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Phyhipl phytanoyl-CoA hydroxylase interacting protein-like [ Mus musculus (house mouse) ]

Gene ID: 70911, updated on 5-Mar-2024

Summary

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Official Symbol
Phyhiplprovided by MGI
Official Full Name
phytanoyl-CoA hydroxylase interacting protein-likeprovided by MGI
Primary source
MGI:MGI:1918161
See related
Ensembl:ENSMUSG00000037747 AllianceGenome:MGI:1918161
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PHY2; 4921522K17Rik
Summary
Located in mitochondrion. Is expressed in several structures, including nervous system; neural retina; and olfactory epithelium. Orthologous to human PHYHIPL (phytanoyl-CoA 2-hydroxylase interacting protein like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 75.5), cerebellum adult (RPKM 31.7) and 6 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 B5.3; 10 36.69 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (70393516..70435121, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (70557686..70599291, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_27082 Neighboring gene putative 60S ribosomal protein L39-like 5 Neighboring gene STARR-seq mESC enhancer starr_27083 Neighboring gene family with sequence similarity 13, member C Neighboring gene 60S ribosomal protein L35 pseudogene Neighboring gene RIKEN cDNA D630013N20 gene Neighboring gene expressed sequence BB187676 Neighboring gene predicted gene, 51772

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Ser19Stop single nucleotide polymorphism (SNP) of human PHYHIPL affects the cerebellum in mice. Sugimoto H, et al. Mol Brain, 2021 Mar 12. PMID 33712038, Free PMC Article
  2. Proteomic Analysis of the Spinophilin Interactome in Rodent Striatum Following Psychostimulant Sensitization. Watkins DS, et al. Proteomes, 2018 Dec 17. PMID 30562941, Free PMC Article
  3. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
phytanoyl-CoA hydroxylase-interacting protein-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001162846.1 → NP_001156318.1  phytanoyl-CoA hydroxylase-interacting protein-like isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC122896, AK029522, AK032166
    Consensus CDS
    CCDS48593.1
    UniProtKB/TrEMBL
    F7D3N3
    Related
    ENSMUSP00000125179.2, ENSMUST00000162251.8
    Conserved Domains (1) summary
    cd00063
    Location:7 → 112
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  2. NM_178621.4 → NP_848736.2  phytanoyl-CoA hydroxylase-interacting protein-like isoform 1

    See identical proteins and their annotated locations for NP_848736.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC122896, AK029522, AK032166
    Consensus CDS
    CCDS23914.1
    UniProtKB/Swiss-Prot
    A4FVA0, Q8BGT8, Q8BZJ1, Q8C0X3, Q8CFU1, Q8R0C1
    Related
    ENSMUSP00000045807.4, ENSMUST00000046513.10
    Conserved Domains (1) summary
    cd00063
    Location:52 → 157
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    70393516..70435121 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514112.4 → XP_006514175.1  phytanoyl-CoA hydroxylase-interacting protein-like isoform X1

    Conserved Domains (1) summary
    cd00063
    Location:35 → 140
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BGT8.1 GenPept UniProtKB/Swiss-Prot:Q8BGT8

Gene LinkOut

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