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Dclk2 doublecortin-like kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 70762, updated on 21-Apr-2024

Summary

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Official Symbol
Dclk2provided by MGI
Official Full Name
doublecortin-like kinase 2provided by MGI
Primary source
MGI:MGI:1918012
See related
Ensembl:ENSMUSG00000028078 AllianceGenome:MGI:1918012
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CL2; CLICK2; Dcamkl2; Click-II; 6330415M09Rik
Summary
This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmoduline-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. This gene and the DCX gene, another family member, share function in the establishment of hippocampal organization and their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010]
Expression
Biased expression in whole brain E14.5 (RPKM 41.0), CNS E14 (RPKM 37.3) and 11 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 F1; 3 37.88 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (86693457..86828292, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (86786150..86920952, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene LPS-responsive beige-like anchor Neighboring gene thymosin, beta 10 pseudogene Neighboring gene STARR-seq mESC enhancer starr_08131 Neighboring gene predicted gene, 52625 Neighboring gene STARR-seq mESC enhancer starr_08132 Neighboring gene STARR-positive B cell enhancer ABC_E6065 Neighboring gene STARR-seq mESC enhancer starr_08133 Neighboring gene predicted gene, 46810 Neighboring gene STARR-seq mESC enhancer starr_08138 Neighboring gene STARR-seq mESC enhancer starr_08141 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:86790904-86791087 Neighboring gene predicted gene, 23376 Neighboring gene CD1d2 antigen

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Structural studies of the doublecortin family of MAPs. Fourniol F, et al. Methods Cell Biol, 2013. PMID 23973064
  2. Doublecortin-like kinase enhances dendritic remodelling and negatively regulates synapse maturation. Shin E, et al. Nat Commun, 2013. PMID 23385585, Free PMC Article
  3. Doublecortin-Like Kinases Promote Neuronal Survival and Induce Growth Cone Reformation via Distinct Mechanisms. Nawabi H, et al. Neuron, 2015 Nov 18. PMID 26526391, Free PMC Article
  4. Mice lacking doublecortin and doublecortin-like kinase 2 display altered hippocampal neuronal maturation and spontaneous seizures. Kerjan G, et al. Proc Natl Acad Sci U S A, 2009 Apr 21. PMID 19342486, Free PMC Article
  5. Alternative transcripts of Dclk1 and Dclk2 and their expression in doublecortin knockout mice. Tuy FP, et al. Dev Neurosci, 2008. PMID 18075264

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dclk2 promotes axonal regeneration, neuronal survival, and growth core reformation via microtubule stabilization, prevention of F-actin destabilization and synergy with mTOR.
    Title: Doublecortin-Like Kinases Promote Neuronal Survival and Induce Growth Cone Reformation via Distinct Mechanisms.
  2. Doublecortin-like kinases are critical regulators of dendritic development by means of their specific targeting to the distal dendrites, and their local control of dendritic growth and synapse maturation.
    Title: Doublecortin-like kinase enhances dendritic remodelling and negatively regulates synapse maturation.
  3. Dcx; Dclk2-null mice display frequent spontaneous seizures that originate in the hippocampus, with most animals dying in the first few months of life.
    Title: Mice lacking doublecortin and doublecortin-like kinase 2 display altered hippocampal neuronal maturation and spontaneous seizures.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within hippocampus development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within microtubule cytoskeleton organization IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of protein localization to nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of protein localization to nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within pyramidal neuron development IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase DCLK2
Names
caMK-like CREB regulatory kinase 2
doublecortin and CaM kinase-like 2
doublecortin-like and CAM kinase-like 2
NP_001182425.1
NP_001182426.1
NP_001182427.1
NP_001182428.1
NP_001182429.1
NP_001344389.1
NP_081815.3
XP_006502129.1
XP_006502130.1
XP_006502131.1
XP_006502132.1
XP_006502133.1
XP_006502134.1
XP_006502135.1
XP_006502136.1
XP_006502137.1
XP_006502138.1
XP_006502139.1
XP_006502140.1
XP_006502141.1
XP_011238528.1
XP_011238529.1
XP_017175208.1
XP_030108678.1
XP_030108679.1
XP_030108680.1
XP_030108681.1
XP_030108682.1
XP_030108683.1
XP_036019200.1
XP_036019201.1
XP_036019202.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195496.1 → NP_001182425.1  serine/threonine-protein kinase DCLK2 isoform 1

