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Armc3 armadillo repeat containing 3 [ Mus musculus (house mouse) ]

Gene ID: 70882, updated on 11-Apr-2024

Summary

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Official Symbol
Armc3provided by MGI
Official Full Name
armadillo repeat containing 3provided by MGI
Primary source
MGI:MGI:1918132
See related
Ensembl:ENSMUSG00000037683 AllianceGenome:MGI:1918132
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4921513G22Rik
Summary
Is expressed in embryo. Orthologous to human ARMC3 (armadillo repeat containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 7.9) and lung adult (RPKM 0.2) See more
Orthologs
human all
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Genomic context

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Location:
2 A3; 2 13.2 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (19203676..19315054)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (19198865..19310243)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03816 Neighboring gene predicted gene, 33592 Neighboring gene STARR-seq mESC enhancer starr_03817 Neighboring gene DiGeorge syndrome critical region gene 14 pseudogene Neighboring gene STARR-seq mESC enhancer starr_03818 Neighboring gene STARR-positive B cell enhancer ABC_E5893 Neighboring gene RIKEN cDNA 4930447M23 gene Neighboring gene STARR-seq mESC enhancer starr_03820 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:19310470-19310705 Neighboring gene STARR-seq mESC enhancer starr_03823 Neighboring gene methionine sulfoxide reductase B2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of novel lung genes in bronchial epithelium by serial analysis of gene expression. Lonergan KM, et al. Am J Respir Cell Mol Biol, 2006 Dec. PMID 16809635
  2. Autophagic elimination of ribosomes during spermiogenesis provides energy for flagellar motility. Lei Y, et al. Dev Cell, 2021 Aug 23. PMID 34428398
  3. Next-generation sequencing identifies the Danforth's short tail mouse mutation as a retrotransposon insertion affecting Ptf1a expression. Vlangos CN, et al. PLoS Genet, 2013. PMID 23437000, Free PMC Article
  4. A retrotransposon insertion in the 5' regulatory domain of Ptf1a results in ectopic gene expression and multiple congenital defects in Danforth's short tail mouse. Lugani F, et al. PLoS Genet, 2013. PMID 23437001, Free PMC Article
  5. Systems genetic analysis of hippocampal neuroanatomy and spatial learning in mice. Delprato A, et al. Genes Brain Behav, 2015 Nov. PMID 26449520, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatid development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
armadillo repeat-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081083.2 → NP_001074552.1  armadillo repeat-containing protein 3 isoform 1

    See identical proteins and their annotated locations for NP_001074552.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL929034
    Consensus CDS
    CCDS38052.1
    UniProtKB/Swiss-Prot
    A2AU72, Q8BY67
    UniProtKB/TrEMBL
    B2RWT0
    Related
    ENSMUSP00000110287.3, ENSMUST00000114640.9
    Conserved Domains (4) summary
    cd00020
    Location:145 → 259
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam13646
    Location:152 → 230
    HEAT_2; HEAT repeats
    pfam14381
    Location:739 → 867
    EDR1; Ethylene-responsive protein kinase Le-CTR1
    sd00043
    Location:22 → 52
    ARM; armadillo repeat [structural motif]

  2. NM_001271563.1 → NP_001258492.1  armadillo repeat-containing protein 3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame acceptor splice site and lacks an alternate in-frame exon in the coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AL929034
    Consensus CDS
    CCDS70983.1
    UniProtKB/TrEMBL
    A2AU71, B2RWT0
    Related
    ENSMUSP00000048784.7, ENSMUST00000049255.7
    Conserved Domains (4) summary
    cd00020
    Location:145 → 259
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam13646
    Location:152 → 230
    HEAT_2; HEAT repeats
    pfam14381
    Location:727 → 855
    EDR1; Ethylene-responsive protein kinase Le-CTR1
    sd00043
    Location:22 → 52
    ARM; armadillo repeat [structural motif]

  3. NM_001271564.1 → NP_001258493.1  armadillo repeat-containing protein 3 isoform 3

    See identical proteins and their annotated locations for NP_001258493.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the coding region compared to variant 1. It encodes isoform 3, which is shorter than isoform 1.
    Source sequence(s)
    AL929034, BC145013
    UniProtKB/TrEMBL
    B2RWT0, B7ZN53
    Conserved Domains (4) summary
    cd00020
    Location:145 → 259
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam13646
    Location:152 → 230
    HEAT_2; HEAT repeats
    pfam14381
    Location:723 → 851
    EDR1; Ethylene-responsive protein kinase Le-CTR1
    sd00043
    Location:22 → 52
    ARM; armadillo repeat [structural motif]

  4. NM_001271565.1 → NP_001258494.1  armadillo repeat-containing protein 3 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame acceptor splice site and lacks two alternate in-frame exons in the coding region, one of which causes a translational frameshift, compared to variant 1. It encodes isoform 4, which has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL929034
    UniProtKB/TrEMBL
    B2RWT0
    Conserved Domains (3) summary
    cd00020
    Location:145 → 259
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam13646
    Location:152 → 230
    HEAT_2; HEAT repeats
    sd00043
    Location:22 → 52
    ARM; armadillo repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    19203676..19315054
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162568.1 → XP_036018461.1  armadillo repeat-containing protein 3 isoform X1

    UniProtKB/TrEMBL
    B2RWT0
    Conserved Domains (6) summary
    smart00185
    Location:469 → 504
    ARM; Armadillo/beta-catenin-like repeats
    PLN03200
    Location:32 → 182
    PLN03200; cellulose synthase-interactive protein; Provisional
    COG5064
    Location:358 → 504
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:22 → 52
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:143 → 178
    Arm; Armadillo/beta-catenin-like repeat
    pfam14381
    Location:754 → 871
    EDR1; Ethylene-responsive protein kinase Le-CTR1

  2. XM_036162569.1 → XP_036018462.1  armadillo repeat-containing protein 3 isoform X2

    UniProtKB/TrEMBL
    B2RWT0
    Conserved Domains (5) summary
    smart00185
    Location:469 → 504
    ARM; Armadillo/beta-catenin-like repeats
    PLN03200
    Location:32 → 182
    PLN03200; cellulose synthase-interactive protein; Provisional
    COG5064
    Location:358 → 504
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:22 → 52
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:143 → 178
    Arm; Armadillo/beta-catenin-like repeat
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2AU72.1 GenPept UniProtKB/Swiss-Prot:A2AU72

Gene LinkOut

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