P2ry12 purinergic receptor P2Y, G-protein coupled 12 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: P2ry12provided by MGI
Official Full Name: purinergic receptor P2Y, G-protein coupled 12provided by MGI
Primary source: MGI:MGI:1918089
See related: Ensembl:ENSMUSG00000036353 AllianceGenome:MGI:1918089
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: P2Y12; 2900079B22Rik; 4921504D23Rik
Summary: Enables G protein-coupled ADP receptor activity and G protein-coupled adenosine receptor activity. Involved in several processes, including cellular response to ATP; regulation of microglial cell migration; and substrate-dependent cell migration, cell extension. Acts upstream of or within several processes, including adenylate cyclase-modulating G protein-coupled receptor signaling pathway; platelet activation; and positive regulation of ion transport. Located in cell body membrane and cell projection membrane. Is expressed in central nervous system and cerebral cortex. Used to study platelet-type bleeding disorder 8. Human ortholog(s) of this gene implicated in asthma; cerebrovascular disease; peripheral artery disease; platelet-type bleeding disorder 8; and type 2 diabetes mellitus. Orthologous to human P2RY12 (purinergic receptor P2Y12). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in cortex adult (RPKM 10.9), frontal lobe adult (RPKM 10.2) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 D; 3 29.01 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (59123692..59170408, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (59216271..59262985, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

APOE4 genotype and aging impair injury-induced microglial behavior in brain slices, including toward Abeta, through P2RY12.
Title: APOE4 genotype and aging impair injury-induced microglial behavior in brain slices, including toward Aβ, through P2RY12.
Purinergic receptor P2Y12 boosts autoimmune hepatitis through hexokinase 2-dependent glycolysis in T cells.
Title: Purinergic receptor P2Y12 boosts autoimmune hepatitis through hexokinase 2-dependent glycolysis in T cells.
Microglial P2Y12 mediates chronic stress-induced synapse loss in the prefrontal cortex and associated behavioral consequences.
Title: Microglial P2Y12 mediates chronic stress-induced synapse loss in the prefrontal cortex and associated behavioral consequences.
D121 Located within the DRY Motif of P2Y12 Is Essential for P2Y12-Mediated Platelet Function.
Title: D121 Located within the DRY Motif of P2Y12 Is Essential for P2Y12-Mediated Platelet Function.
Platelets control liver tumor growth through P2Y12-dependent CD40L release in NAFLD.
Title: Platelets control liver tumor growth through P2Y12-dependent CD40L release in NAFLD.
The dualistic role of the purinergic P2Y12-receptor in an in vivo model of Parkinson's disease: Signalling pathway and novel therapeutic targets.
Title: The dualistic role of the purinergic P2Y12-receptor in an in vivo model of Parkinson's disease: Signalling pathway and novel therapeutic targets.
P2Y12 Inhibition in Murine Myocarditis Results in Reduced Platelet Infiltration and Preserved Ejection Fraction.
Title: P2Y(12) Inhibition in Murine Myocarditis Results in Reduced Platelet Infiltration and Preserved Ejection Fraction.
The P2RY12 receptor promotes VSMC-derived foam cell formation by inhibiting autophagy in advanced atherosclerosis.
Title: The P2RY12 receptor promotes VSMC-derived foam cell formation by inhibiting autophagy in advanced atherosclerosis.
C3G contributes to platelet activation and aggregation by regulating major signaling pathways.
Title: C3G contributes to platelet activation and aggregation by regulating major signaling pathways.
Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling in mice.
Title: Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling in mice.

