annotated locations for XP_011240207.1

    UniProtKB/Swiss-Prot
    D2J0Y4
    UniProtKB/TrEMBL
    Q3ULM5
    Conserved Domains (2) summary
    pfam15309
    Location:514 → 641
    ALMS_motif; ALMS motif
    pfam17730
    Location:5 → 509
    Centro_C10orf90; Centrosomal C10orf90

  3. XM_011241901.2 → XP_011240203.1  (E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform X1

    See identical proteins and their annotated locations for XP_011240203.1

    UniProtKB/TrEMBL
    Q3ULM5
    Conserved Domains (2) summary
    pfam15309
    Location:591 → 718
    ALMS_motif; ALMS motif
    pfam17730
    Location:82 → 586
    Centro_C10orf90; Centrosomal C10orf90

  4. XM_011241906.3 → XP_011240208.1  (E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform X5

    UniProtKB/TrEMBL
    Q3ULM5
    Conserved Domains (2) summary
    pfam15309
    Location:496 → 623
    ALMS_motif; ALMS motif
    pfam17730
    Location:82 → 491
    Centro_C10orf90; Centrosomal C10orf90

  5. XM_011241902.4 → XP_011240204.1  (E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform X2

    UniProtKB/TrEMBL
    Q3ULM5
    Conserved Domains (2) summary
    pfam15309
    Location:545 → 672
    ALMS_motif; ALMS motif
    pfam17730
    Location:36 → 540
    Centro_C10orf90; Centrosomal C10orf90

  6. XM_011241904.4 → XP_011240206.1  (E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform X4

    See identical proteins and their annotated locations for XP_011240206.1

    UniProtKB/Swiss-Prot
    D2J0Y4
    UniProtKB/TrEMBL
    Q3ULM5
    Conserved Domains (2) summary
    pfam15309
    Location:514 → 641
    ALMS_motif; ALMS motif
    pfam17730
    Location:5 → 509
    Centro_C10orf90; Centrosomal C10orf90

  7. XM_011241907.4 → XP_011240209.1  (E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform X6

    See identical proteins and their annotated locations for XP_011240209.1

    UniProtKB/TrEMBL
    F7AZE7, Q9D4E0
    Related
    ENSMUSP00000101735.3, ENSMUST00000106129.9
    Conserved Domains (2) summary
    pfam15309
    Location:155 → 282
    ALMS_motif; ALMS motif
    pfam17730
    Location:3 → 150
    Centro_C10orf90; Centrosomal C10orf90
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D2J0Y4.1 GenPept UniProtKB/Swiss-Prot:D2J0Y4

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