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Cpne3 copine III [ Mus musculus (house mouse) ]

Gene ID: 70568, updated on 5-Mar-2024

Summary

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Official Symbol
Cpne3provided by MGI
Official Full Name
copine IIIprovided by MGI
Primary source
MGI:MGI:1917818
See related
Ensembl:ENSMUSG00000028228 AllianceGenome:MGI:1917818
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CPN3; 5430428M23Rik; 5730450C07Rik
Summary
Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encodes a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bladder adult (RPKM 13.3), kidney adult (RPKM 8.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 A3; 4 7.53 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (19519252..19570108, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (19519252..19570108, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12393 Neighboring gene cyclic nucleotide gated channel beta 3 Neighboring gene SET pseudogene Neighboring gene STARR-seq mESC enhancer starr_09695 Neighboring gene STARR-seq mESC enhancer starr_09696 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:19502117-19502304 Neighboring gene regulator of microtubule dynamics 1 Neighboring gene predicted gene, 52724 Neighboring gene WW domain containing E3 ubiquitin protein ligase 1 Neighboring gene predicted gene 12353

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The copines, a novel class of C2 domain-containing, calcium-dependent, phospholipid-binding proteins conserved from Paramecium to humans. Creutz CE, et al. J Biol Chem, 1998 Jan 16. PMID 9430674
  2. NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure. Eom T, et al. Elife, 2013 Jan 22. PMID 23359859, Free PMC Article
  3. Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles. Eisenhardt AE, et al. Oncotarget, 2016 May 3. PMID 27034005, Free PMC Article
  4. Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Lumayag S, et al. Proc Natl Acad Sci U S A, 2013 Feb 5. PMID 23341629, Free PMC Article
  5. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0636

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipid binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables receptor tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ERBB2 signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ERBB2 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to calcium ion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to calcium ion ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to growth factor stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
copine-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356481.1 → NP_001343410.1  copine-3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK017651, AL683894, BC090632, BQ033175
    Conserved Domains (1) summary
    pfam07002
    Location:78 → 295
    Copine; Copine

  2. NM_027769.3 → NP_082045.1  copine-3 isoform 1

    See identical proteins and their annotated locations for NP_082045.1

    Status: VALIDATED

    Source sequence(s)
    AK017651, BC090632, BQ033175
    Consensus CDS
    CCDS17991.1
    UniProtKB/Swiss-Prot
    Q5CZX9, Q5DU22, Q8BT60
    UniProtKB/TrEMBL
    Q3UJS6
    Related
    ENSMUSP00000029885.5, ENSMUST00000029885.5
    Conserved Domains (3) summary
    cd04047
    Location:139 → 251
    C2B_Copine; C2 domain second repeat in Copine
    cd04048
    Location:7 → 125
    C2A_Copine; C2 domain first repeat in Copine
    pfam07002
    Location:310 → 527
    Copine; Copine

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    19519252..19570108 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BT60.2 GenPept UniProtKB/Swiss-Prot:Q8BT60

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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