    See identical proteins and their annotated locations for NP_001182425.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is an exon-5-containing transcript (PMIDs:15611072 and 18075264), and encodes the longest isoform (1).
    Source sequence(s)
    AC102164, AC127237, AC132346
    UniProtKB/TrEMBL
    A0A0A6YX71
    Conserved Domains (3) summary
    smart00220
    Location:408 → 665
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00537
    Location:67 → 157
    DCX; Domain in the Doublecortin (DCX) gene product
    cl21453
    Location:406 → 664
    PKc_like; Protein Kinases, catalytic domain

  2. NM_001195497.1 → NP_001182426.1  serine/threonine-protein kinase DCLK2 isoform 3

    See identical proteins and their annotated locations for NP_001182426.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) is an exon-5-lacking transcript (PMIDs:15611072 and 18075264). It lacks an in-frame coding exon, as compared to variant 1. The resulting isoform (3) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AK049179, BC056921, BQ771344, BY361646
    Consensus CDS
    CCDS79936.1
    UniProtKB/TrEMBL
    A0A0A6YX71
    Related
    ENSMUSP00000142267.2, ENSMUST00000195561.6
    Conserved Domains (3) summary
    smart00220
    Location:392 → 649
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00537
    Location:67 → 157
    DCX; Domain in the Doublecortin (DCX) gene product
    cl21453
    Location:390 → 648
    PKc_like; Protein Kinases, catalytic domain

  3. NM_001195498.1 → NP_001182427.1  serine/threonine-protein kinase DCLK2 isoform 4

    See identical proteins and their annotated locations for NP_001182427.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) is an exon-5-containing and exon-17-containing transcript (PMIDs:15611072 and 18075264), and represents the longest transcript. It has an additional 3 nts at an alternate splice site and an additional exon in the 3' region, which results in frame-shift, as compared to variant 1. The resulting isoform (4) has an extra aa in the middle region and has a shorter and different C-terminus, as compared to isoform 1.
    Source sequence(s)
    AC102164, AC127237, AC132346
    UniProtKB/TrEMBL
    A0A0A6YX71
    Conserved Domains (3) summary
    smart00220
    Location:409 → 666
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00537
    Location:67 → 157
    DCX; Domain in the Doublecortin (DCX) gene product
    cl21453
    Location:407 → 665
    PKc_like; Protein Kinases, catalytic domain

  4. NM_001195499.1 → NP_001182428.1  serine/threonine-protein kinase DCLK2 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) is an exon-5-containing and exon-17-containing transcript (PMIDs:15611072 and 18075264). It has an additional exon in the 3' region, which results in frame-shift, as compared to variant 1. The resulting isoform (5) has a shorter and different C-terminus, as compared to isoform 1.
    Source sequence(s)
    AC102164, AC127237, AC132346
    UniProtKB/TrEMBL
    A0A0A6YX71
    Conserved Domains (3) summary
    smart00220
    Location:408 → 665
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00537
    Location:67 → 157
    DCX; Domain in the Doublecortin (DCX) gene product
    cl21453
    Location:406 → 664
    PKc_like; Protein Kinases, catalytic domain

  5. NM_001195500.2 → NP_001182429.1  serine/threonine-protein kinase DCLK2 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) is an exon-5-lacking transcript (PMIDs:15611072 and 18075264). It lacks an internal exon and several 3' exons, but has an alternate 3' segment, as compared to variant 1. The resulting isoform (6) lacks an internal segment and is C-terminal truncated, as compared to isoform 1.
    Source sequence(s)
    AK049126, BQ771344
    Consensus CDS
    CCDS79935.1
    UniProtKB/TrEMBL
    A0A0A6YWI6, A0A0A6YX33
    Related
    ENSMUSP00000141816.2, ENSMUST00000194452.2
    Conserved Domains (3) summary
    smart00220
    Location:392 → 590
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00537
    Location:67 → 157
    DCX; Domain in the Doublecortin (DCX) gene product
    cl21453
    Location:390 → 590
    PKc_like; Protein Kinases, catalytic domain

  6. NM_001357460.1 → NP_001344389.1  serine/threonine-protein kinase DCLK2 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC102164, AC127237, AC132346
    UniProtKB/TrEMBL
    A0A0A6YX71
    Conserved Domains (2) summary
    smart00537
    Location:67 → 157
    DCX; Domain in the Doublecortin (DCX) gene product
    cl21453
    Location:407 → 665
    PKc_like; Protein Kinases, catalytic domain

