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Tspan2 tetraspanin 2 [ Mus musculus (house mouse) ]

Gene ID: 70747, updated on 11-Apr-2024

Summary

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Official Symbol
Tspan2provided by MGI
Official Full Name
tetraspanin 2provided by MGI
Primary source
MGI:MGI:1917997
See related
Ensembl:ENSMUSG00000027858 AllianceGenome:MGI:1917997
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
tspan-2; 6330415F13Rik; B230119D02Rik
Summary
Acts upstream of or within inflammatory response and nervous system development. Located in myelin sheath and plasma membrane. Is expressed in pituitary gland. Orthologous to human TSPAN2 (tetraspanin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 25.4), cerebellum adult (RPKM 22.1) and 13 other tissues See more
Orthologs
human all
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Genomic context

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See Tspan2 in Genome Data Viewer
Location:
3 F2.2; 3 45.25 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (102642086..102679626)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (102734770..102772310)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_08577 Neighboring gene STARR-positive B cell enhancer ABC_E3456 Neighboring gene TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor pseudogene Neighboring gene predicted gene, 40112 Neighboring gene STARR-seq mESC enhancer starr_08578 Neighboring gene tetraspanin 2, opposite strand Neighboring gene STARR-seq mESC enhancer starr_08579 Neighboring gene STARR-positive B cell enhancer mm9_chr3:102608013-102608314 Neighboring gene thyroid stimulating hormone, beta subunit Neighboring gene synaptonemal complex protein 1 Neighboring gene STARR-seq mESC enhancer starr_08580 Neighboring gene predicted gene, 33866

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Uncoupling of neuroinflammation from axonal degeneration in mice lacking the myelin protein tetraspanin-2. de Monasterio-Schrader P, et al. Glia, 2013 Nov. PMID 24038504
  2. Convergent functional genomics of oligodendrocyte differentiation identifies multiple autoinhibitory signaling circuits. Gobert RP, et al. Mol Cell Biol, 2009 Mar. PMID 19139271, Free PMC Article
  3. Planar cell polarity defects and defective Vangl2 trafficking in mutants for the COPII gene Sec24b. Wansleeben C, et al. Development, 2010 Apr. PMID 20215345
  4. Appearance of new tetraspanin genes during vertebrate evolution. Garcia-España A, et al. Genomics, 2008 Apr. PMID 18291621
  5. Absence of canonical Smad signaling in ureteral and bladder mesenchyme causes ureteropelvic junction obstruction. Tripathi P, et al. J Am Soc Nephrol, 2012 Apr. PMID 22282597, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the activation of astrocytes and microglia was strongly enhanced in Tspan2(null) *Plp1(null) double-mutants compared with either single-mutant
    Title: Uncoupling of neuroinflammation from axonal degeneration in mice lacking the myelin protein tetraspanin-2.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within astrocyte development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within astrocyte development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within axon development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within inflammatory response IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within microglia development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within microglia development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within myelination IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within oligodendrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in myelin sheath IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tetraspanin-2
Names
tetraspan 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243132.1 → NP_001230061.1  tetraspanin-2 isoform 2

    See identical proteins and their annotated locations for NP_001230061.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate start codon, compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC134871, AK020982, AK160479
    Consensus CDS
    CCDS57249.1
    UniProtKB/TrEMBL
    Q8C0C9, Q9D1X8
    Related
    ENSMUSP00000113803.2, ENSMUST00000119902.6
    Conserved Domains (2) summary
    cd03151
    Location:106 → 182
    CD81_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD81_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:20 → 210
    Tetraspannin; Tetraspanin family

  2. NM_027533.3 → NP_081809.2  tetraspanin-2 isoform 1

    See identical proteins and their annotated locations for NP_081809.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC134871, AK018178, AK079560
    Consensus CDS
    CCDS17688.1
    UniProtKB/Swiss-Prot
    Q543K4, Q922J6, Q9D397
    UniProtKB/TrEMBL
    Q8C0C9
    Related
    ENSMUSP00000029451.6, ENSMUST00000029451.12
    Conserved Domains (2) summary
    cd03151
    Location:110 → 186
    CD81_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD81_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:10 → 214
    Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    102642086..102679626
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q922J6.1 GenPept UniProtKB/Swiss-Prot:Q922J6

Gene LinkOut

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