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Ubr5 ubiquitin protein ligase E3 component n-recognin 5 [ Mus musculus (house mouse) ]

Gene ID: 70790, updated on 21-Apr-2024

Summary

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Official Symbol
Ubr5provided by MGI
Official Full Name
ubiquitin protein ligase E3 component n-recognin 5provided by MGI
Primary source
MGI:MGI:1918040
See related
Ensembl:ENSMUSG00000037487 AllianceGenome:MGI:1918040
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Edd; Edd1
Summary
Predicted to enable protein domain specific binding activity and ubiquitin-ubiquitin ligase activity. Acts upstream of or within negative regulation of interleukin-17 production and regulation of protein stability. Predicted to be located in cytosol; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Is expressed in cranial ganglion; nervous system; sensory organ; submandibular gland primordium; and vibrissa. Human ortholog(s) of this gene implicated in invasive ductal carcinoma. Orthologous to human UBR5 (ubiquitin protein ligase E3 component n-recognin 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 22.8), CNS E11.5 (RPKM 15.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 B3.1; 15 15.1 cM
Exon count:
60
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (37966421..38084103, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (37967328..38078862, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35019 Neighboring gene STARR-positive B cell enhancer ABC_E7364 Neighboring gene ribonucleotide reductase M2 B (TP53 inducible) Neighboring gene STARR-positive B cell enhancer mm9_chr15:37889822-37890123 Neighboring gene STARR-positive B cell enhancer ABC_E9416 Neighboring gene 60S ribosomal protein L23a pseudogene Neighboring gene predicted gene, 49085 Neighboring gene STARR-seq mESC enhancer starr_38435 Neighboring gene STARR-seq mESC enhancer starr_38437 Neighboring gene predicted gene, 22353 Neighboring gene STARR-seq mESC enhancer starr_38438 Neighboring gene predicted gene, 35081 Neighboring gene predicted gene, 35167

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Knockdown of the E3 ubiquitin ligase UBR5 and its role in skeletal muscle anabolism. Hughes DC, et al. Am J Physiol Cell Physiol, 2021 Jan 1. PMID 33052072
  2. An analysis and validation pipeline for large-scale RNAi-based screens. Plank M, et al. Sci Rep, 2013. PMID 23326633, Free PMC Article
  3. Tumor derived UBR5 promotes ovarian cancer growth and metastasis through inducing immunosuppressive macrophages. Song M, et al. Nat Commun, 2020 Dec 8. PMID 33293516, Free PMC Article
  4. UBR5 HECT domain mutations identified in mantle cell lymphoma control maturation of B cells. Swenson SA, et al. Blood, 2020 Jul 16. PMID 32325489, Free PMC Article
  5. MicroRNA-1224 Splicing CircularRNA-Filip1l in an Ago2-Dependent Manner Regulates Chronic Inflammatory Pain via Targeting Ubr5. Pan Z, et al. J Neurosci, 2019 Mar 13. PMID 30651325, Free PMC Article

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. UBR5 promotes antiviral immunity by disengaging the transcriptional brake on RIG-I like receptors.
    Title: UBR5 promotes antiviral immunity by disengaging the transcriptional brake on RIG-I like receptors.
  2. Ubiquitin-protein ligase Ubr5 cooperates with hedgehog signalling to promote skeletal tissue homeostasis.
    Title: Ubiquitin-protein ligase Ubr5 cooperates with hedgehog signalling to promote skeletal tissue homeostasis.
  3. UBR5 HECT domain mutations identified in mantle cell lymphoma control maturation of B cells.
    Title: UBR5 HECT domain mutations identified in mantle cell lymphoma control maturation of B cells.
  4. Knockdown of the E3 ubiquitin ligase UBR5 and its role in skeletal muscle anabolism.
    Title: Knockdown of the E3 ubiquitin ligase UBR5 and its role in skeletal muscle anabolism.
  5. Tumor derived UBR5 promotes ovarian cancer growth and metastasis through inducing immunosuppressive macrophages.
    Title: Tumor derived UBR5 promotes ovarian cancer growth and metastasis through inducing immunosuppressive macrophages.
  6. Data suggest that miRNA-1224-mediated and Ago2-dependent modulation of spinal circRNA-Filip1l expression regulates nociception via targeting Ubr5, revealing a novel epigenetic mechanism of interaction between miRNA and circRNA in chronic inflammation pain.
    Title: MicroRNA-1224 Splicing CircularRNA-Filip1l in an Ago2-Dependent Manner Regulates Chronic Inflammatory Pain via Targeting Ubr5.
  7. Hence, while loss of UBR5 perturbed Hedgehog signalling in the developing limb, there were no obvious morphological defects.
    Title: Use of a Conditional Ubr5 Mutant Allele to Investigate the Role of an N-End Rule Ubiquitin-Protein Ligase in Hedgehog Signalling and Embryonic Limb Development.
  8. Findings unveil UBR5 as a novel and critical regulator of tumor growth, metastasis, and immune response in triple negative breast cancer.
    Title: E3 Ubiquitin Ligase UBR5 Drives the Growth and Metastasis of Triple-Negative Breast Cancer.
  9. UBR5-mediated ATMIN ubiquitination is a vital event for ATM pathway selection and activation in response to DNA damage
    Title: UBR5-mediated ubiquitination of ATMIN is required for ionizing radiation-induced ATM signaling and function.
  10. a novel function of RIP1 kinase involving its interaction with EDD to regulate JNK activation and TNFalpha production.
    Title: A novel role for RIP1 kinase in mediating TNFα production.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • mKIAA0896, D030042K14, 4432411E13Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-ubiquitin ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-ubiquitin ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair-dependent chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in heterochromatin boundary formation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of interleukin-17 production IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in positive regulation of protein import into nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in progesterone receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of protein stability IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase UBR5
Names
E3 ubiquitin-protein ligase, HECT domain-containing 1
HECT-type E3 ubiquitin transferase UBR5
extraembryonic development
hyperplastic discs protein homolog
NP_001074828.2
NP_001106192.1
XP_006520242.1
XP_006520243.1
XP_006520244.1
XP_006520245.1
XP_030104623.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081359.3 → NP_001074828.2  E3 ubiquitin-protein ligase UBR5 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK014485, AK162029, AY550908, CB527808, CJ063125, DV047629
    Consensus CDS
    CCDS49595.1
    UniProtKB/Swiss-Prot
    Q698K9, Q6PEQ8, Q6PFQ9, Q80TP3, Q80VL4, Q810V6, Q9CXE9
    UniProtKB/TrEMBL
    A0A2I3BQS6
    Related
    ENSMUSP00000154293.2, ENSMUST00000226414.2
    Conserved Domains (5) summary
    smart00396
    Location:1177 → 1244
    ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
    smart00517
    Location:2389 → 2452
    PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
    smart00119
    Location:2467 → 2795
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00632
    Location:2500 → 2798
    HECT; HECT-domain (ubiquitin-transferase)
    pfam11547
    Location:179 → 226
    E3_UbLigase_EDD; E3 ubiquitin ligase EDD

