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Spata16 spermatogenesis associated 16 [ Mus musculus (house mouse) ]

Gene ID: 70862, updated on 5-Mar-2024

Summary

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Official Symbol
Spata16provided by MGI
Official Full Name
spermatogenesis associated 16provided by MGI
Primary source
MGI:MGI:1918112
See related
Ensembl:ENSMUSG00000039335 AllianceGenome:MGI:1918112
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nyd-sp12; 4921511F01Rik; 4930503K02Rik
Summary
Acts upstream of or within spermatogenesis. Predicted to be located in cytoplasmic vesicle. Predicted to be active in Golgi apparatus. Used to study male infertility. Human ortholog(s) of this gene implicated in spermatogenic failure 6. Orthologous to human SPATA16 (spermatogenesis associated 16). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 54.8) See more
Orthologs
human all
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Genomic context

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Location:
3 A3; 3 10.74 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (26691769..27037398)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (26637620..26983249)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene cullin 2 pseudogene Neighboring gene predicted gene, 57710 Neighboring gene STARR-seq mESC enhancer starr_07216 Neighboring gene STARR-seq mESC enhancer starr_07217 Neighboring gene STARR-seq mESC enhancer starr_07219 Neighboring gene predicted gene, 32458 Neighboring gene STARR-seq mESC enhancer starr_07220 Neighboring gene STARR-seq mESC enhancer starr_07221 Neighboring gene STARR-seq mESC enhancer starr_07222 Neighboring gene ribosomal protein L3 pseudogene Neighboring gene predicted gene, 25152 Neighboring gene ect2 oncogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification and characterization of a novel human testis-specific Golgi protein, NYD-SP12. Xu M, et al. Mol Hum Reprod, 2003 Jan. PMID 12529416
  2. Human Globozoospermia-Related Gene Spata16 Is Required for Sperm Formation Revealed by CRISPR/Cas9-Mediated Mouse Models. Fujihara Y, et al. Int J Mol Sci, 2017 Oct 21. PMID 29065458, Free PMC Article
  3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatid development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
spermatogenesis-associated protein 16
Names
spermatogenesis-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027583.3 → NP_081859.1  spermatogenesis-associated protein 16 isoform 1

    See identical proteins and their annotated locations for NP_081859.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 3' coding region and 3' UTR, compared to variant 2. The resulting isoform (1) has a shorter and distinct C-terminus, compared to isoform 2.
    Source sequence(s)
    BB572700, BC100443
    Consensus CDS
    CCDS38403.1
    UniProtKB/Swiss-Prot
    Q8C636
    Related
    ENSMUSP00000103941.2, ENSMUST00000108305.2
    Conserved Domains (3) summary
    sd00006
    Location:210 → 258
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:178 → 260
    TPR_11; TPR repeat
    pfam15015
    Location:6 → 532
    NYD-SP12_N; Spermatogenesis-associated, N-terminal

  2. NM_029150.4 → NP_083426.1  spermatogenesis-associated protein 16 isoform 2

    See identical proteins and their annotated locations for NP_083426.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2).
    Source sequence(s)
    AC108829, AK076628, BC132205
    Consensus CDS
    CCDS17269.1
    UniProtKB/Swiss-Prot
    Q8C636, Q9D5W9
    Related
    ENSMUSP00000043378.5, ENSMUST00000047005.11
    Conserved Domains (3) summary
    sd00006
    Location:210 → 258
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:178 → 260
    TPR_11; TPR repeat
    pfam15015
    Location:6 → 569
    NYD-SP12_N; Spermatogenesis-associated, N-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    26691769..27037398
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319720.2 → XP_017175209.1  spermatogenesis-associated protein 16 isoform X1

    Conserved Domains (2) summary
    sd00006
    Location:210 → 258
    TPR; TPR repeat [structural motif]
    pfam15015
    Location:5 → 568
    NYD-SP12_N; Spermatogenesis-associated, N-terminal
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C636.1 GenPept UniProtKB/Swiss-Prot:Q8C636

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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