U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Txndc16 thioredoxin domain containing 16 [ Mus musculus (house mouse) ]

Gene ID: 70561, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Txndc16provided by MGI
Official Full Name
thioredoxin domain containing 16provided by MGI
Primary source
MGI:MGI:1917811
See related
Ensembl:ENSMUSG00000021830 AllianceGenome:MGI:1917811
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5730420B22Rik
Summary
Predicted to be located in endoplasmic reticulum lumen. Orthologous to human TXNDC16 (thioredoxin domain containing 16). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 6.5), frontal lobe adult (RPKM 6.5) and 24 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
14 22.77 cM; 14 C1
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (45371905..45457008, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (45134448..45219551, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene prostaglandin E receptor 2 (subtype EP2) Neighboring gene STARR-seq mESC enhancer starr_36533 Neighboring gene tubulin, alpha 1A pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7305 Neighboring gene predicted gene, 34362 Neighboring gene STARR-positive B cell enhancer ABC_E95 Neighboring gene tubulin, beta 6 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr14:45861577-45861878 Neighboring gene G protein-coupled receptor 137C Neighboring gene endoplasmic reticulum oxidoreductase 1 alpha

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum lumen ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
thioredoxin domain-containing protein 16

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310534.1 → NP_001297463.1  thioredoxin domain-containing protein 16 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001297463.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK046466, BY122029, CX209472
    Consensus CDS
    CCDS79300.1
    UniProtKB/Swiss-Prot
    Q69ZL5, Q7TN22, Q8BL40, Q8R2W8, Q9CS82
    Related
    ENSMUSP00000120287.2, ENSMUST00000139526.9
    Conserved Domains (3) summary
    cd02961
    Location:395 → 493
    PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...
    TIGR01130
    Location:65 → 493
    ER_PDI_fam; protein disulfide isomerase, eukaryotic
    pfam13848
    Location:534 → 722
    Thioredoxin_6; Thioredoxin-like domain

  2. NM_172597.3 → NP_766185.1  thioredoxin domain-containing protein 16 isoform 2 precursor

    See identical proteins and their annotated locations for NP_766185.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice donor site in the 3' coding region, compared to variant 1. It encodes isoform 2 which is one amino acid shorter than isoform 1.
    Source sequence(s)
    AK046466, BY122029
    Consensus CDS
    CCDS26973.1
    UniProtKB/Swiss-Prot
    Q7TN22
    Related
    ENSMUSP00000022377.5, ENSMUST00000022377.11
    Conserved Domains (3) summary
    cd02961
    Location:395 → 493
    PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...
    TIGR01130
    Location:65 → 493
    ER_PDI_fam; protein disulfide isomerase, eukaryotic
    pfam13848
    Location:534 → 722
    Thioredoxin_6; Thioredoxin-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    45371905..45457008 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017316187.3 → XP_017171676.1  thioredoxin domain-containing protein 16 isoform X10

    Conserved Domains (2) summary
    cd02961
    Location:164 → 262
    PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...
    TIGR01130
    Location:164 → 375
    ER_PDI_fam; protein disulfide isomerase, eukaryotic

  2. XM_006519520.5 → XP_006519583.1  thioredoxin domain-containing protein 16 isoform X1

    See identical proteins and their annotated locations for XP_006519583.1

    UniProtKB/Swiss-Prot
    Q69ZL5, Q7TN22, Q8BL40, Q8R2W8, Q9CS82
    Related
    ENSMUSP00000123023.2, ENSMUST00000123879.8
    Conserved Domains (3) summary
    cd02961
    Location:395 → 493
    PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...
    TIGR01130
    Location:65 → 493
    ER_PDI_fam; protein disulfide isomerase, eukaryotic
    pfam13848
    Location:534 → 722
    Thioredoxin_6; Thioredoxin-like domain

  3. XM_030248016.2 → XP_030103876.1  thioredoxin domain-containing protein 16 isoform X9

    Conserved Domains (2) summary
    cd02961
    Location:164 → 262
    PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...
    pfam13848
    Location:303 → 491
    Thioredoxin_6; Thioredoxin-like domain

