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Ube2v2 ubiquitin-conjugating enzyme E2 variant 2 [ Mus musculus (house mouse) ]

Gene ID: 70620, updated on 5-Mar-2024

Summary

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Official Symbol
Ube2v2provided by MGI
Official Full Name
ubiquitin-conjugating enzyme E2 variant 2provided by MGI
Primary source
MGI:MGI:1917870
See related
Ensembl:ENSMUSG00000022674 AllianceGenome:MGI:1917870
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MMS2; 6820402M05; 1110021H13Rik; 4632410D19Rik; 5730524P06Rik
Summary
Acts upstream of or within error-free postreplication DNA repair. Predicted to be located in nucleoplasm. Predicted to be part of UBC13-MMS2 complex. Predicted to be active in nucleus. Is expressed in embryo. Orthologous to human UBE2V2 (ubiquitin conjugating enzyme E2 V2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 12.0), CNS E14 (RPKM 9.0) and 17 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 A1- A2; 16 10.09 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (15368850..15412382, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (15550986..15594518, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40205 Neighboring gene predicted gene 7085 Neighboring gene STARR-seq mESC enhancer starr_40206 Neighboring gene predicted gene, 41424 Neighboring gene STARR-seq mESC enhancer starr_40207 Neighboring gene STARR-seq mESC enhancer starr_40208 Neighboring gene STARR-seq mESC enhancer starr_40209 Neighboring gene STARR-seq mESC enhancer starr_40211 Neighboring gene predicted gene 7748 Neighboring gene minichromosome maintenance complex component 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Angiotensin II type 2 receptor deletion enhances vascular senescence by methyl methanesulfonate sensitive 2 inhibition. Min LJ, et al. Hypertension, 2008 May. PMID 18362223
  2. Recurrent carcinoma of the rectum, surgical treatment. JACKSON BR, et al. Calif Med, 1959 Sep. PMID 14406273, Free PMC Article
  3. Molecular cloning and functional characterization of two murine cDNAs which encode Ubc variants involved in DNA repair and mutagenesis. Franko J, et al. Biochim Biophys Acta, 2001 May 28. PMID 11406273
  4. The tomato Fni3 lysine-63-specific ubiquitin-conjugating enzyme and suv ubiquitin E2 variant positively regulate plant immunity. Mural RV, et al. Plant Cell, 2013 Sep. PMID 24076975, Free PMC Article
  5. Roles of mouse UBC13 in DNA postreplication repair and Lys63-linked ubiquitination. Ashley C, et al. Gene, 2002 Feb 20. PMID 12039045

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC102399

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA double-strand break processing ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within error-free postreplication DNA repair IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of double-strand break repair ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein K63-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of synapse assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in postreplication repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K63-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of UBC13-MMS2 complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ubiquitin-conjugating enzyme E2 variant 2
Names
methyl methanesulfonate sensitive 2
ubc-like protein MMS2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159351.1 → NP_001152823.1  ubiquitin-conjugating enzyme E2 variant 2 isoform 2

    See identical proteins and their annotated locations for NP_001152823.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    BY025619, CJ049747, CT010522
    Consensus CDS
    CCDS49771.1
    UniProtKB/Swiss-Prot
    Q9D2M8
    Related
    ENSMUSP00000111442.2, ENSMUST00000115776.2
    Conserved Domains (1) summary
    cl00154
    Location:14 → 103
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  2. NM_023585.4 → NP_076074.2  ubiquitin-conjugating enzyme E2 variant 2 isoform 1

    See identical proteins and their annotated locations for NP_076074.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK028472, BY025619, CT010522
    Consensus CDS
    CCDS37265.1
    UniProtKB/Swiss-Prot
    A6X924, Q8BGH6, Q8CE99, Q8K2V7, Q9CYD7, Q9D2M8, Q9ERI8
    UniProtKB/TrEMBL
    Q4VBX4
    Related
    ENSMUSP00000111443.4, ENSMUST00000115777.10
    Conserved Domains (1) summary
    smart00212
    Location:14 → 145
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    15368850..15412382 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246011.2 → XP_011244313.1  ubiquitin-conjugating enzyme E2 variant 2 isoform X1

    See identical proteins and their annotated locations for XP_011244313.1

    UniProtKB/TrEMBL
    A6X925
    Related
    ENSMUSP00000093951.4, ENSMUST00000096234.4
    Conserved Domains (1) summary
    smart00212
    Location:2 → 105
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D2M8.4 GenPept UniProtKB/Swiss-Prot:Q9D2M8

Gene LinkOut

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