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Nol8 nucleolar protein 8 [ Mus musculus (house mouse) ]

Gene ID: 70930, updated on 21-Apr-2024

Summary

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Official Symbol
Nol8provided by MGI
Official Full Name
nucleolar protein 8provided by MGI
Primary source
MGI:MGI:1918180
See related
Ensembl:ENSMUSG00000021392 AllianceGenome:MGI:1918180
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4921532D18Rik; 5730412B09Rik
Summary
Predicted to enable RNA binding activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in chromosome. Predicted to be active in nucleolus. Is expressed in central nervous system and sensory organ. Orthologous to human NOL8 (nucleolar protein 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 7.6), CNS E11.5 (RPKM 5.9) and 17 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 A5; 13 25.36 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (49806554..49832492)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (49653078..49679016)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene centromere protein P Neighboring gene STARR-seq mESC enhancer starr_34480 Neighboring gene osteomodulin Neighboring gene osteoglycin Neighboring gene STARR-positive B cell enhancer ABC_E1463 Neighboring gene STARR-positive B cell enhancer ABC_E8527 Neighboring gene predicted gene, 53786 Neighboring gene predicted gene, 25394 Neighboring gene isoleucyl-tRNA synthetase 1 Neighboring gene predicted gene, 23482

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes. Bulfone A, et al. J Neurosci, 2005 Aug 17. PMID 16107646, Free PMC Article
  2. The sperm-associated antigen 6 interactome and its role in spermatogenesis. Liu Y, et al. Reproduction, 2019 Aug. PMID 31146259, Free PMC Article
  3. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
  4. miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. Tarantino C, et al. FASEB J, 2010 Sep. PMID 20439489
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in protein localization to nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to nucleolus ISO
Inferred from Sequence Orthology
more info
  
involved_in rRNA processing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in chromosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nucleolar protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271397.1 → NP_001258326.1  nucleolar protein 8

    See identical proteins and their annotated locations for NP_001258326.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the protein.
    Source sequence(s)
    AK014994, AK147172, BC125575
    Consensus CDS
    CCDS36658.1
    UniProtKB/TrEMBL
    E9QKD1
    Related
    ENSMUSP00000152536.2, ENSMUST00000222197.2
    Conserved Domains (1) summary
    cd12226
    Location:27 → 106
    RRM_NOL8; RNA recognition motif in nucleolar protein 8 (NOL8) and similar proteins

RNA

  1. NR_073167.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site at the 5' end, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK014994, AK147172, BC058699

  2. NR_073168.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site near the 5' end, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC160978, AK014994, AK147172

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    49806554..49832492
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516956.3 → XP_006517019.2  nucleolar protein 8 isoform X1

    See identical proteins and their annotated locations for XP_006517019.2

    UniProtKB/Swiss-Prot
    Q059P5, Q3UHX0, Q504M4, Q8CDJ7, Q9CUR0
    Related
    ENSMUSP00000152878.2, ENSMUST00000223467.2
    Conserved Domains (1) summary
    cd12226
    Location:9 → 88
    RRM_NOL8; RNA recognition motif in nucleolar protein 8 (NOL8) and similar proteins

  2. XM_006516958.5 → XP_006517021.1  nucleolar protein 8 isoform X2

    See identical proteins and their annotated locations for XP_006517021.1

    UniProtKB/TrEMBL
    E9QKD1
    Conserved Domains (1) summary
    cd12226
    Location:27 → 106
    RRM_NOL8; RNA recognition motif in nucleolar protein 8 (NOL8) and similar proteins

  3. XM_006516957.1 → XP_006517020.1  nucleolar protein 8 isoform X2

    See identical proteins and their annotated locations for XP_006517020.1

    UniProtKB/TrEMBL
    E9QKD1
    Related
    ENSMUSP00000021824.8, ENSMUST00000021824.8
    Conserved Domains (1) summary
    cd12226
    Location:27 → 106
    RRM_NOL8; RNA recognition motif in nucleolar protein 8 (NOL8) and similar proteins

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001081350.1: Suppressed sequence

    Description
    NM_001081350.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UHX0.2 GenPept UniProtKB/Swiss-Prot:Q3UHX0

Gene LinkOut

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