U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Gpr173 G-protein coupled receptor 173 [ Mus musculus (house mouse) ]

Gene ID: 70771, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Gpr173provided by MGI
Official Full Name
G-protein coupled receptor 173provided by MGI
Primary source
MGI:MGI:1918021
See related
Ensembl:ENSMUSG00000056679 AllianceGenome:MGI:1918021
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sreb3; 3230401K02Rik
Summary
Enables gonadotropin-releasing hormone receptor activity. Acts upstream of or within negative regulation of neuron migration. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in gut; nervous system; and neural retina. Orthologous to human GPR173 (G protein-coupled receptor 173). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in whole brain E14.5 (RPKM 3.7), CNS E14 (RPKM 2.9) and 19 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
X F3; X 68.46 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (151126594..151151763, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (152343598..152368736, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene Kdm5c adjacent non-coding transcript Neighboring gene STARR-positive B cell enhancer mm9_chrX:148771022-148771323 Neighboring gene TSPY-like 2 Neighboring gene RIKEN cDNA 3010001F23 gene Neighboring gene STARR-seq mESC enhancer starr_48095 Neighboring gene actin, beta pseudogene Neighboring gene actin, beta, pseudogene 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A Novel CCK Receptor GPR173 Mediates Potentiation of GABAergic Inhibition. He L, et al. J Neurosci, 2023 Mar 29. PMID 36813575, Free PMC Article
  2. Regulation of Gpr173 expression, a putative phoenixin receptor, by saturated fatty acid palmitate and endocrine-disrupting chemical bisphenol A through a p38-mediated mechanism in immortalized hypothalamic neurons. McIlwraith EK, et al. Mol Cell Endocrinol, 2019 Apr 5. PMID 30716364
  3. The metabolite GnRH-(1-5) inhibits the migration of immortalized GnRH neurons. Larco DO, et al. Endocrinology, 2013 Feb. PMID 23321696
  4. The G protein-coupled receptor repertoires of human and mouse. Vassilatis DK, et al. Proc Natl Acad Sci U S A, 2003 Apr 15. PMID 12679517, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A Novel CCK Receptor GPR173 Mediates Potentiation of GABAergic Inhibition.
    Title: A Novel CCK Receptor GPR173 Mediates Potentiation of GABAergic Inhibition.
  2. Study reports that Gpr173 is downregulated by palmitate and BPA in hypothalamic neuronal cell lines and primary culture, both partially mediated by MAPK p38 pathway. Also, palmitate impairs the capacity of the GPR173 putative ligand, PNX, to activate signaling in hypothalamic neurons. These findings contribute to the understanding of how fats and endocrine disruptors affect reproductive function.
    Title: Regulation of Gpr173 expression, a putative phoenixin receptor, by saturated fatty acid palmitate and endocrine-disrupting chemical bisphenol A through a p38-mediated mechanism in immortalized hypothalamic neurons.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables gonadotropin-releasing hormone receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables gonadotropin-releasing hormone receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of neuron migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of neuron migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
probable G-protein coupled receptor 173
Names
G protein-coupled receptor SREB3
super conserved receptor expressed in brain 3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313748.2 → NP_001300677.1  probable G-protein coupled receptor 173

    Status: VALIDATED

    Source sequence(s)
    AL731727, BC096520, BU703861, CB245455, CK627285
    Consensus CDS
    CCDS30475.1
    UniProtKB/Swiss-Prot
    A2AHI2, Q4VA66, Q6PI62
    Conserved Domains (2) summary
    cd14964
    Location:24 → 50
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:23 → 351
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. NM_001359449.1 → NP_001346378.1  probable G-protein coupled receptor 173

    Status: VALIDATED

    Source sequence(s)
    AL731727, CK627285
    Consensus CDS
    CCDS30475.1
    UniProtKB/Swiss-Prot
    A2AHI2, Q4VA66, Q6PI62
    Conserved Domains (2) summary
    cd14964
    Location:24 → 50
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:23 → 351
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  3. NM_001359450.1 → NP_001346379.1  probable G-protein coupled receptor 173

    Status: VALIDATED

    Source sequence(s)
    AL731727, CK627285
    Consensus CDS
    CCDS30475.1
    UniProtKB/Swiss-Prot
    A2AHI2, Q4VA66, Q6PI62
    Conserved Domains (2) summary
    cd14964
    Location:24 → 50
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:23 → 351
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  4. NM_027543.5 → NP_081819.2  probable G-protein coupled receptor 173

    See identical proteins and their annotated locations for NP_081819.2

    Status: VALIDATED

    Source sequence(s)
    AL731727, BC096520, BU703861, CK627285
    Consensus CDS
    CCDS30475.1
    UniProtKB/Swiss-Prot
    A2AHI2, Q4VA66, Q6PI62
    Related
    ENSMUSP00000065533.6, ENSMUST00000070316.12
    Conserved Domains (2) summary
    cd14964
    Location:24 → 50
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:23 → 351
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RNA

  1. NR_132633.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AI838338, AL731727, BU703861
    Related
    ENSMUST00000137840.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    151126594..151151763 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247871.4 → XP_011246173.1  probable G-protein coupled receptor 173 isoform X1

    See identical proteins and their annotated locations for XP_011246173.1

    UniProtKB/Swiss-Prot
    A2AHI2, Q4VA66, Q6PI62
    Conserved Domains (2) summary
    cd14964
    Location:24 → 50
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:23 → 351
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PI62.1 GenPept UniProtKB/Swiss-Prot:Q6PI62

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous