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Dnajb14 DnaJ heat shock protein family (Hsp40) member B14 [ Mus musculus (house mouse) ]

Gene ID: 70604, updated on 5-Mar-2024

Summary

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Official Symbol
Dnajb14provided by MGI
Official Full Name
DnaJ heat shock protein family (Hsp40) member B14provided by MGI
Primary source
MGI:MGI:1917854
See related
Ensembl:ENSMUSG00000074212 AllianceGenome:MGI:1917854
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5730496F10Rik
Summary
Predicted to enable Hsp70 protein binding activity. Predicted to be involved in several processes, including cellular response to misfolded protein; chaperone cofactor-dependent protein refolding; and ubiquitin-dependent ERAD pathway. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human DNAJB14 (DnaJ heat shock protein family (Hsp40) member B14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 8.5), cerebellum adult (RPKM 6.3) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 G3; 3 63.94 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (137572801..137619350)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (137867675..137916563)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:137527362-137527471 Neighboring gene STARR-positive B cell enhancer ABC_E4600 Neighboring gene predicted gene 43403 Neighboring gene STARR-seq mESC enhancer starr_09095 Neighboring gene H2A.Z variant histone 1 Neighboring gene predicted gene, 40155 Neighboring gene protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9081 Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 Neighboring gene dual adaptor for phosphotyrosine and 3-phosphoinositides 1 Neighboring gene STARR-positive B cell enhancer ABC_E9226 Neighboring gene predicted gene, 19708 Neighboring gene STARR-seq mESC enhancer starr_09102 Neighboring gene STARR-positive B cell enhancer ABC_E6138

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A novel mammalian ER-located J-protein, DNAJB14, can accelerate ERAD of misfolded membrane proteins. Sopha P, et al. Cell Struct Funct, 2012. PMID 23018488
  2. Tissue expression patterns identify mouse cilia genes. McClintock TS, et al. Physiol Genomics, 2008 Jan 17. PMID 17971504
  3. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Hsp70 protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Hsp70 protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to misfolded protein IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chaperone cofactor-dependent protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chaperone cofactor-dependent protein refolding ISO
Inferred from Sequence Orthology
more info
  
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dnaJ homolog subfamily B member 14
Names
DnaJ (Hsp40) homolog, subfamily B, member 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033155.1 → NP_001028327.1  dnaJ homolog subfamily B member 14

    See identical proteins and their annotated locations for NP_001028327.1

    Status: VALIDATED

    Source sequence(s)
    AC125154, AC146607
    Consensus CDS
    CCDS51077.1
    UniProtKB/Swiss-Prot
    Q149L6, Q3TU54, Q3UTE5
    Related
    ENSMUSP00000087641.6, ENSMUST00000090178.10
    Conserved Domains (3) summary
    COG0484
    Location:107 → 214
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam00226
    Location:108 → 169
    DnaJ; DnaJ domain
    pfam09320
    Location:271 → 371
    DUF1977; Domain of unknown function (DUF1977)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    137572801..137619350
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163304.1 → XP_036019197.1  dnaJ homolog subfamily B member 14 isoform X2

    Conserved Domains (1) summary
    COG0484
    Location:107 → 214
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

  2. XM_006502056.3 → XP_006502119.1  dnaJ homolog subfamily B member 14 isoform X3

    Conserved Domains (2) summary
    COG0484
    Location:40 → 147
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam09320
    Location:204 → 304
    DUF1977; Domain of unknown function (DUF1977)

  3. XM_006502055.3 → XP_006502118.1  dnaJ homolog subfamily B member 14 isoform X1

    UniProtKB/Swiss-Prot
    Q149L6
    Conserved Domains (2) summary
    COG0484
    Location:57 → 164
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam09320
    Location:221 → 321
    DUF1977; Domain of unknown function (DUF1977)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q149L6.1 GenPept UniProtKB/Swiss-Prot:Q149L6

Gene LinkOut

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