  4. XM_030248014.1 → XP_030103874.1  thioredoxin domain-containing protein 16 isoform X4

    Conserved Domains (2) summary
    cd02961
    Location:395 → 493
    PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...
    TIGR01130
    Location:395 → 594
    ER_PDI_fam; protein disulfide isomerase, eukaryotic

  5. XM_011245182.3 → XP_011243484.1  thioredoxin domain-containing protein 16 isoform X3

    Conserved Domains (2) summary
    cd02961
    Location:395 → 493
    PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...
    TIGR01130
    Location:395 → 594
    ER_PDI_fam; protein disulfide isomerase, eukaryotic

  6. XM_011245184.3 → XP_011243486.1  thioredoxin domain-containing protein 16 isoform X6

    Conserved Domains (2) summary
    cd02961
    Location:395 → 493
    PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...
    TIGR01130
    Location:395 → 606
    ER_PDI_fam; protein disulfide isomerase, eukaryotic

  7. XM_011245183.3 → XP_011243485.1  thioredoxin domain-containing protein 16 isoform X5

    Conserved Domains (2) summary
    cd02961
    Location:395 → 493
    PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...
    TIGR01130
    Location:395 → 606
    ER_PDI_fam; protein disulfide isomerase, eukaryotic

  8. XM_036158846.1 → XP_036014739.1  thioredoxin domain-containing protein 16 isoform X2

    Conserved Domains (3) summary
    cd02961
    Location:395 → 493
    PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...
    TIGR01130
    Location:65 → 493
    ER_PDI_fam; protein disulfide isomerase, eukaryotic
    pfam13848
    Location:534 → 722
    Thioredoxin_6; Thioredoxin-like domain

  9. XM_011245180.3 → XP_011243482.1  thioredoxin domain-containing protein 16 isoform X1

    See identical proteins and their annotated locations for XP_011243482.1

    UniProtKB/Swiss-Prot
    Q69ZL5, Q7TN22, Q8BL40, Q8R2W8, Q9CS82
    Conserved Domains (3) summary
    cd02961
    Location:395 → 493
    PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...
    TIGR01130
    Location:65 → 493
    ER_PDI_fam; protein disulfide isomerase, eukaryotic
    pfam13848
    Location:534 → 722
    Thioredoxin_6; Thioredoxin-like domain

  10. XM_017316186.2 → XP_017171675.1  thioredoxin domain-containing protein 16 isoform X1

    UniProtKB/Swiss-Prot
    Q69ZL5, Q7TN22, Q8BL40, Q8R2W8, Q9CS82
    Conserved Domains (3) summary
    cd02961
    Location:395 → 493
    PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...
    TIGR01130
    Location:65 → 493
    ER_PDI_fam; protein disulfide isomerase, eukaryotic
    pfam13848
    Location:534 → 722
    Thioredoxin_6; Thioredoxin-like domain

  11. XM_030248015.2 → XP_030103875.1  thioredoxin domain-containing protein 16 isoform X5

    Conserved Domains (2) summary
    cd02961
    Location:395 → 493
    PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...
    TIGR01130
    Location:395 → 606
    ER_PDI_fam; protein disulfide isomerase, eukaryotic

  12. XM_030248013.2 → XP_030103873.1  thioredoxin domain-containing protein 16 isoform X2

    Conserved Domains (3) summary
    cd02961
    Location:395 → 493
    PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...
    TIGR01130
    Location:65 → 493
    ER_PDI_fam; protein disulfide isomerase, eukaryotic
    pfam13848
    Location:534 → 722
    Thioredoxin_6; Thioredoxin-like domain

  13. XM_011245185.4 → XP_011243487.1  thioredoxin domain-containing protein 16 isoform X7

    Conserved Domains (2) summary
    cd02961
    Location:235 → 333
    PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...
    pfam13848
    Location:374 → 562
    Thioredoxin_6; Thioredoxin-like domain

  14. XM_006519527.5 → XP_006519590.1  thioredoxin domain-containing protein 16 isoform X8

    Conserved Domains (2) summary
    cd02961
    Location:218 → 316
    PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...
    pfam13848
    Location:357 → 545
    Thioredoxin_6; Thioredoxin-like domain

RNA

  1. XR_004938444.1 RNA Sequence

  2. XR_001781157.2 RNA Sequence

  3. XR_001781156.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TN22.1 GenPept UniProtKB/Swiss-Prot:Q7TN22

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous