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Rprd1b regulation of nuclear pre-mRNA domain containing 1B [ Mus musculus (house mouse) ]

Gene ID: 70470, updated on 5-Mar-2024

Summary

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Official Symbol
Rprd1bprovided by MGI
Official Full Name
regulation of nuclear pre-mRNA domain containing 1Bprovided by MGI
Primary source
MGI:MGI:1917720
See related
Ensembl:ENSMUSG00000027651 AllianceGenome:MGI:1917720
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Crept; 2610304G08Rik; 2810446G03Rik
Summary
Predicted to enable RNA polymerase II complex binding activity and identical protein binding activity. Predicted to be involved in several processes, including mRNA 3'-end processing; positive regulation of cell population proliferation; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be part of RNA polymerase II, holoenzyme. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and mammary gland. Orthologous to human RPRD1B (regulation of nuclear pre-mRNA domain containing 1B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 11.4), limb E14.5 (RPKM 10.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 H1; 2 78.72 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (157870395..157920127)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (158028475..158078207)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 34402 Neighboring gene TELO2 interacting protein 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:157854071-157854293 Neighboring gene mediator of cell motility 1 pseudogene Neighboring gene RIKEN cDNA 2010009K17 gene Neighboring gene STARR-seq mESC enhancer starr_06227 Neighboring gene STARR-seq mESC enhancer starr_06228 Neighboring gene predicted gene, 34458 Neighboring gene transglutaminase 2, C polypeptide

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Establishment of a tamoxifen-inducible Cre-driver mouse strain for widespread and temporal genetic modification in adult mice. Ichise H, et al. Exp Anim, 2016 Jul 29. PMID 26923756, Free PMC Article
  2. The Kub5-Hera/RPRD1B interactome: a novel role in preserving genetic stability by regulating DNA mismatch repair. Patidar PL, et al. Nucleic Acids Res, 2016 Feb 29. PMID 26819409, Free PMC Article
  3. CREPT is required for murine stem cell maintenance during intestinal regeneration. Yang L, et al. Nat Commun, 2021 Jan 11. PMID 33431892, Free PMC Article
  4. Crosstalk between RNA Pol II C-Terminal Domain Acetylation and Phosphorylation via RPRD Proteins. Ali I, et al. Mol Cell, 2019 Jun 20. PMID 31054975, Free PMC Article
  5. CREPT regulated by miR-138 promotes breast cancer progression. Liang Z, et al. Biochem Biophys Res Commun, 2017 Nov 4. PMID 28893536

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Crosstalk between RNA Pol II C-terminal domain acetylation and phosphorylation via RPRD1B protein and its isoforms has been reported.
    Title: Crosstalk between RNA Pol II C-Terminal Domain Acetylation and Phosphorylation via RPRD Proteins.
  2. Mechanistically, CREPT regulated beta-catenin/TCF4/cyclin D1 pathway in BC. In conclusion, the data suggested that miR-138/CREPT involved BC progression, providing potential therapeutic targets for BC.
    Title: CREPT regulated by miR-138 promotes breast cancer progression.
  3. study suggests that CREPT acts as an activator to promote transcriptional activity of the beta-catenin.TCF4 complex in response to Wnt signaling.
    Title: CREPT/RPRD1B, a recently identified novel protein highly expressed in tumors, enhances the β-catenin·TCF4 transcriptional activity in response to Wnt signaling.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase II C-terminal domain binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II complex binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in RNA polymerase II promoter clearance ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription preinitiation complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
regulation of nuclear pre-mRNA domain-containing protein 1B
Names
cell cycle-related and expression-elevated protein in tumor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291134.1 → NP_001278063.1  regulation of nuclear pre-mRNA domain-containing protein 1B isoform a

    See identical proteins and their annotated locations for NP_001278063.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AI843346, AK011979, AK013301, AK035806, AK045404, AK147930
    Consensus CDS
    CCDS71177.1
    UniProtKB/Swiss-Prot
    A2ACF2, A2ACF4, A2ACF5, A2ACF6, Q1WDE6, Q3U8H1, Q3UGH1, Q3USX3, Q6GTJ6, Q9CSU0
    Related
    ENSMUSP00000029180.8, ENSMUST00000029180.14
    Conserved Domains (2) summary
    cd17012
    Location:3 → 131
    CID_RPRD1B; CID (CTD-Interacting Domain) of Regulation of nuclear pre-mRNA domain-containing protein 1B
    pfam16566
    Location:178 → 324
    CREPT; Cell-cycle alteration and expression-elevated protein in tumor

