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Taf15 TATA-box binding protein associated factor 15 [ Mus musculus (house mouse) ]

Gene ID: 70439, updated on 5-Mar-2024

Summary

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Official Symbol
Taf15provided by MGI
Official Full Name
TATA-box binding protein associated factor 15provided by MGI
Primary source
MGI:MGI:1917689
See related
Ensembl:ENSMUSG00000020680 AllianceGenome:MGI:1917689
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
68kDa; Taf2n; TAFII68; 2610111C21Rik
Summary
Enables mRNA 3'-UTR binding activity. Acts upstream of or within RNA splicing. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; hemolymphoid system gland; pancreas epithelium; sensory organ; and urinary system. Human ortholog(s) of this gene implicated in chondrosarcoma and extraskeletal myxoid chondrosarcoma. Orthologous to human TAF15 (TATA-box binding protein associated factor 15). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 81.2), CNS E14 (RPKM 33.7) and 12 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 C; 11 50.49 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (83363897..83397569)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (83473073..83506743)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene growth arrest-specific 2 like 2 Neighboring gene RIKEN cDNA 1700020L24 gene Neighboring gene matrix metallopeptidase 28 (epilysin) Neighboring gene STARR-positive B cell enhancer ABC_E1836 Neighboring gene STARR-seq mESC enhancer starr_30202 Neighboring gene STARR-seq mESC enhancer starr_30203 Neighboring gene predicted gene, 32650 Neighboring gene HEAT repeat containing 9 Neighboring gene predicted gene, 23247 Neighboring gene C-C motif chemokine ligand 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of in vivo, conserved, TAF15 RNA binding sites reveals the impact of TAF15 on the neuronal transcriptome. Ibrahim F, et al. Cell Rep, 2013 Feb 21. PMID 23416048, Free PMC Article
  2. miR-182-5p inhibits the pathogenic Th17 response in experimental autoimmune uveitis mice via suppressing TAF15. Zhang L, et al. Biochem Biophys Res Commun, 2020 Aug 27. PMID 32736708
  3. Characterization of a new brain-specific isoform of the EWS oncoprotein. Melot T, et al. Eur J Biochem, 2001 Jun. PMID 11422378
  4. Post-transcriptional regulation of FUS and EWS protein expression by miR-141 during neural differentiation. Svetoni F, et al. Hum Mol Genet, 2017 Jul 15. PMID 28453628
  5. The hnRNP RALY regulates PRMT1 expression and interacts with the ALS-linked protein FUS: implication for reciprocal cellular localization. Gasperini L, et al. Mol Biol Cell, 2018 Dec 15. PMID 30354839, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TAF15 exacerbates nonalcoholic steatohepatitis progression by regulating lipid metabolism and inflammation via FASN and p65 NF-kappaB.
    Title: TAF15 exacerbates nonalcoholic steatohepatitis progression by regulating lipid metabolism and inflammation via FASN and p65 NF-κB.
  2. miR-182-5p inhibits the pathogenic Th17 response in experimental autoimmune uveitis mice via suppressing TAF15.
    Title: miR-182-5p inhibits the pathogenic Th17 response in experimental autoimmune uveitis mice via suppressing TAF15.
  3. FUS and TAF15 exhibit similar global RNA interaction profiles in vivo, but affect a strikingly small subset of common genes. Unexpectedly, TAF15 influences a small fraction of amyotrophic lateral sclerosis events compared with TDP-43 and FUS in the mouse CNS.
    Title: Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses.
  4. TAF15 is required for a critical alternative splicing event of the zeta-1 subunit of the glutamate N-methyl-D-aspartate receptor (Grin1) that controls the activity and trafficking of NR1.
    Title: Identification of in vivo, conserved, TAF15 RNA binding sites reveals the impact of TAF15 on the neuronal transcriptome.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within gene expression IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mRNA stabilization ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
TATA-binding protein-associated factor 2N
Names
TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68 kDa
TATA box binding protein (TBP)-associated factor, RNA polymerase II, N, 68kD (RNA binding protein 56)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027427.3 → NP_081703.1  TATA-binding protein-associated factor 2N

