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Tmem230 transmembrane protein 230 [ Mus musculus (house mouse) ]

Gene ID: 70612, updated on 5-Mar-2024

Summary

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Official Symbol
Tmem230provided by MGI
Official Full Name
transmembrane protein 230provided by MGI
Primary source
MGI:MGI:1917862
See related
Ensembl:ENSMUSG00000027341 AllianceGenome:MGI:1917862
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5730494N06Rik
Summary
Predicted to be involved in synaptic vesicle transport. Predicted to be located in endoplasmic reticulum; endosome; and trans-Golgi network. Predicted to be active in synaptic vesicle. Orthologous to human TMEM230 (transmembrane protein 230). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 16.1), ovary adult (RPKM 16.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 F2; 2 64.15 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (132081412..132089708, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (132239492..132249059, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene solute carrier family 23 (nucleobase transporters), member 2 Neighboring gene STARR-positive B cell enhancer ABC_E8795 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_05728 Neighboring gene predicted gene 14051 Neighboring gene STARR-seq mESC enhancer starr_05733 Neighboring gene STARR-seq mESC enhancer starr_05734 Neighboring gene STARR-seq mESC enhancer starr_05736 Neighboring gene predicted gene, 29720 Neighboring gene STARR-positive B cell enhancer ABC_E10149 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:132079079-132079188 Neighboring gene expressed sequence AV099323 Neighboring gene proliferating cell nuclear antigen

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Phosphoproteomic analysis of the developing mouse brain. Ballif BA, et al. Mol Cell Proteomics, 2004 Nov. PMID 15345747
  2. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in synaptic vesicle transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic vesicle transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in late endosome ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transmembrane protein 230
Names
UPF0414 transmembrane protein C20orf30 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001141971.1 → NP_001135443.1  transmembrane protein 230

    See identical proteins and their annotated locations for NP_001135443.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    AK017729, BQ922165, BY278953, BY388388
    Consensus CDS
    CCDS16770.1
    UniProtKB/Swiss-Prot
    Q8CIB6, Q9CYF7
    Related
    ENSMUSP00000136826.2, ENSMUST00000180286.2
    Conserved Domains (1) summary
    pfam05915
    Location:44 → 118
    DUF872; Eukaryotic protein of unknown function (DUF872)

  2. NM_027478.3 → NP_081754.2  transmembrane protein 230

    See identical proteins and their annotated locations for NP_081754.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AK017729, BQ922165, BY278953, BY388388
    Consensus CDS
    CCDS16770.1
    UniProtKB/Swiss-Prot
    Q8CIB6, Q9CYF7
    Related
    ENSMUSP00000028816.3, ENSMUST00000028816.9
    Conserved Domains (1) summary
    pfam05915
    Location:44 → 118
    DUF872; Eukaryotic protein of unknown function (DUF872)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    132081412..132089708 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500166.5 → XP_006500229.1  transmembrane protein 230 isoform X1

    See identical proteins and their annotated locations for XP_006500229.1

    UniProtKB/Swiss-Prot
    Q8CIB6, Q9CYF7
    Related
    ENSMUSP00000105792.2, ENSMUST00000110163.8
    Conserved Domains (1) summary
    pfam05915
    Location:44 → 118
    DUF872; Eukaryotic protein of unknown function (DUF872)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CIB6.1 GenPept UniProtKB/Swiss-Prot:Q8CIB6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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