  2. NM_001112721.2 → NP_001106192.1  E3 ubiquitin-protein ligase UBR5 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AK014485, AK162029, AY550908, CB527808, CJ063125
    Consensus CDS
    CCDS88751.1
    UniProtKB/Swiss-Prot
    Q698K9, Q6PEQ8, Q6PFQ9, Q80TP3, Q80VL4, Q810V6, Q9CXE9
    UniProtKB/TrEMBL
    E9Q2H1
    Related
    ENSMUSP00000105965.4, ENSMUST00000110336.4
    Conserved Domains (5) summary
    smart00396
    Location:1171 → 1238
    ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
    smart00517
    Location:2383 → 2446
    PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
    smart00119
    Location:2461 → 2789
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00632
    Location:2494 → 2792
    HECT; HECT-domain (ubiquitin-transferase)
    pfam11547
    Location:179 → 226
    E3_UbLigase_EDD; E3 ubiquitin ligase EDD

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    37966421..38084103 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520182.5 → XP_006520245.1  E3 ubiquitin-protein ligase UBR5 isoform X4

    UniProtKB/Swiss-Prot
    Q698K9, Q6PEQ8, Q6PFQ9, Q80TP3, Q80VL4, Q810V6, Q9CXE9
    Conserved Domains (4) summary
    smart00396
    Location:1171 → 1238
    ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
    smart00517
    Location:2385 → 2448
    PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
    smart00119
    Location:2463 → 2791
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd14423
    Location:184 → 230
    CUE_UBR5; CUE domain found in E3 ubiquitin-protein ligase UBR5 and similar proteins

  2. XM_006520181.5 → XP_006520244.1  E3 ubiquitin-protein ligase UBR5 isoform X3

    UniProtKB/Swiss-Prot
    Q698K9, Q6PEQ8, Q6PFQ9, Q80TP3, Q80VL4, Q810V6, Q9CXE9
    Conserved Domains (4) summary
    smart00396
    Location:1177 → 1244
    ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
    smart00517
    Location:2389 → 2452
    PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
    smart00119
    Location:2498 → 2793
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd14423
    Location:184 → 230
    CUE_UBR5; CUE domain found in E3 ubiquitin-protein ligase UBR5 and similar proteins

  3. XM_006520180.5 → XP_006520243.1  E3 ubiquitin-protein ligase UBR5 isoform X2

    UniProtKB/Swiss-Prot
    Q698K9, Q6PEQ8, Q6PFQ9, Q80TP3, Q80VL4, Q810V6, Q9CXE9
    Conserved Domains (4) summary
    smart00396
    Location:1177 → 1244
    ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
    smart00517
    Location:2391 → 2454
    PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
    smart00119
    Location:2500 → 2795
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd14423
    Location:184 → 230
    CUE_UBR5; CUE domain found in E3 ubiquitin-protein ligase UBR5 and similar proteins

  4. XM_006520179.5 → XP_006520242.1  E3 ubiquitin-protein ligase UBR5 isoform X1

    UniProtKB/Swiss-Prot
    Q698K9, Q6PEQ8, Q6PFQ9, Q80TP3, Q80VL4, Q810V6, Q9CXE9
    Conserved Domains (4) summary
    smart00396
    Location:1177 → 1244
    ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
    smart00517
    Location:2391 → 2454
    PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
    smart00119
    Location:2469 → 2797
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd14423
    Location:184 → 230
    CUE_UBR5; CUE domain found in E3 ubiquitin-protein ligase UBR5 and similar proteins

  5. XM_030248763.2 → XP_030104623.1  E3 ubiquitin-protein ligase UBR5 isoform X5

    Conserved Domains (3) summary
    smart00396
    Location:187 → 254
    ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
    smart00517
    Location:1401 → 1464
    PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
    smart00119
    Location:1479 → 1807
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

RNA

  1. XR_001781565.3 RNA Sequence

  2. XR_383833.5 RNA Sequence

  3. XR_383834.5 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_027553.1: Suppressed sequence

    Description
    NM_027553.1: This RefSeq was permanently suppressed because the CDS was partial.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80TP3.2 GenPept UniProtKB/Swiss-Prot:Q80TP3

Gene LinkOut

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