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Nup205 nucleoporin 205 [ Mus musculus (house mouse) ]

Gene ID: 70699, updated on 5-Mar-2024

Summary

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Official Symbol
Nup205provided by MGI
Official Full Name
nucleoporin 205provided by MGI
Primary source
MGI:MGI:2141625
See related
Ensembl:ENSMUSG00000038759 AllianceGenome:MGI:2141625
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0225; 3830404O05Rik
Summary
Predicted to be a structural constituent of nuclear pore. Predicted to be involved in nuclear pore complex assembly. Predicted to be located in nuclear membrane and nuclear periphery. Predicted to be part of nuclear pore inner ring. Human ortholog(s) of this gene implicated in nephrotic syndrome type 13. Orthologous to human NUP205 (nucleoporin 205). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 28.2), CNS E11.5 (RPKM 14.0) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 B1; 6 15.24 cM
Exon count:
48
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (35154551..35224534)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (35177616..35247599)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:34902551-34902660 Neighboring gene solute carrier family 23 member 4 Neighboring gene CCR4-NOT transcription complex, subunit 4 Neighboring gene STARR-seq mESC enhancer starr_15552 Neighboring gene STARR-positive B cell enhancer ABC_E2779 Neighboring gene predicted gene, 33046 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:35141265-35141448 Neighboring gene STARR-seq mESC enhancer starr_15553 Neighboring gene STARR-seq mESC enhancer starr_15554 Neighboring gene predicted gene, 23435 Neighboring gene STARR-seq mESC enhancer starr_15555 Neighboring gene short transmembrane mitochondrial protein 1 Neighboring gene solute carrier family 13 (sodium/sulfate symporters), member 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12 Intron Splicing-Defective Zrsr1 Mutant Mice. Horiuchi K, et al. Cell Rep, 2018 Apr 3. PMID 29617656
  2. Lack of periostin leads to suppression of Notch1 signaling and calcific aortic valve disease. Tkatchenko TV, et al. Physiol Genomics, 2009 Nov 6. PMID 19723774, Free PMC Article
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  4. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Sang L, et al. Cell, 2011 May 13. PMID 21565611, Free PMC Article
  5. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural constituent of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of nuclear pore ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in nuclear pore complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear pore organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear periphery ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear pore ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear pore inner ring IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
nuclear pore complex protein Nup205

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027513.1 → NP_081789.1  nuclear pore complex protein Nup205

    See identical proteins and their annotated locations for NP_081789.1

    Status: VALIDATED

    Source sequence(s)
    BC058729, BC060139, BY713599
    Consensus CDS
    CCDS57418.1
    UniProtKB/TrEMBL
    B9EJ54, Q6PDG0
    Related
    ENSMUSP00000039656.10, ENSMUST00000043815.16
    Conserved Domains (1) summary
    pfam11894
    Location:14 → 1684
    Nup192; Nuclear pore complex scaffold, nucleoporins 186/192/205

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    35154551..35224534
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506590.4 → XP_006506653.1  nuclear pore complex protein Nup205 isoform X1

    UniProtKB/TrEMBL
    Q6PDG0
    Conserved Domains (1) summary
    pfam11894
    Location:55 → 1725
    Nup192; Nuclear pore complex scaffold, nucleoporins 186/192/205

  2. XM_017321734.3 → XP_017177223.1  nuclear pore complex protein Nup205 isoform X2

    UniProtKB/TrEMBL
    Q6PDG0
    Conserved Domains (1) summary
    pfam11894
    Location:2 → 1644
    Nup192; Nuclear pore complex scaffold, nucleoporins 186/192/205

  3. XM_006506593.4 → XP_006506656.1  nuclear pore complex protein Nup205 isoform X4

    Related
    ENSMUST00000201609.4
    Conserved Domains (1) summary
    cl29134
    Location:1 → 879
    Nup192; Nuclear pore complex scaffold, nucleoporins 186/192/205

  4. XM_017321735.3 → XP_017177224.1  nuclear pore complex protein Nup205 isoform X3

    Conserved Domains (1) summary
    cl29134
    Location:16 → 945
    Nup192; Nuclear pore complex scaffold, nucleoporins 186/192/205

RNA

  1. XR_001785168.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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