  2. NM_001291135.1 → NP_001278064.1  regulation of nuclear pre-mRNA domain-containing protein 1B isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an additional exon in the 3' region, and it thus differs in its 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (c) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AI843346, AK011979, AK013301, AK147930, AK152125, BP753919
    Consensus CDS
    CCDS71176.1
    UniProtKB/Swiss-Prot
    Q9CSU0
    Related
    ENSMUSP00000105144.2, ENSMUST00000109518.8
    Conserved Domains (2) summary
    smart00582
    Location:8 → 126
    RPR; domain present in proteins, which are involved in regulation of nuclear pre-mRNA
    pfam16566
    Location:178 → 284
    CREPT; Cell-cycle alteration and expression-elevated protein in tumour

  3. NM_001291136.1 → NP_001278065.1  regulation of nuclear pre-mRNA domain-containing protein 1B isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon in the 5' region, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, and it also uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (d) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AI843346, AK011979, AK013301, AK045404, AK147930, BP753919
    UniProtKB/Swiss-Prot
    Q9CSU0
    Related
    ENSMUST00000156552.8
    Conserved Domains (1) summary
    pfam16566
    Location:49 → 194
    CREPT; Cell-cycle alteration and expression-elevated protein in tumor

  4. NM_027434.3 → NP_081710.1  regulation of nuclear pre-mRNA domain-containing protein 1B isoform b

    See identical proteins and their annotated locations for NP_081710.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AI843346, AK011979, AK013301, AK045404, AK147930, BP753919
    Consensus CDS
    CCDS16984.1
    UniProtKB/TrEMBL
    A0A0R4J195
    Related
    ENSMUSP00000099412.4, ENSMUST00000103123.10
    Conserved Domains (2) summary
    cd17012
    Location:3 → 131
    CID_RPRD1B; CID (CTD-Interacting Domain) of Regulation of nuclear pre-mRNA domain-containing protein 1B
    pfam16566
    Location:177 → 323
    CREPT; Cell-cycle alteration and expression-elevated protein in tumor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    157870395..157920127
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500163.2 → XP_006500226.1  regulation of nuclear pre-mRNA domain-containing protein 1B isoform X2

    Related
    ENSMUSP00000118434.2, ENSMUST00000152452.8
    Conserved Domains (2) summary
    cd17012
    Location:3 → 131
    CID_RPRD1B; CID (CTD-Interacting Domain) of Regulation of nuclear pre-mRNA domain-containing protein 1B
    pfam16566
    Location:178 → 218
    CREPT; Cell-cycle alteration and expression-elevated protein in tumor

  2. XM_011239773.3 → XP_011238075.1  regulation of nuclear pre-mRNA domain-containing protein 1B isoform X4

    Conserved Domains (1) summary
    pfam16566
    Location:50 → 196
    CREPT; Cell-cycle alteration and expression-elevated protein in tumor

  3. XM_006500162.3 → XP_006500225.1  regulation of nuclear pre-mRNA domain-containing protein 1B isoform X1

    Conserved Domains (2) summary
    cd17012
    Location:3 → 131
    CID_RPRD1B; CID (CTD-Interacting Domain) of Regulation of nuclear pre-mRNA domain-containing protein 1B
    pfam16566
    Location:177 → 283
    CREPT; Cell-cycle alteration and expression-elevated protein in tumor

  4. XM_030252069.2 → XP_030107929.1  regulation of nuclear pre-mRNA domain-containing protein 1B isoform X3

    Conserved Domains (2) summary
    cd17012
    Location:3 → 131
    CID_RPRD1B; CID (CTD-Interacting Domain) of Regulation of nuclear pre-mRNA domain-containing protein 1B
    pfam16566
    Location:177 → 217
    CREPT; Cell-cycle alteration and expression-elevated protein in tumor

RNA

  1. XR_004940727.1 RNA Sequence

  2. XR_004940728.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CSU0.2 GenPept UniProtKB/Swiss-Prot:Q9CSU0

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