  7. NM_027539.5 → NP_081815.3  serine/threonine-protein kinase DCLK2 isoform 2

    See identical proteins and their annotated locations for NP_081815.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is an exon-5-lacking transcript (PMIDs:15611072 and 18075264). It lacks an in-frame coding exon and has an additional 3 nts at an alternate splice site, as compared to variant 1. The resulting isoform (2) is shorter; it lacks an internal segment but has a downstream extra aa, as compared to isoform 1.
    Source sequence(s)
    BC056921, BQ771344, BY361646
    Consensus CDS
    CCDS17448.1
    UniProtKB/Swiss-Prot
    Q1EDG7, Q1EDG8, Q4H483, Q4W8V1, Q6PGN3, Q8BUU0, Q8BX25
    UniProtKB/TrEMBL
    A0A0A6YX71
    Related
    ENSMUSP00000029719.9, ENSMUST00000029719.14
    Conserved Domains (3) summary
    smart00220
    Location:393 → 650
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00537
    Location:67 → 157
    DCX; Domain in the Doublecortin (DCX) gene product
    cl21453
    Location:391 → 649
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    86693457..86828292 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252823.2 → XP_030108683.1  serine/threonine-protein kinase DCLK2 isoform X23

    UniProtKB/TrEMBL
    A0A0A6YWI6
    Related
    ENSMUSP00000141567.2, ENSMUST00000192773.6
    Conserved Domains (3) summary
    cd17069
    Location:192 → 275
    DCX2; Dublecortin-like domain 2
    cd17141
    Location:70 → 154
    DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
    cl21453
    Location:390 → 637
    PKc_like; Protein Kinases, catalytic domain

  2. XM_030252818.2 → XP_030108678.1  serine/threonine-protein kinase DCLK2 isoform X5

    UniProtKB/TrEMBL
    A0A0A6YX71
    Conserved Domains (3) summary
    cd17069
    Location:192 → 275
    DCX2; Dublecortin-like domain 2
    cd17141
    Location:70 → 154
    DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
    cl21453
    Location:390 → 638
    PKc_like; Protein Kinases, catalytic domain

  3. XM_030252821.2 → XP_030108681.1  serine/threonine-protein kinase DCLK2 isoform X18

    UniProtKB/TrEMBL
    A0A0A6YX71
    Conserved Domains (3) summary
    cd17069
    Location:192 → 275
    DCX2; Dublecortin-like domain 2
    cd17141
    Location:70 → 154
    DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
    cl21453
    Location:390 → 648
    PKc_like; Protein Kinases, catalytic domain

  4. XM_006502071.4 → XP_006502134.1  serine/threonine-protein kinase DCLK2 isoform X10

    UniProtKB/TrEMBL
    A0A0A6YX71
    Conserved Domains (3) summary
    cd17069
    Location:192 → 275
    DCX2; Dublecortin-like domain 2
    cd17141
    Location:70 → 154
    DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
    cl21453
    Location:390 → 648
    PKc_like; Protein Kinases, catalytic domain

  5. XM_030252822.2 → XP_030108682.1  serine/threonine-protein kinase DCLK2 isoform X22

    UniProtKB/TrEMBL
    A0A0A6YWI6
    Conserved Domains (3) summary
    cd17069
    Location:192 → 275
    DCX2; Dublecortin-like domain 2
    cd17141
    Location:70 → 154
    DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
    cl21453
    Location:391 → 638
    PKc_like; Protein Kinases, catalytic domain

  6. XM_006502067.4 → XP_006502130.1  serine/threonine-protein kinase DCLK2 isoform X4

    UniProtKB/TrEMBL
    A0A0A6YX71
    Conserved Domains (3) summary
    cd17069
    Location:192 → 275
    DCX2; Dublecortin-like domain 2
    cd17141
    Location:70 → 154
    DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
    cl21453
    Location:391 → 639
    PKc_like; Protein Kinases, catalytic domain

  7. XM_030252820.2 → XP_030108680.1  serine/threonine-protein kinase DCLK2 isoform X17

    UniProtKB/TrEMBL
    A0A0A6YX71
    Conserved Domains (3) summary
    cd17069
    Location:192 → 275
    DCX2; Dublecortin-like domain 2
    cd17141
    Location:70 → 154
    DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
    cl21453
    Location:391 → 649
    PKc_like; Protein Kinases, catalytic domain

  8. XM_030252819.2 → XP_030108679.1  serine/threonine-protein kinase DCLK2 isoform X9

    UniProtKB/TrEMBL
    A0A0A6YX71
    Conserved Domains (3) summary
    cd17069
    Location:192 → 275
    DCX2; Dublecortin-like domain 2
    cd17141
    Location:70 → 154
    DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
    cl21453
    Location:391 → 649
    PKc_like; Protein Kinases, catalytic domain

  9. XM_036163308.1 → XP_036019201.1  serine/threonine-protein kinase DCLK2 isoform X3

    UniProtKB/TrEMBL
    A0A0A6YX71
    Conserved Domains (3) summary
    cd17069
    Location:192 → 275
    DCX2; Dublecortin-like domain 2
    cd17141
    Location:70 → 154
    DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
    cl21453
    Location:406 → 654
    PKc_like; Protein Kinases, catalytic domain

  10. XM_036163309.1 → XP_036019202.1  serine/threonine-protein kinase DCLK2 isoform X13

    UniProtKB/TrEMBL
    A0A0A6YX71
    Conserved Domains (3) summary
    cd17069
    Location:192 → 275
    DCX2; Dublecortin-like domain 2
    cd17141
    Location:70 → 154
    DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
    cl21453
    Location:406 → 664
    PKc_like; Protein Kinases, catalytic domain

  11. XM_011240226.3 → XP_011238528.1  serine/threonine-protein kinase DCLK2 isoform X11

    UniProtKB/TrEMBL
    A0A0A6YWI6
    Conserved Domains (3) summary
    cd17069
    Location:192 → 275
    DCX2; Dublecortin-like domain 2
    cd17141
    Location:70 → 154
    DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
    cl21453
    Location:407 → 607
    PKc_like; Protein Kinases, catalytic domain

  12. XM_017319719.3 → XP_017175208.1  serine/threonine-protein kinase DCLK2 isoform X24

    UniProtKB/TrEMBL
    A0A0A6YWI6
    Conserved Domains (3) summary
    cd17069
    Location:192 → 275
    DCX2; Dublecortin-like domain 2
    cd17141
    Location:70 → 154
    DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
    cl21453
    Location:407 → 607
    PKc_like; Protein Kinases, catalytic domain

  13. XM_011240227.3 → XP_011238529.1  serine/threonine-protein kinase DCLK2 isoform X25

    UniProtKB/TrEMBL
    A0A0A6YWI6
    Conserved Domains (3) summary
    cd17069
    Location:192 → 275
    DCX2; Dublecortin-like domain 2
    cd17141
    Location:70 → 154
    DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
    cl21453
    Location:407 → 607
    PKc_like; Protein Kinases, catalytic domain

  14. XM_006502076.4 → XP_006502139.1  serine/threonine-protein kinase DCLK2 isoform X19

    UniProtKB/TrEMBL
    A0A0A6YWI6
    Conserved Domains (3) summary
    cd17069
    Location:192 → 275
    DCX2; Dublecortin-like domain 2
    cd17141
    Location:70 → 154
    DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
    cl21453
    Location:407 → 654
    PKc_like; Protein Kinases, catalytic domain

  15. XM_006502070.4 → XP_006502133.1  serine/threonine-protein kinase DCLK2 isoform X8

    UniProtKB/TrEMBL
    A0A0A6YWI6
    Conserved Domains (3) summary
    cd17069
    Location:192 → 275
    DCX2; Dublecortin-like domain 2
    cd17141
    Location:70 → 154
    DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
    cl21453
    Location:407 → 659
    PKc_like; Protein Kinases, catalytic domain

  16. XM_006502078.4 → XP_006502141.1  serine/threonine-protein kinase DCLK2 isoform X21

    UniProtKB/TrEMBL
    A0A0A6YWI6
    Conserved Domains (3) summary
    cd17069
    Location:192 → 275
    DCX2; Dublecortin-like domain 2
    cd17141
    Location:70 → 154
    DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
    cl21453
    Location:407 → 654
    PKc_like; Protein Kinases, catalytic domain

  17. XM_006502066.4 → XP_006502129.1  serine/threonine-protein kinase DCLK2 isoform X2

    UniProtKB/TrEMBL
    A0A0A6YX71
    Conserved Domains (3) summary
    cd17069
    Location:192 → 275
    DCX2; Dublecortin-like domain 2
    cd17141
    Location:70 → 154
    DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
    cl21453
    Location:407 → 655
    PKc_like; Protein Kinases, catalytic domain

