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Slc22a16 solute carrier family 22 (organic cation transporter), member 16 [ Mus musculus (house mouse) ]

Gene ID: 70840, updated on 5-Mar-2024

Summary

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Official Symbol
Slc22a16provided by MGI
Official Full Name
solute carrier family 22 (organic cation transporter), member 16provided by MGI
Primary source
MGI:MGI:1918090
See related
Ensembl:ENSMUSG00000019834 AllianceGenome:MGI:1918090
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CT2; OCT6; OKB1; FLIPT2; 4921504E14Rik
Summary
Predicted to enable amine transmembrane transporter activity and carnitine transmembrane transporter activity. Predicted to be involved in several processes, including acid secretion; flagellated sperm motility; and organic cation transport. Predicted to act upstream of or within carnitine transport. Predicted to be located in cytosol and plasma membrane. Predicted to be integral component of membrane. Orthologous to human SLC22A16 (solute carrier family 22 member 16). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 66.4) See more
Orthologs
human all
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Genomic context

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Location:
10 B1; 10 21.99 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (40446317..40480128)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (40570321..40604132)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_26427 Neighboring gene small nuclear ribonucleoprotein B pseudogene Neighboring gene STARR-seq mESC enhancer starr_26428 Neighboring gene predicted gene, 17795 Neighboring gene D-aspartate oxidase Neighboring gene methyltransferase like 24 Neighboring gene STARR-seq mESC enhancer starr_26430 Neighboring gene STARR-seq mESC enhancer starr_26431 Neighboring gene STARR-seq mESC enhancer starr_26432 Neighboring gene STARR-seq mESC enhancer starr_26433

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Replacement of the Sox10 transcription factor by Sox8 reveals incomplete functional equivalence. Kellerer S, et al. Development, 2006 Aug. PMID 16790476
  2. Sonic hedgehog maintains the identity of cortical interneuron progenitors in the ventral telencephalon. Xu Q, et al. Development, 2005 Nov. PMID 16221724
  3. Sequential phases of cortical specification involve Neurogenin-dependent and -independent pathways. Schuurmans C, et al. EMBO J, 2004 Jul 21. PMID 15229646, Free PMC Article
  4. SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron. Jepsen K, et al. Nature, 2007 Nov 15. PMID 17928865
  5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Clone Names

  • MGC118295

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables amine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables carnitine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables organic cation transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables organic cation transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables spermidine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in acid secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in carnitine transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within carnitine transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in flagellated sperm motility ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in organic cation transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within organic cation transport ISO
Inferred from Sequence Orthology
more info
  
involved_in single fertilization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in spermidine transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
solute carrier family 22 member 16
Names
carnitine transporter 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027572.1 → NP_081848.1  solute carrier family 22 member 16

    See identical proteins and their annotated locations for NP_081848.1

    Status: VALIDATED

    Source sequence(s)
    BC100473
    Consensus CDS
    CCDS23796.1
    UniProtKB/Swiss-Prot
    Q3LVC1, Q497L8
    UniProtKB/TrEMBL
    B2RRB7
    Related
    ENSMUSP00000077428.8, ENSMUST00000078314.14
    Conserved Domains (2) summary
    cd06174
    Location:163 → 525
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:14 → 535
    2A0119; cation transport protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    40446317..40480128
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512850.4 → XP_006512913.1  solute carrier family 22 member 16 isoform X1

    Conserved Domains (1) summary
    cl28910
    Location:18 → 365
    MFS; Major Facilitator Superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q497L8.1 GenPept UniProtKB/Swiss-Prot:Q497L8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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