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Naa40 N(alpha)-acetyltransferase 40, NatD catalytic subunit [ Mus musculus (house mouse) ]

Gene ID: 70999, updated on 21-Apr-2024

Summary

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Official Symbol
Naa40provided by MGI
Official Full Name
N(alpha)-acetyltransferase 40, NatD catalytic subunitprovided by MGI
Primary source
MGI:MGI:1918249
See related
Ensembl:ENSMUSG00000024764 AllianceGenome:MGI:1918249
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NatD; Nat11; 4931433E08Rik
Summary
Predicted to enable H2A histone acetyltransferase activity; H4 histone acetyltransferase activity; and peptide-serine-N-acetyltransferase activity. Acts upstream of or within lipid metabolic process. Predicted to be located in centriolar satellite; cytosol; and nucleoplasm. Predicted to be active in nucleus. Orthologous to human NAA40 (N-alpha-acetyltransferase 40, NatD catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 26.2), whole brain E14.5 (RPKM 19.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 A; 19 5.29 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (7203033..7218587, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (7225668..7241222, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene OTU domain, ubiquitin aldehyde binding 1 Neighboring gene STARR-positive B cell enhancer ABC_E8735 Neighboring gene cytochrome c oxidase subunit 8A Neighboring gene STARR-positive B cell enhancer ABC_E11671 Neighboring gene STARR-positive B cell enhancer ABC_E8736 Neighboring gene predicted gene, 22113 Neighboring gene STARR-seq mESC enhancer starr_45459 Neighboring gene REST corepressor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Histone acetyltransferase NAA40 modulates acetyl-CoA levels and lipid synthesis. Charidemou E, et al. BMC Biol, 2022 Jan 20. PMID 35057804, Free PMC Article
  2. Liver Patt1 deficiency protects male mice from age-associated but not high-fat diet-induced hepatic steatosis. Liu Y, et al. J Lipid Res, 2012 Mar. PMID 22231784, Free PMC Article
  3. Interaction of Sox2 with RNA binding proteins in mouse embryonic stem cells. Samudyata, et al. Exp Cell Res, 2019 Aug 1. PMID 31077711, Free PMC Article
  4. The central role of EED in the orchestration of polycomb group complexes. Cao Q, et al. Nat Commun, 2014. PMID 24457600, Free PMC Article
  5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Histone acetyltransferase NAA40 modulates acetyl-CoA levels and lipid synthesis.
    Title: Histone acetyltransferase NAA40 modulates acetyl-CoA levels and lipid synthesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
  
enables histone H2A acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H2A acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H4 acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H4 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables peptide-serine-alpha-N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide-serine-alpha-N-acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
N-alpha-acetyltransferase 40
Names
N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog
N-acetyltransferase 11
N-alpha-acetyltransferase D
Nalpha acetyltransferase 40
natD catalytic subunit
protein acetyltransferase 1
NP_081919.1
XP_006527399.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027643.1 → NP_081919.1  N-alpha-acetyltransferase 40

    See identical proteins and their annotated locations for NP_081919.1

    Status: VALIDATED

    Source sequence(s)
    AK033510, AK033896, BB112808, BY107005
    Consensus CDS
    CCDS50377.1
    UniProtKB/Swiss-Prot
    Q3V3R7, Q6PE89, Q8VE10, Q9D4I5
    Related
    ENSMUSP00000025675.10, ENSMUST00000025675.11
    Conserved Domains (1) summary
    pfam00583
    Location:80 → 188
    Acetyltransf_1; Acetyltransferase (GNAT) family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    7203033..7218587 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527336.5 → XP_006527399.1  N-alpha-acetyltransferase 40 isoform X1

    Conserved Domains (1) summary
    cl17182
    Location:94 → 135
    NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VE10.1 GenPept UniProtKB/Swiss-Prot:Q8VE10

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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