Submit: New GeneRIF Correction See all GeneRIFs (71)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (4) 1 citation

General gene information

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Markers

BF392058 (e-PCR)
- UniSTS:243461

BE134084 (e-PCR)
- UniSTS:207490

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled ADP receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables G protein-coupled ADP receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled adenosine receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables G protein-coupled purinergic nucleotide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled adenosine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood coagulation	IEA Inferred from Electronic Annotation more info
involved_in blood coagulation	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in calcium-mediated signaling using extracellular calcium source	ISO Inferred from Sequence Orthology more info
involved_in cell projection organization	ISO Inferred from Sequence Orthology more info
involved_in cellular response to ATP	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to ATP	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to organic cyclic compound	IDA Inferred from Direct Assay more info	PubMed
involved_in cerebral cortex radial glia-guided migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of establishment of localization in cell	IGI Inferred from Genetic Interaction more info	PubMed
involved_in glial cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hemostasis	IEA Inferred from Electronic Annotation more info
involved_in lamellipodium assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of monoatomic ion transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of norepinephrine secretion	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within platelet activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in platelet aggregation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of integrin activation by cell surface receptor linked signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of microglial cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of monoatomic ion transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ruffle assembly	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in regulation of microglial cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in response to axon injury	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in substrate-dependent cell migration, cell extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in visual system development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
located_in caveola	ISO Inferred from Sequence Orthology more info
located_in cell body membrane	IGI Inferred from Genetic Interaction more info	PubMed
located_in cell projection membrane	IGI Inferred from Genetic Interaction more info	PubMed
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IC Inferred by Curator more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: P2Y purinoceptor 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357007.1 → NP_001343936.1 P2Y purinoceptor 12

Status: VALIDATED

Source sequence(s)

AC122038, CN691066

Consensus CDS

CCDS17373.1

UniProtKB/Swiss-Prot

Q9CPV9

UniProtKB/TrEMBL

Q546L4, Q8BZV8

Related

ENSMUSP00000143521.2, ENSMUST00000199609.2

Conserved Domains (1) summary

cd15150
Location:32 → 315

7tmA_P2Y12; P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001357008.1 → NP_001343937.1 P2Y purinoceptor 12

Status: VALIDATED

Source sequence(s)

AC122038

Consensus CDS

CCDS17373.1

UniProtKB/Swiss-Prot

Q9CPV9

UniProtKB/TrEMBL

Q546L4, Q8BZV8

Related

ENSMUSP00000143036.2, ENSMUST00000196583.5

Conserved Domains (1) summary

cd15150
Location:32 → 315

7tmA_P2Y12; P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001357010.1 → NP_001343939.1 P2Y purinoceptor 12

Status: VALIDATED

Source sequence(s)

AC122038

Consensus CDS

CCDS17373.1

UniProtKB/Swiss-Prot

Q9CPV9

UniProtKB/TrEMBL

Q546L4, Q8BZV8

Related

ENSMUSP00000126819.2, ENSMUST00000170388.6

Conserved Domains (1) summary

cd15150
Location:32 → 315

7tmA_P2Y12; P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_027571.4 → NP_081847.3 P2Y purinoceptor 12

See identical proteins and their annotated locations for NP_081847.3

Status: VALIDATED

Source sequence(s)

AC122038, AK013804, AK014807, AK033448

Consensus CDS

CCDS17373.1

UniProtKB/Swiss-Prot

Q9CPV9

UniProtKB/TrEMBL

Q546L4, Q8BZV8

Related

ENSMUSP00000051353.8, ENSMUST00000050360.14

Conserved Domains (1) summary

cd15150
Location:32 → 315

7tmA_P2Y12; P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

59123692..59170408 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036163310.1 → XP_036019203.1 P2Y purinoceptor 12 isoform X1

UniProtKB/Swiss-Prot

Q9CPV9

UniProtKB/TrEMBL

Q546L4, Q8BZV8

Conserved Domains (1) summary

cd15150
Location:32 → 315

7tmA_P2Y12; P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_036163311.1 → XP_036019204.1 P2Y purinoceptor 12 isoform X1

UniProtKB/Swiss-Prot

Q9CPV9

UniProtKB/TrEMBL

Q546L4, Q8BZV8

Conserved Domains (1) summary

cd15150
Location:32 → 315

7tmA_P2Y12; P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors