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Hacd2 3-hydroxyacyl-CoA dehydratase 2 [ Mus musculus (house mouse) ]

Gene ID: 70757, updated on 11-Apr-2024

Summary

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Official Symbol
Hacd2provided by MGI
Official Full Name
3-hydroxyacyl-CoA dehydratase 2provided by MGI
Primary source
MGI:MGI:1918007
See related
Ensembl:ENSMUSG00000035376 AllianceGenome:MGI:1918007
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hcad2; Ptplb; 6330408J20Rik
Summary
Predicted to enable 3-hydroxyacyl-CoA dehydratase activity; 3R-hydroxyacyl-CoA dehydratase activity; and enzyme binding activity. Predicted to be involved in fatty acid elongation; sphingolipid biosynthetic process; and very long-chain fatty acid biosynthetic process. Predicted to act upstream of or within fatty acid biosynthetic process. Predicted to be located in endoplasmic reticulum. Predicted to be integral component of endoplasmic reticulum membrane. Orthologous to human HACD2 (3-hydroxyacyl-CoA dehydratase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in genital fat pad adult (RPKM 24.6), subcutaneous fat pad adult (RPKM 18.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 B3; 16 24.54 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (34842791..34929560)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (35022421..35109190)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene myosin, light polypeptide kinase Neighboring gene RIKEN cDNA E130310I04 gene Neighboring gene STARR-seq mESC enhancer starr_40730 Neighboring gene STARR-seq mESC enhancer starr_40731 Neighboring gene STARR-positive B cell enhancer ABC_E1922 Neighboring gene predicted gene, 21691 Neighboring gene predicted gene, 53952 Neighboring gene STARR-seq mESC enhancer starr_40734 Neighboring gene adenylate cyclase 5 Neighboring gene STARR-seq mESC enhancer starr_40735 Neighboring gene predicted gene, 46550 Neighboring gene STARR-seq mESC enhancer starr_40736 Neighboring gene predicted gene, 25179 Neighboring gene STARR-seq mESC enhancer starr_40737 Neighboring gene SEC22 homolog A, vesicle trafficking protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular cloning, chromosomal mapping, and developmental expression of a novel protein tyrosine phosphatase-like gene. Uwanogho DA, et al. Genomics, 1999 Dec 15. PMID 10644438
  2. HACD1, a regulator of membrane composition and fluidity, promotes myoblast fusion and skeletal muscle growth. Blondelle J, et al. J Mol Cell Biol, 2015 Oct. PMID 26160855, Free PMC Article
  3. Hacd2 deficiency in mice leads to an early and lethal mitochondrial disease. Khadhraoui N, et al. Mol Metab, 2023 Mar. PMID 36693621, Free PMC Article
  4. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article
  5. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hacd2 deficiency in mice leads to an early and lethal mitochondrial disease.
    Title: Hacd2 deficiency in mice leads to an early and lethal mitochondrial disease.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (5)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3-hydroxyacyl-CoA dehydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3-hydroxyacyl-CoA dehydratase activity ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid elongation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in sphingolipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sphingolipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in very long-chain fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in very long-chain fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2
Names
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b
protein-tyrosine phosphatase-like member B
very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 2
NP_076076.2
XP_006522633.1
XP_006522634.1
XP_036016022.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023587.2 → NP_076076.2  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2

    See identical proteins and their annotated locations for NP_076076.2

    Status: VALIDATED

    Source sequence(s)
    AC154230, AK148143
    Consensus CDS
    CCDS37321.1
    UniProtKB/Swiss-Prot
    Q3UG38, Q9D3B1, Q9JLK1
    Related
    ENSMUSP00000060462.9, ENSMUST00000061156.10
    Conserved Domains (1) summary
    pfam04387
    Location:85 → 244
    PTPLA; Protein tyrosine phosphatase-like protein, PTPLA

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    34842791..34929560
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160129.1 → XP_036016022.1  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 isoform X1

    Conserved Domains (1) summary
    pfam04387
    Location:1 → 134
    PTPLA; Protein tyrosine phosphatase-like protein, PTPLA

  2. XM_006522570.4 → XP_006522633.1  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 isoform X1

    See identical proteins and their annotated locations for XP_006522633.1

    Conserved Domains (1) summary
    pfam04387
    Location:1 → 134
    PTPLA; Protein tyrosine phosphatase-like protein, PTPLA

  3. XM_006522571.1 → XP_006522634.1  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 isoform X1

    See identical proteins and their annotated locations for XP_006522634.1

    Conserved Domains (1) summary
    pfam04387
    Location:1 → 134
    PTPLA; Protein tyrosine phosphatase-like protein, PTPLA
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D3B1.1 GenPept UniProtKB/Swiss-Prot:Q9D3B1

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