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Dennd1c DENN domain containing 1C [ Mus musculus (house mouse) ]

Gene ID: 70785, updated on 5-Mar-2024

Summary

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Official Symbol
Dennd1cprovided by MGI
Official Full Name
DENN domain containing 1Cprovided by MGI
Primary source
MGI:MGI:1918035
See related
Ensembl:ENSMUSG00000002668 AllianceGenome:MGI:1918035
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4432409M07Rik
Summary
Predicted to enable guanyl-nucleotide exchange factor activity and phosphatidylinositol phosphate binding activity. Predicted to be involved in endocytic recycling and endocytosis. Predicted to be located in centrosome and nucleoplasm. Predicted to be active in cytosol and intracellular membrane-bounded organelle. Orthologous to human DENND1C (DENN domain containing 1C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thymus adult (RPKM 32.6), spleen adult (RPKM 31.1) and 12 other tissues See more
Orthologs
human all
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Genomic context

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See Dennd1c in Genome Data Viewer
Location:
17 D; 17 29.65 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (57373051..57385518, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (57066051..57078529, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23 Neighboring gene STARR-positive B cell enhancer ABC_E3211 Neighboring gene crumbs family member 3 Neighboring gene tubulin, beta 4A class IVA Neighboring gene predicted gene 11110 Neighboring gene predicted gene, 46589

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  2. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC30613

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DENN domain-containing protein 1C
Names
DENN/MADD domain containing 1C
connecdenn 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001384107.1 → NP_001371036.1  DENN domain-containing protein 1C isoform 2

    Status: VALIDATED

    Source sequence(s)
    CT571247
    Conserved Domains (3) summary
    smart00801
    Location:331 → 397
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:91 → 299
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:13 → 87
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  2. NM_001384108.1 → NP_001371037.1  DENN domain-containing protein 1C isoform 3

    Status: VALIDATED

    Source sequence(s)
    CT571247
    Conserved Domains (3) summary
    smart00801
    Location:330 → 396
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:91 → 299
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:13 → 87
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  3. NM_001384109.1 → NP_001371038.1  DENN domain-containing protein 1C isoform 4

    Status: VALIDATED

    Source sequence(s)
    CT571247
    Conserved Domains (3) summary
    smart00801
    Location:330 → 396
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:91 → 299
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:13 → 87
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  4. NM_001384110.1 → NP_001371039.1  DENN domain-containing protein 1C isoform 5

    Status: VALIDATED

    Source sequence(s)
    CT571247
    Conserved Domains (3) summary
    smart00801
    Location:325 → 391
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:91 → 293
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:13 → 87
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  5. NM_001384111.1 → NP_001371040.1  DENN domain-containing protein 1C isoform 6

    Status: VALIDATED

    Source sequence(s)
    CT571247
    Conserved Domains (2) summary
    smart00799
    Location:91 → 293
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:13 → 87
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  6. NM_153551.2 → NP_705779.1  DENN domain-containing protein 1C isoform 1

    See identical proteins and their annotated locations for NP_705779.1

    Status: VALIDATED

    Source sequence(s)
    CT571247
    Consensus CDS
    CCDS37669.1
    UniProtKB/Swiss-Prot
    Q8CFK6, Q9CXF1
    Related
    ENSMUSP00000011623.8, ENSMUST00000011623.9
    Conserved Domains (3) summary
    smart00801
    Location:325 → 391
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:91 → 293
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:13 → 87
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    57373051..57385518 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524901.3 → XP_006524964.1  DENN domain-containing protein 1C isoform X2

    Conserved Domains (3) summary
    smart00801
    Location:331 → 397
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:91 → 299
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:13 → 87
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  2. XM_006524899.4 → XP_006524962.1  DENN domain-containing protein 1C isoform X1

    Conserved Domains (3) summary
    smart00801
    Location:330 → 396
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:90 → 298
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:12 → 86
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  3. XM_011246601.3 → XP_011244903.1  DENN domain-containing protein 1C isoform X3

    Conserved Domains (3) summary
    smart00801
    Location:284 → 350
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:44 → 252
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    cl04085
    Location:16 → 40
    uDENN; uDENN domain

RNA

  1. XR_003952178.2 RNA Sequence

  2. XR_003952179.2 RNA Sequence

    Related
    ENSMUST00000233564.2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CFK6.1 GenPept UniProtKB/Swiss-Prot:Q8CFK6

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