  18. XM_006502074.4 → XP_006502137.1  serine/threonine-protein kinase DCLK2 isoform X15

    UniProtKB/TrEMBL
    A0A0A6YX71
    Related
    ENSMUSP00000141707.2, ENSMUST00000191752.6
    Conserved Domains (3) summary
    cd17069
    Location:192 → 275
    DCX2; Dublecortin-like domain 2
    cd17141
    Location:70 → 154
    DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
    cl21453
    Location:407 → 655
    PKc_like; Protein Kinases, catalytic domain

  19. XM_006502072.4 → XP_006502135.1  serine/threonine-protein kinase DCLK2 isoform X12

    UniProtKB/TrEMBL
    A0A0A6YX71
    Conserved Domains (3) summary
    cd17069
    Location:192 → 275
    DCX2; Dublecortin-like domain 2
    cd17141
    Location:70 → 154
    DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
    cl21453
    Location:407 → 665
    PKc_like; Protein Kinases, catalytic domain

  20. XM_006502068.4 → XP_006502131.1  serine/threonine-protein kinase DCLK2 isoform X6

    UniProtKB/TrEMBL
    A0A0A6YX71
    Conserved Domains (3) summary
    cd17069
    Location:192 → 275
    DCX2; Dublecortin-like domain 2
    cd17141
    Location:70 → 154
    DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
    cl21453
    Location:407 → 665
    PKc_like; Protein Kinases, catalytic domain

  21. XM_006502075.4 → XP_006502138.1  serine/threonine-protein kinase DCLK2 isoform X16

    UniProtKB/TrEMBL
    A0A0A6YX71
    Conserved Domains (3) summary
    cd17069
    Location:192 → 275
    DCX2; Dublecortin-like domain 2
    cd17141
    Location:70 → 154
    DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
    cl21453
    Location:407 → 665
    PKc_like; Protein Kinases, catalytic domain

  22. XM_006502069.4 → XP_006502132.1  serine/threonine-protein kinase DCLK2 isoform X7

    UniProtKB/TrEMBL
    A0A0A6YX71
    Conserved Domains (3) summary
    cd17069
    Location:192 → 275
    DCX2; Dublecortin-like domain 2
    cd17141
    Location:70 → 154
    DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
    cl21453
    Location:407 → 665
    PKc_like; Protein Kinases, catalytic domain

  23. XM_006502077.4 → XP_006502140.1  serine/threonine-protein kinase DCLK2 isoform X20

    UniProtKB/TrEMBL
    A0A0A6YWI6
    Conserved Domains (3) summary
    cd17069
    Location:192 → 275
    DCX2; Dublecortin-like domain 2
    cd17141
    Location:70 → 154
    DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
    cl21453
    Location:407 → 655
    PKc_like; Protein Kinases, catalytic domain

  24. XM_006502073.4 → XP_006502136.1  serine/threonine-protein kinase DCLK2 isoform X14

    UniProtKB/TrEMBL
    A0A0A6YX71
    Related
    ENSMUSP00000141866.2, ENSMUST00000193632.6
    Conserved Domains (3) summary
    cd17069
    Location:192 → 275
    DCX2; Dublecortin-like domain 2
    cd17141
    Location:70 → 154
    DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
    cl21453
    Location:407 → 665
    PKc_like; Protein Kinases, catalytic domain

  25. XM_036163307.1 → XP_036019200.1  serine/threonine-protein kinase DCLK2 isoform X1

    UniProtKB/TrEMBL
    A0A0A6YWI6
    Conserved Domains (3) summary
    cd17069
    Location:192 → 275
    DCX2; Dublecortin-like domain 2
    cd17141
    Location:70 → 154
    DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
    cl21453
    Location:390 → 648
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_003954386.2 RNA Sequence

  2. XR_003954385.2 RNA Sequence

  3. XR_003954383.2 RNA Sequence

  4. XR_004941394.1 RNA Sequence

  5. XR_004941393.1 RNA Sequence

  6. XR_003954382.2 RNA Sequence

  7. XR_867231.4 RNA Sequence

  8. XR_003954387.2 RNA Sequence

  9. XR_867229.3 RNA Sequence

  10. XR_003954384.2 RNA Sequence

  11. XR_004941392.1 RNA Sequence

  12. XR_003954381.2 RNA Sequence

  13. XR_001783745.3 RNA Sequence

  14. XR_004941391.1 RNA Sequence

  15. XR_004941390.1 RNA Sequence

  16. XR_867230.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PGN3.1 GenPept UniProtKB/Swiss-Prot:Q6PGN3

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