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Slc25a33 solute carrier family 25, member 33 [ Mus musculus (house mouse) ]

Gene ID: 70556, updated on 5-Mar-2024

Summary

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Official Symbol
Slc25a33provided by MGI
Official Full Name
solute carrier family 25, member 33provided by MGI
Primary source
MGI:MGI:1917806
See related
Ensembl:ENSMUSG00000028982 AllianceGenome:MGI:1917806
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pnc1; 5730438N18Rik
Summary
Predicted to enable pyrimidine nucleotide transmembrane transporter activity. Involved in mitochondria-nucleus signaling pathway; positive regulation of cell growth; and pyrimidine nucleotide import into mitochondrion. Located in mitochondrial membrane. Is expressed in brainstem; liver; nervous system; and retina outer nuclear layer. Orthologous to human SLC25A33 (solute carrier family 25 member 33). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 23.3), cerebellum adult (RPKM 18.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 E2; 4 80.15 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (149828493..149858746, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (149744036..149774267, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:149032165-149032348 Neighboring gene phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Neighboring gene microRNA 7023 Neighboring gene STARR-positive B cell enhancer mm9_chr4:149063846-149064146 Neighboring gene STARR-positive B cell enhancer ABC_E9249 Neighboring gene STARR-positive B cell enhancer ABC_E2730 Neighboring gene STARR-positive B cell enhancer mm9_chr4:149084694-149084994 Neighboring gene transmembrane protein 201 Neighboring gene STARR-seq mESC enhancer starr_12124 Neighboring gene predicted gene 13073 Neighboring gene STARR-seq mESC enhancer starr_12127 Neighboring gene predicted gene, 42354

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The insulin-like growth factor-I-mTOR signaling pathway induces the mitochondrial pyrimidine nucleotide carrier to promote cell growth. Floyd S, et al. Mol Biol Cell, 2007 Sep. PMID 17596519, Free PMC Article
  2. Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant. Quinlan MA, et al. Front Mol Neurosci, 2020. PMID 32581705, Free PMC Article
  3. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
  4. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
  5. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The data indicate that PNC1 is a target of the IGF-I/mTOR pathway that is essential for mitochondrial activity in regulating cell growth and proliferation.
    Title: The insulin-like growth factor-I-mTOR signaling pathway induces the mitochondrial pyrimidine nucleotide carrier to promote cell growth.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC4399

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables pyrimidine nucleotide transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyrimidine nucleotide transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to insulin-like growth factor stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondria-nucleus signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitochondrial genome maintenance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial genome maintenance ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial respiratory chain complex III assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrion organization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell growth IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in pyrimidine nucleotide import into mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pyrimidine nucleotide import into mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pyrimidine nucleotide import into mitochondrion ISO
Inferred from Sequence Orthology
more info
  
involved_in pyrimidine nucleotide transport ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitochondrial membrane potential ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of oxidative phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of reactive oxygen species biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
solute carrier family 25 member 33
Names
mitochondrial carrier protein
novel mitochondrial carrier protein domains containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027460.2 → NP_081736.2  solute carrier family 25 member 33

    See identical proteins and their annotated locations for NP_081736.2

    Status: VALIDATED

    Source sequence(s)
    AW989568, BB772382, BG063566, BQ950692, CK795124
    Consensus CDS
    CCDS38976.1
    UniProtKB/Swiss-Prot
    Q3TZX3, Q921P8, Q9CYJ1
    Related
    ENSMUSP00000101311.3, ENSMUST00000105686.3
    Conserved Domains (2) summary
    PTZ00169
    Location:6 → 316
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:7 → 123
    Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    149828493..149858746 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164415.1 → XP_036020308.1  solute carrier family 25 member 33 isoform X2

    Conserved Domains (1) summary
    pfam00153
    Location:62 → 149
    Mito_carr; Mitochondrial carrier protein

  2. XM_036164414.1 → XP_036020307.1  solute carrier family 25 member 33 isoform X1

    Conserved Domains (1) summary
    pfam00153
    Location:65 → 152
    Mito_carr; Mitochondrial carrier protein

  3. XM_036164416.1 → XP_036020309.1  solute carrier family 25 member 33 isoform X2

    Conserved Domains (1) summary
    pfam00153
    Location:62 → 149
    Mito_carr; Mitochondrial carrier protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TZX3.1 GenPept UniProtKB/Swiss-Prot:Q3TZX3

Gene LinkOut

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