Cdkn2aip CDKN2A interacting protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cdkn2aipprovided by MGI
Official Full Name: CDKN2A interacting proteinprovided by MGI
Primary source: MGI:MGI:1918175
See related: Ensembl:ENSMUSG00000038069 AllianceGenome:MGI:1918175
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CARF; 4921511I16Rik
Summary: Predicted to enable p53 binding activity. Predicted to be involved in several processes, including cellular response to DNA damage stimulus; regulation of cell growth; and regulation of protein stability. Located in nucleus. Is expressed in brain. Orthologous to human CDKN2AIP (CDKN2A interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 14.7), CNS E11.5 (RPKM 5.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 B1.1; 8 26.88 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (48162379..48166966, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (47709344..47713931, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Oncogenic functions of CARF in hepatocellular carcinoma tumorigenesis is a result of activation of beta-catenin/TCF signaling.
Title: CARF activates beta-catenin/TCF signaling in the hepatocellular carcinoma.
CARF may act as a novel key regulator of the p53 pathway at multiple checkpoints
Title: CARF: an emerging regulator of p53 tumor suppressor and senescence pathway.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Cdkn2aip (e-PCR), detects polymorphism
- UniSTS:478982

AW208986 (e-PCR)
- UniSTS:179743

NoName (e-PCR)
- UniSTS:235888

BB466728 (e-PCR)
- UniSTS:208279

RH132170 (e-PCR)
- UniSTS:215453

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables p53 binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein stability	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in granular component	ISO Inferred from Sequence Orthology more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: CDKN2A-interacting protein

Names: collaborates/cooperates with ARF (alternate reading frame) protein; collaborator of ARF

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.