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Wars2 tryptophanyl tRNA synthetase 2 (mitochondrial) [ Mus musculus (house mouse) ]

Gene ID: 70560, updated on 5-Mar-2024

Summary

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Official Symbol
Wars2provided by MGI
Official Full Name
tryptophanyl tRNA synthetase 2 (mitochondrial)provided by MGI
Primary source
MGI:MGI:1917810
See related
Ensembl:ENSMUSG00000004233 AllianceGenome:MGI:1917810
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TrpRS; 5730427B17Rik; 9430020O07Rik
Summary
Predicted to enable tryptophan-tRNA ligase activity. Acts upstream of or within vasculogenesis. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; ear; genitourinary system; and skeleton. Orthologous to human WARS2 (tryptophanyl tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 1.9), CNS E11.5 (RPKM 1.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 F2.2; 3 43.03 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (99047423..99128546)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (99140107..99221230)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40105 Neighboring gene predicted gene, 22341 Neighboring gene predicted gene, 24216 Neighboring gene STARR-positive B cell enhancer ABC_E2089 Neighboring gene STARR-seq mESC enhancer starr_08484 Neighboring gene S-adenosylmethionine decarboxylase, pseudogene 3 pseudogene Neighboring gene microRNA 6481 Neighboring gene predicted gene, 38468 Neighboring gene predicted gene, 46817 Neighboring gene T-box 15

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A Wars2 mutant mouse shows a sex and diet specific change in fat distribution, reduced food intake and depot-specific upregulation of WAT browning. Mušo M, et al. Front Physiol, 2022. PMID 36091365, Free PMC Article
  2. A Wars2 Mutant Mouse Model Displays OXPHOS Deficiencies and Activation of Tissue-Specific Stress Response Pathways. Agnew T, et al. Cell Rep, 2018 Dec 18. PMID 30566859, Free PMC Article
  3. T2-TrpRS inhibits preretinal neovascularization and enhances physiological vascular regrowth in OIR as assessed by a new method of quantification. Banin E, et al. Invest Ophthalmol Vis Sci, 2006 May. PMID 16639024
  4. Species-specific differences in the regulation of the aminoacylation activity of mammalian tryptophanyl-tRNA synthetases. Wakasugi K. FEBS Lett, 2010 Jan 4. PMID 19941862
  5. Novel gene function revealed by mouse mutagenesis screens for models of age-related disease. Potter PK, et al. Nat Commun, 2016 Aug 18. PMID 27534441, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Chemically induced (ENU) (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables tryptophan-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tryptophan-tRNA ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in mitochondrial tryptophanyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
involved_in tryptophanyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within vasculogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tryptophan--tRNA ligase, mitochondrial
Names
(Mt)TrpRS
tryptophanyl-tRNA synthetase, mitochondrial
NP_001405926.1
NP_081738.2
XP_006502116.1
XP_017175206.1
XP_030108675.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418997.1 → NP_001405926.1  tryptophan--tRNA ligase, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC080018

  2. NM_027462.5 → NP_081738.2  tryptophan--tRNA ligase, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_081738.2

    Status: VALIDATED

    Source sequence(s)
    AC080018
    Consensus CDS
    CCDS17672.1
    UniProtKB/Swiss-Prot
    Q8BFV8, Q9CYK1
    Related
    ENSMUSP00000004343.3, ENSMUST00000004343.7
    Conserved Domains (2) summary
    cd00806
    Location:36 → 312
    TrpRS_core; catalytic core domain of tryptophanyl-tRNA synthetase
    PRK00927
    Location:35 → 360
    PRK00927; tryptophanyl-tRNA synthetase; Reviewed

RNA

  1. NR_185000.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC080018

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    99047423..99128546
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502053.5 → XP_006502116.1  tryptophan--tRNA ligase, mitochondrial isoform X4

    UniProtKB/TrEMBL
    A0A0G2JDR5
    Conserved Domains (1) summary
    PRK00927
    Location:58 → 195
    PRK00927; tryptophanyl-tRNA synthetase; Reviewed

  2. XM_017319717.3 → XP_017175206.1  tryptophan--tRNA ligase, mitochondrial isoform X1

    Conserved Domains (1) summary
    PRK00927
    Location:58 → 235
    PRK00927; tryptophanyl-tRNA synthetase; Reviewed

  3. XM_030252815.1 → XP_030108675.1  tryptophan--tRNA ligase, mitochondrial isoform X3

    Conserved Domains (1) summary
    PRK00927
    Location:1 → 231
    PRK00927; tryptophanyl-tRNA synthetase; Reviewed

RNA

  1. XR_001783742.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CYK1.2 GenPept UniProtKB/Swiss-Prot:Q9CYK1

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