    See identical proteins and their annotated locations for NP_081703.1

    Status: VALIDATED

    Source sequence(s)
    AK051568, AL596122
    Consensus CDS
    CCDS25168.1
    UniProtKB/TrEMBL
    Q8BQ46
    Related
    ENSMUSP00000021018.5, ENSMUST00000021018.11
    Conserved Domains (4) summary
    COG0724
    Location:221 → 317
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12535
    Location:230 → 315
    RRM_FUS_TAF15; RNA recognition motif in vertebrate fused in Ewing's sarcoma protein (FUS), TATA-binding protein-associated factor 15 (TAF15) and similar proteins
    sd00029
    Location:356 → 377
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:352 → 382
    zf-RanBP; Zn-finger in Ran binding protein and others

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    83363897..83397569
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246301.2 → XP_030102161.1  TATA-binding protein-associated factor 2N isoform X1

    Conserved Domains (5) summary
    PTZ00110
    Location:4 → 69
    PTZ00110; helicase; Provisional
    cd12535
    Location:197 → 282
    RRM_FUS_TAF15; RNA recognition motif in vertebrate fused in Ewing's sarcoma protein (FUS), TATA-binding protein-associated factor 15 (TAF15) and similar proteins
    TIGR01622
    Location:106 → 280
    SF-CC1; splicing factor, CC1-like family
    sd00029
    Location:323 → 344
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:320 → 349
    zf-RanBP; Zn-finger in Ran binding protein and others

  2. XM_030246302.2 → XP_030102162.1  TATA-binding protein-associated factor 2N isoform X2

    Conserved Domains (5) summary
    PTZ00110
    Location:4 → 69
    PTZ00110; helicase; Provisional
    cd12535
    Location:178 → 263
    RRM_FUS_TAF15; RNA recognition motif in vertebrate fused in Ewing's sarcoma protein (FUS), TATA-binding protein-associated factor 15 (TAF15) and similar proteins
    sd00029
    Location:304 → 325
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:301 → 330
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam12273
    Location:102 → 153
    RCR; Chitin synthesis regulation, resistance to Congo red

  3. XM_030246304.1 → XP_030102164.1  TATA-binding protein-associated factor 2N isoform X3

    UniProtKB/TrEMBL
    F6QCI0
    Related
    ENSMUSP00000119836.2, ENSMUST00000133170.2
    Conserved Domains (3) summary
    cd12535
    Location:35 → 120
    RRM_FUS_TAF15; RNA recognition motif in vertebrate fused in Ewing's sarcoma protein (FUS), TATA-binding protein-associated factor 15 (TAF15) and similar proteins
    sd00029
    Location:161 → 182
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:158 → 187
    zf-RanBP; Zn-finger in Ran binding protein and others

  4. XM_030246305.2 → XP_030102165.1  TATA-binding protein-associated factor 2N isoform X4

    Conserved Domains (3) summary
    sd00025
    Location:89 → 110
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:85 → 115
    zf-RanBP; Zn-finger in Ran binding protein and others
    cl17169
    Location:1 → 48
    RRM_SF; RNA recognition motif (RRM) superfamily

  5. XM_036156982.1 → XP_036012875.1  TATA-binding protein-associated factor 2N isoform X4

    Conserved Domains (3) summary
    sd00025
    Location:89 → 110
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:85 → 115
    zf-RanBP; Zn-finger in Ran binding protein and others
    cl17169
    Location:1 → 48
    RRM_SF; RNA recognition motif (RRM) superfamily

  6. XM_036156984.1 → XP_036012877.1  TATA-binding protein-associated factor 2N isoform X4

    Conserved Domains (3) summary
    sd00025
    Location:89 → 110
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:85 → 115
    zf-RanBP; Zn-finger in Ran binding protein and others
    cl17169
    Location:1 → 48
    RRM_SF; RNA recognition motif (RRM) superfamily

  7. XM_036156983.1 → XP_036012876.1  TATA-binding protein-associated factor 2N isoform X4

    Conserved Domains (3) summary
    sd00025
    Location:89 → 110
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:85 → 115
    zf-RanBP; Zn-finger in Ran binding protein and others
    cl17169
    Location:1 → 48
    RRM_SF; RNA recognition motif (RRM) superfamily
Nucleotide Protein Strain
Heading Accession and Version

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