Ggnbp1 gametogenetin binding protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ggnbp1provided by MGI
Official Full Name: gametogenetin binding protein 1provided by MGI
Primary source: MGI:MGI:3055306
See related: Ensembl:ENSMUSG00000048731 AllianceGenome:MGI:3055306
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mdf; 0610031G08Rik
Summary: Involved in mitochondrial fission. Located in Golgi apparatus; mitochondrial intermembrane space; and plasma membrane. Is expressed in ductus deferens; epididymis; jejunum; and testis. Orthologous to human GGNBP1 (gametogenetin binding protein 1 (pseudogene)). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 178.0) and kidney adult (RPKM 10.5) See more
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Genomic context

Location:: 17 A3.3; 17 13.6 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (27237009..27255352)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (27018035..27036378)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GGNBP1 ensures proper spermiogenesis in response to stress in mice.
Title: GGNBP1 ensures proper spermiogenesis in response to stress in mice.
GGNBP1 is involved in spermatogenesis by modifying mitochondrial dynamics and morphology.
Title: A novel potential role for gametogenetin-binding protein 1 (GGNBP1) in mitochondrial morphogenesis during spermatogenesis in mice.
A testicular germ cell-specific protein interacting with GGN1. The protein seems to associate with the membrane system in the germ cell.
Title: Identification and characterization of a novel testicular germ cell-specific gene Ggnbp1.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Bak1 (e-PCR), detects polymorphism
- UniSTS:141155

D17Jcs15 (e-PCR), detects polymorphism
- UniSTS:259264

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial fission	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial intermembrane space	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: gametogenetin-binding protein 1

Names: deubiquitinating enzyme Usp15; gametogenin binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001251881.1 → NP_001238810.1 gametogenetin-binding protein 1 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an exon and includes two alternate exons in the 5' UTR and CDS, compared to variant 1. It encodes isoform b, which is shorter and has a distinct N-terminus, compared to isoform a.

Source sequence(s)

AA388242, CF585840, CO041745

Consensus CDS

CCDS57061.1

UniProtKB/TrEMBL

D3Z3W4

Related

ENSMUSP00000113880.2, ENSMUST00000122106.9

Conserved Domains (1) summary

pfam14836
Location:173 → 260

Ubiquitin_3; Ubiquitin-like domain
NM_027544.2 → NP_081820.2 gametogenetin-binding protein 1 isoform a

See identical proteins and their annotated locations for NP_081820.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).

Source sequence(s)

AK077129, AY141192, BB018101

Consensus CDS

CCDS28559.1

UniProtKB/Swiss-Prot

B9WZ58, Q6K1E7, Q8C5T9

Related

ENSMUSP00000051800.7, ENSMUST00000053683.7

Conserved Domains (1) summary

pfam14836
Location:281 → 368

Ubiquitin_3; Ubiquitin-like domain