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Zcchc8 zinc finger, CCHC domain containing 8 [ Mus musculus (house mouse) ]

Gene ID: 70650, updated on 5-Mar-2024

Summary

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Official Symbol
Zcchc8provided by MGI
Official Full Name
zinc finger, CCHC domain containing 8provided by MGI
Primary source
MGI:MGI:1917900
See related
Ensembl:ENSMUSG00000029427 AllianceGenome:MGI:1917900
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5730565F05Rik
Summary
Predicted to enable RNA binding activity. Predicted to be involved in ncRNA processing. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in nuclear body. Predicted to be part of TRAMP complex and catalytic step 2 spliceosome. Is expressed in several structures, including blastocyst; early embryo; eye; secondary oocyte; and trunk somite. Orthologous to human ZCCHC8 (zinc finger CCHC-type containing 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 18.9), testis adult (RPKM 13.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 F; 5 63.14 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (123836365..123859107, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (123698302..123721044, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr5:123993667-123993967 Neighboring gene VPS33A CORVET/HOPS core subunit Neighboring gene STARR-positive B cell enhancer ABC_E2176 Neighboring gene CAP-GLY domain containing linker protein 1 Neighboring gene STARR-seq mESC enhancer starr_14324 Neighboring gene predicted gene, 24840 Neighboring gene STARR-seq mESC enhancer starr_14325 Neighboring gene STARR-seq mESC enhancer starr_14326 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide K pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E104 Neighboring gene arginine/serine-rich coiled-coil 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Nuclear Exosome Targeting Complex Core Factor Zcchc8 Regulates the Degradation of LINE1 RNA in Early Embryos and Embryonic Stem Cells. Wu Y, et al. Cell Rep, 2019 Nov 19. PMID 31747613
  2. ZCCHC8, the nuclear exosome targeting component, is mutated in familial pulmonary fibrosis and is required for telomerase RNA maturation. Gable DL, et al. Genes Dev, 2019 Oct 1. PMID 31488579, Free PMC Article
  3. Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex. Kajimura S, et al. Nature, 2009 Aug 27. PMID 19641492, Free PMC Article
  4. The trafficking protein Tmed2/p24beta(1) is required for morphogenesis of the mouse embryo and placenta. Jerome-Majewska LA, et al. Dev Biol, 2010 May 1. PMID 20178780, Free PMC Article
  5. Elf5-centered transcription factor hub controls trophoblast stem cell self-renewal and differentiation through stoichiometry-sensitive shifts in target gene networks. Latos PA, et al. Genes Dev, 2015 Dec 1. PMID 26584622, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nuclear Exosome Targeting Complex Core Factor Zcchc8 Regulates the Degradation of LINE1 RNA in Early Embryos and Embryonic Stem Cells.
    Title: Nuclear Exosome Targeting Complex Core Factor Zcchc8 Regulates the Degradation of LINE1 RNA in Early Embryos and Embryonic Stem Cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in ncRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ncRNA processing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of TRAMP complex ISO
Inferred from Sequence Orthology
more info
  
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger CCHC domain-containing protein 8
Names
TRAMP-like complex RNA-binding factor ZCCHC8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027494.3 → NP_081770.3  zinc finger CCHC domain-containing protein 8

    See identical proteins and their annotated locations for NP_081770.3

    Status: VALIDATED

    Source sequence(s)
    AK043312, AK167126, BY090296
    Consensus CDS
    CCDS80406.1
    UniProtKB/Swiss-Prot
    Q3TK71, Q8CCB7, Q91WQ1, Q9CYA6
    UniProtKB/TrEMBL
    Q3TKH5
    Related
    ENSMUSP00000142363.2, ENSMUST00000196282.5
    Conserved Domains (2) summary
    pfam00098
    Location:230 → 247
    zf-CCHC; Zinc knuckle
    cl02643
    Location:286 → 338
    PSP; PSP

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    123836365..123859107 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530457.1 → XP_006530520.1  zinc finger CCHC domain-containing protein 8 isoform X1

    Conserved Domains (2) summary
    smart00343
    Location:44 → 58
    ZnF_C2HC; zinc finger
    cl02643
    Location:98 → 150
    PSP

  2. XM_011248240.4 → XP_011246542.1  zinc finger CCHC domain-containing protein 8 isoform X2

    Conserved Domains (2) summary
    smart00343
    Location:12 → 26
    ZnF_C2HC; zinc finger
    cl02643
    Location:66 → 118
    PSP
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CYA6.3 GenPept UniProtKB/Swiss-Prot:Q9CYA6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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