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Nsun7 NOL1/NOP2/Sun domain family, member 7 [ Mus musculus (house mouse) ]

Gene ID: 70918, updated on 9-May-2024

Summary

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Official Symbol
Nsun7provided by MGI
Official Full Name
NOL1/NOP2/Sun domain family, member 7provided by MGI
Primary source
MGI:MGI:1918168
See related
Ensembl:ENSMUSG00000029206 AllianceGenome:MGI:1918168
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4921525L17Rik
Summary
This gene encodes a member of the NOL1/NOP2/sun domain RNA methyltransferase family. Mice with a mutation in this gene exhibit male sterility due to impaired sperm motility. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Expression
Biased expression in testis adult (RPKM 9.7), frontal lobe adult (RPKM 1.4) and 6 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 C3.1; 5 34.34 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (66417181..66457544)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (66259838..66299927)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700126H18 gene Neighboring gene predicted gene 43772 Neighboring gene STARR-seq mESC enhancer starr_13286 Neighboring gene STARR-seq mESC enhancer starr_13287 Neighboring gene STARR-seq mESC enhancer starr_13288 Neighboring gene predicted gene 15794 Neighboring gene STARR-seq mESC enhancer starr_13289 Neighboring gene STARR-seq mESC enhancer starr_13290 Neighboring gene STARR-seq mESC enhancer starr_13291 Neighboring gene amyloid beta precursor protein binding family B member 2 Neighboring gene STARR-seq mESC enhancer starr_13293 Neighboring gene STARR-seq mESC enhancer starr_13294 Neighboring gene predicted gene, 52775 Neighboring gene ubiquitin carboxy-terminal hydrolase L1, opposite strand Neighboring gene ubiquitin carboxy-terminal hydrolase L1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sperm motility defects and infertility in male mice with a mutation in Nsun7, a member of the Sun domain-containing family of putative RNA methyltransferases. Harris T, et al. Biol Reprod, 2007 Aug. PMID 17442852
  2. Expression of NOL1/NOP2/sun domain (Nsun) RNA methyltransferase family genes in early mouse embryogenesis. Chi L, et al. Gene Expr Patterns, 2013 Dec. PMID 23816522
  3. High resolution mapping and positional cloning of ENU-induced mutations in the Rw region of mouse chromosome 5. Ching YH, et al. BMC Genet, 2010 Nov 30. PMID 21118569, Free PMC Article
  4. Random mutagenesis of proximal mouse chromosome 5 uncovers predominantly embryonic lethal mutations. Wilson L, et al. Genome Res, 2005 Aug. PMID 16024820, Free PMC Article
  5. Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. Sundberg JP, et al. PLoS One, 2017. PMID 28700664, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sun domain containing protein Nsun7 mutant sperm exhibited depressed progressive motility associated with a rigid flagellar midpiece (but not principal piece) segment
    Title: Sperm motility defects and infertility in male mice with a mutation in Nsun7, a member of the Sun domain-containing family of putative RNA methyltransferases.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Chemically induced (ENU) (1)  1 citation
  • Targeted (2) 

General gene information

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Homology

Clone Names

  • MGC141647, MGC141648

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sperm mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
putative methyltransferase NSUN7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302833.2 → NP_001289762.1  putative methyltransferase NSUN7 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC131752
    Consensus CDS
    CCDS80290.1
    UniProtKB/Swiss-Prot
    Q14AW5, Q8BS48, Q9D5S9
    UniProtKB/TrEMBL
    E9QL78, E9QPI2
    Related
    ENSMUSP00000031109.5, ENSMUST00000031109.7
    Conserved Domains (1) summary
    cl17173
    Location:346 → 460
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  2. NM_001302834.2 → NP_001289763.1  putative methyltransferase NSUN7 isoform 2

    See identical proteins and their annotated locations for NP_001289763.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region and differs in the 3' exon structure, resulting in a different 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC131752
    Consensus CDS
    CCDS80291.1
    UniProtKB/Swiss-Prot
    Q14AW5, Q8BS48, Q9D5S9
    Related
    ENSMUSP00000144498.2, ENSMUST00000202994.4
    Conserved Domains (1) summary
    cl17173
    Location:346 → 426
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  3. NM_001400914.1 → NP_001387843.1  putative methyltransferase NSUN7 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC131752

  4. NM_027602.3 → NP_081878.1  putative methyltransferase NSUN7 isoform 3

    See identical proteins and their annotated locations for NP_081878.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks the 5' terminal exon and uses an alternate splice site in the 3' terminal exon resulting in a frameshift, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC131752
    Consensus CDS
    CCDS19314.1
    UniProtKB/Swiss-Prot
    Q14AW5, Q8BS48, Q9D5S9
    UniProtKB/TrEMBL
    A0A0J9YV71
    Conserved Domains (1) summary
    COG0144
    Location:338 → 515
    RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    66417181..66457544
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017321098.2 → XP_017176587.1  putative methyltransferase NSUN7 isoform X4

  2. XM_011240769.4 → XP_011239071.1  putative methyltransferase NSUN7 isoform X2

    See identical proteins and their annotated locations for XP_011239071.1

    UniProtKB/Swiss-Prot
    Q14AW5, Q8BS48, Q9D5S9
    UniProtKB/TrEMBL
    A0A0J9YV71
    Related
    ENSMUSP00000144520.2, ENSMUST00000201100.4
    Conserved Domains (1) summary
    COG0144
    Location:338 → 515
    RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]

  3. XM_006504102.5 → XP_006504165.1  putative methyltransferase NSUN7 isoform X1

    See identical proteins and their annotated locations for XP_006504165.1

    UniProtKB/Swiss-Prot
    Q14AW5, Q8BS48, Q9D5S9
    Conserved Domains (1) summary
    COG0144
    Location:338 → 515
    RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]

  4. XM_030254806.2 → XP_030110666.1  putative methyltransferase NSUN7 isoform X3

    UniProtKB/Swiss-Prot
    Q14AW5, Q8BS48, Q9D5S9
    Conserved Domains (1) summary
    COG0144
    Location:203 → 380
    RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]

  5. XM_006504105.5 → XP_006504168.1  putative methyltransferase NSUN7 isoform X5

    See identical proteins and their annotated locations for XP_006504168.1

    Conserved Domains (1) summary
    COG0144
    Location:35 → 212
    RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]

  6. XM_006504106.5 → XP_006504169.1  putative methyltransferase NSUN7 isoform X5

    See identical proteins and their annotated locations for XP_006504169.1

    Conserved Domains (1) summary
    COG0144
    Location:35 → 212
    RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]

RNA

  1. XR_004942559.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14AW5.2 GenPept UniProtKB/Swiss-Prot:Q14AW5

Gene LinkOut

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