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Filip1 filamin A interacting protein 1 [ Mus musculus (house mouse) ]

Gene ID: 70598, updated on 5-Mar-2024

Summary

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Official Symbol
Filip1provided by MGI
Official Full Name
filamin A interacting protein 1provided by MGI
Primary source
MGI:MGI:1917848
See related
Ensembl:ENSMUSG00000034898 AllianceGenome:MGI:1917848
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5730485H21Rik
Summary
Involved in modification of postsynaptic structure. Located in glutamatergic synapse. Is expressed in adrenal gland and bladder wall. Orthologous to human FILIP1 (filamin A interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 7.9), heart adult (RPKM 6.6) and 19 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 E1; 9 43.83 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (79708461..79920135, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (79805018..80012851, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2297 Neighboring gene predicted gene, 51685 Neighboring gene RIKEN cDNA 4930429F24 gene Neighboring gene cytochrome c oxidase subunit 7A2 Neighboring gene STARR-positive B cell enhancer ABC_E5090 Neighboring gene transmembrane protein 30A Neighboring gene STARR-positive B cell enhancer ABC_E11416 Neighboring gene STARR-positive B cell enhancer ABC_E2298 Neighboring gene predicted gene, 35261 Neighboring gene predicted gene, 53505 Neighboring gene STARR-seq mESC enhancer starr_24749 Neighboring gene STARR-seq mESC enhancer starr_24751 Neighboring gene STARR-seq mESC enhancer starr_24752 Neighboring gene 5'-nucleotidase domain containing 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_24753 Neighboring gene STARR-seq mESC enhancer starr_24754 Neighboring gene STARR-positive B cell enhancer ABC_E715 Neighboring gene predicted gene, 46146 Neighboring gene STARR-positive B cell enhancer ABC_E8303 Neighboring gene SUMO/sentrin specific peptidase 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Filamin A interacting protein plays a role in proper positioning of callosal projection neurons in the cortex. Yagi H, et al. Neurosci Lett, 2016 Jan 26. PMID 26655467
  2. A novel long non-coding RNA Myolinc regulates myogenesis through TDP-43 and Filip1. Militello G, et al. J Mol Cell Biol, 2018 Apr 1. PMID 29618024, Free PMC Article
  3. Filamin A Is Required for Optimal T Cell Integrin-Mediated Force Transmission, Flow Adhesion, and T Cell Trafficking. Savinko T, et al. J Immunol, 2018 May 1. PMID 29581355
  4. Involvement of filamin A and filamin A-interacting protein (FILIP) in controlling the start and cell shape of radially migrating cortical neurons. Sato M, et al. Anat Sci Int, 2005 Mar. PMID 15794127
  5. Subcellular distribution of non-muscle myosin IIb is controlled by FILIP through Hsc70. Yagi H, et al. PLoS One, 2017. PMID 28234934, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Knockdown of a novel long non-coding RNA Myolinc impairs the expression of myogenic regulatory factors and formation of multi-nucleated myotubes in cultured myoblasts. Myolinc also regulates the expression of Filip1 in a cis-manner. Similar to Myolinc, knockdown of Filip1 inhibits myogenic differentiation.
    Title: A novel long non-coding RNA Myolinc regulates myogenesis through TDP-43 and Filip1.
  2. Our results reveal a role of FlnA in integrin force transmission and T cell trafficking
    Title: Filamin A Is Required for Optimal T Cell Integrin-Mediated Force Transmission, Flow Adhesion, and T Cell Trafficking.
  3. Hsc70 interacts with FILIP to mediate its effects on non-muscle myosin IIb and to regulate spine morphology
    Title: Subcellular distribution of non-muscle myosin IIb is controlled by FILIP through Hsc70.
  4. FILIP is a key molecule that links callosal projections to the pathogenesis of brain disorders.
    Title: Filamin A interacting protein plays a role in proper positioning of callosal projection neurons in the cortex.
  5. Results suggest that the amount of Filamin A helps migrating neurons determine their mode of migration, multipolar or bipolar, before entering the cortical plate and that FILIP is responsible, at least in part, for Filamin A content.
    Title: Filamin A and FILIP (Filamin A-Interacting Protein) regulate cell polarity and motility in neocortical subventricular and intermediate zones during radial migration.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in modification of postsynaptic structure IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in modification of postsynaptic structure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
filamin-A-interacting protein 1
Names
FILIP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081243.3 → NP_001074712.1  filamin-A-interacting protein 1 isoform b

    See identical proteins and their annotated locations for NP_001074712.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AC127318, AC140247
    Consensus CDS
    CCDS40704.1
    UniProtKB/Swiss-Prot
    Q059P4, Q9CS72
    Related
    ENSMUSP00000091329.5, ENSMUST00000093811.11
    Conserved Domains (3) summary
    PLN03209
    Location:955 → 1168
    PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
    pfam09727
    Location:74 → 255
    CortBP2; Cortactin-binding protein-2
    cl25732
    Location:205 → 738
    SMC_N; RecF/RecN/SMC N terminal domain

  2. NM_001357352.2 → NP_001344281.1  filamin-A-interacting protein 1 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC140247, AC142111
    Conserved Domains (3) summary
    PLN03209
    Location:970 → 1183
    PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
    pfam09727
    Location:89 → 270
    CortBP2; Cortactin-binding protein-2
    cl25732
    Location:220 → 753
    SMC_N; RecF/RecN/SMC N terminal domain

  3. NM_001357353.2 → NP_001344282.1  filamin-A-interacting protein 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AC127318, AC140247
    Consensus CDS
    CCDS40704.1
    UniProtKB/Swiss-Prot
    Q059P4, Q9CS72
    Conserved Domains (3) summary
    PLN03209
    Location:955 → 1168
    PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
    pfam09727
    Location:74 → 255
    CortBP2; Cortactin-binding protein-2
    cl25732
    Location:205 → 738
    SMC_N; RecF/RecN/SMC N terminal domain

  4. NM_001357354.1 → NP_001344283.1  filamin-A-interacting protein 1 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AC140247, CF727145, CF738763
    Related
    ENSMUST00000172740.2
    Conserved Domains (2) summary
    PLN03209
    Location:707 → 920
    PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
    PRK03918
    Location:3 → 498
    PRK03918; DNA double-strand break repair ATPase Rad50

  5. NM_001407987.1 → NP_001394916.1  filamin-A-interacting protein 1 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC127318, AC140247
    UniProtKB/TrEMBL
    A0A5F8MPD6
    Related
    ENSMUSP00000158921.2, ENSMUST00000239133.2

  6. NM_001407988.1 → NP_001394917.1  filamin-A-interacting protein 1 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC140247

  7. NM_001407989.1 → NP_001394918.1  filamin-A-interacting protein 1 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC140247

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    79708461..79920135 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CS72.3 GenPept UniProtKB/Swiss-Prot:Q9CS72

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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