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Prss41 serine protease 41 [ Mus musculus (house mouse) ]

Gene ID: 71003, updated on 8-Feb-2024

Summary

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Official Symbol
Prss41provided by MGI
Official Full Name
serine protease 41provided by MGI
Primary source
MGI:MGI:1918253
See related
Ensembl:ENSMUSG00000024114 AllianceGenome:MGI:1918253
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tessp1; Tessp-1; 4931440B09Rik
Summary
Predicted to enable sodium channel regulator activity. Predicted to act upstream of or within proteolysis. Located in plasma membrane. Is expressed in eye; heart; lung; male reproductive gland or organ; and smooth muscle tissue. Orthologous to human PRSS41 (serine protease 41). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 3.8), colon adult (RPKM 1.0) and 10 other tissues See more
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Genomic context

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Location:
17 A3.3; 17 12.09 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24055759..24063190, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (23836785..23844219, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene serine/arginine repetitive matrix 2 Neighboring gene STARR-positive B cell enhancer ABC_E11792 Neighboring gene elongin B Neighboring gene serine protease 33 Neighboring gene serine protease 32 Neighboring gene serine protease 21

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A testis-specific serine protease, Prss41/Tessp-1, is necessary for the progression of meiosis during murine in vitro spermatogenesis. Yoneda R, et al. Biochem Biophys Res Commun, 2013 Nov 8. PMID 24129193
  2. TESSP-1: a novel serine protease gene expressed in the spermatogonia and spermatocytes of adult mouse testes. Takano N, et al. Mol Reprod Dev, 2005 Jan. PMID 15515062
  3. Two distinct localization patterns of testis-specific serine protease 1 (TESSP1) in the seminiferous tubules of the mouse testis. Takano N, et al. Zoolog Sci, 2009 Apr. PMID 19798924
  4. Identification of a subgroup of glycosylphosphatidylinositol-anchored tryptases. Wong GW, et al. Biochem Biophys Res Commun, 2005 Oct 21. PMID 16143303
  5. Mouse chromosome 17A3.3 contains 13 genes that encode functional tryptic-like serine proteases with distinct tissue and cell expression patterns. Wong GW, et al. J Biol Chem, 2004 Jan 23. PMID 14583634

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the Prss/Tessp proteases are important for the progression of meiosis at each stage.
    Title: A testis-specific serine protease, Prss41/Tessp-1, is necessary for the progression of meiosis during murine in vitro spermatogenesis.
  2. The results of this study suggest that TESSP1 is predominantly localized in the plasma membrane of spermatogonia and Sertoli cells in the basal compartment.
    Title: Two distinct localization patterns of testis-specific serine protease 1 (TESSP1) in the seminiferous tubules of the mouse testis.
  3. A novel type of serine protease, designated testis-specific serine protease 1 (TESSP-1), from the adult mouse testis was cloned.
    Title: TESSP-1: a novel serine protease gene expressed in the spermatogonia and spermatocytes of adult mouse testes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in intracellular organelle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine protease 41
Names
protease, serine 41
testis serine protease 1
testis-specific serine protease 1
NP_001405693.1
NP_001405694.1
NP_081920.1
XP_036016678.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418764.1 → NP_001405693.1  serine protease 41 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC122821

  2. NM_001418765.1 → NP_001405694.1  serine protease 41 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC122821
    Related
    ENSMUSP00000122453.2, ENSMUST00000151797.3

  3. NM_027644.2 → NP_081920.1  serine protease 41 isoform 1 precursor

    See identical proteins and their annotated locations for NP_081920.1

    Status: VALIDATED

    Source sequence(s)
    AC122821
    Consensus CDS
    CCDS28466.1
    UniProtKB/Swiss-Prot
    Q8BX01, Q920S2
    UniProtKB/TrEMBL
    B9EK99
    Related
    ENSMUSP00000024926.8, ENSMUST00000024926.14
    Conserved Domains (2) summary
    smart00020
    Location:52 → 289
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:53 → 290
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    24055759..24063190 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160785.1 → XP_036016678.1  serine protease 41 isoform X1

    UniProtKB/TrEMBL
    B9EK99
    Conserved Domains (1) summary
    cd00190
    Location:84 → 321
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q920S2.1 GenPept UniProtKB/Swiss-Prot:Q920S2

Gene LinkOut

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