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Ints10 integrator complex subunit 10 [ Mus musculus (house mouse) ]

Gene ID: 70885, updated on 21-Mar-2024

Summary

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Official Symbol
Ints10provided by MGI
Official Full Name
integrator complex subunit 10provided by MGI
Primary source
MGI:MGI:1918135
See related
Ensembl:ENSMUSG00000031864 AllianceGenome:MGI:1918135
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4921521J11Rik
Summary
Predicted to be involved in snRNA processing. Predicted to be located in nucleus. Predicted to be part of integrator complex. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and spinal cord. Orthologous to human INTS10 (integrator complex subunit 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 17.4), testis adult (RPKM 15.1) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 B3.3; 8 33.88 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (69245729..69282062)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (68793929..68829410)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_21705 Neighboring gene SH2 domain containing 4A Neighboring gene STARR-seq mESC enhancer starr_21706 Neighboring gene RIKEN cDNA 1700125H03 gene Neighboring gene upstream binding transcription factor, RNA polymerase I-like 1 pseudogene Neighboring gene chondroitin sulfate N-acetylgalactosaminyltransferase 1 Neighboring gene STARR-seq mESC enhancer starr_21708 Neighboring gene STARR-seq mESC enhancer starr_21710 Neighboring gene STARR-positive B cell enhancer mm9_chr8:71151041-71151341 Neighboring gene STARR-positive B cell enhancer ABC_E5009 Neighboring gene STARR-seq mESC enhancer starr_21711 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:71317593-71317892 Neighboring gene ribosomal protein 10 pseudogene Neighboring gene predicted gene, 51577 Neighboring gene lipoprotein lipase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Elf5-centered transcription factor hub controls trophoblast stem cell self-renewal and differentiation through stoichiometry-sensitive shifts in target gene networks. Latos PA, et al. Genes Dev, 2015 Dec 1. PMID 26584622, Free PMC Article
  2. Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells. Latos PA, et al. Nat Commun, 2015 Jul 24. PMID 26206133, Free PMC Article
  3. Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development. Combes AN, et al. Dev Dyn, 2009 May. PMID 19334288, Free PMC Article
  4. The sperm-associated antigen 6 interactome and its role in spermatogenesis. Liu Y, et al. Reproduction, 2019 Aug. PMID 31146259, Free PMC Article
  5. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in snRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in snRNA processing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of integrator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of integrator complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
integrator complex subunit 10
Names
int10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001293791.2 → NP_001280720.1  integrator complex subunit 10 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC123813
    Consensus CDS
    CCDS80885.1
    UniProtKB/TrEMBL
    E9Q360, E9Q361
    Related
    ENSMUSP00000105871.2, ENSMUST00000110242.8

  2. NM_001293792.2 → NP_001280721.1  integrator complex subunit 10 isoform 2

    See identical proteins and their annotated locations for NP_001280721.1

    Status: VALIDATED

    Source sequence(s)
    AC123813
    Consensus CDS
    CCDS80886.1
    UniProtKB/TrEMBL
    A0A0R4J0V1, E9Q361
    Related
    ENSMUSP00000069908.2, ENSMUST00000070713.8

  3. NM_001359129.2 → NP_001346058.1  integrator complex subunit 10 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC123813
    UniProtKB/TrEMBL
    E9Q361

  4. NM_027590.5 → NP_081866.1  integrator complex subunit 10 isoform 3

    See identical proteins and their annotated locations for NP_081866.1

    Status: VALIDATED

    Source sequence(s)
    AC123813
    Consensus CDS
    CCDS22342.1
    UniProtKB/Swiss-Prot
    Q8BYC2, Q8BZI9, Q8K2A7, Q9D5U1
    UniProtKB/TrEMBL
    E9Q361
    Related
    ENSMUSP00000034328.7, ENSMUST00000034328.13

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    69245729..69282062
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509741.4 → XP_006509804.1  integrator complex subunit 10 isoform X1

    UniProtKB/TrEMBL
    E9Q361

  2. XM_006509743.5 → XP_006509806.1  integrator complex subunit 10 isoform X2

    UniProtKB/TrEMBL
    E9Q361

  3. XM_006509747.5 → XP_006509810.1  integrator complex subunit 10 isoform X5

    UniProtKB/TrEMBL
    E9Q361

  4. XM_036154289.1 → XP_036010182.1  integrator complex subunit 10 isoform X4

    UniProtKB/TrEMBL
    E9Q361

  5. XM_006509744.5 → XP_006509807.1  integrator complex subunit 10 isoform X3

    UniProtKB/TrEMBL
    E9Q361

  6. XM_036154290.1 → XP_036010183.1  integrator complex subunit 10 isoform X6

    UniProtKB/TrEMBL
    E9Q361
    Related
    ENSMUSP00000105870.2, ENSMUST00000110241.8

  7. XM_011242326.3 → XP_011240628.1  integrator complex subunit 10 isoform X7

    UniProtKB/TrEMBL
    E9Q361

  8. XM_030243763.2 → XP_030099623.1  integrator complex subunit 10 isoform X9

  9. XM_030243764.2 → XP_030099624.1  integrator complex subunit 10 isoform X10

  10. XM_030243765.1 → XP_030099625.1  integrator complex subunit 10 isoform X11

  11. XM_036154291.1 → XP_036010184.1  integrator complex subunit 10 isoform X8

RNA

  1. XR_004934877.1 RNA Sequence

  2. XR_004934876.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K2A7.3 GenPept UniProtKB/Swiss-Prot:Q8K2A7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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