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Mier2 MIER family member 2 [ Mus musculus (house mouse) ]

Gene ID: 70427, updated on 5-Mar-2024

Summary

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Official Symbol
Mier2provided by MGI
Official Full Name
MIER family member 2provided by MGI
Primary source
MGI:MGI:1917677
See related
Ensembl:ENSMUSG00000042570 AllianceGenome:MGI:1917677
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mi-er2; mKIAA1193; 2700087H15Rik
Summary
Predicted to enable histone deacetylase binding activity and transcription corepressor activity. Predicted to contribute to histone deacetylase activity. Predicted to be involved in histone deacetylation and negative regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in nucleoplasm. Is expressed in early conceptus; inner cell mass; and oocyte. Orthologous to human MIER2 (MIER family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 17.7), adrenal adult (RPKM 16.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Mier2 in Genome Data Viewer
Location:
10 C1; 10 39.72 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (79376079..79395229, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (79540245..79557042, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene vomeronasal 2, receptor 83 Neighboring gene STARR-seq mESC enhancer starr_27246 Neighboring gene STARR-seq mESC enhancer starr_27247 Neighboring gene phospholipid phosphatase 2 Neighboring gene microRNA 6909 Neighboring gene sperm microtubule associated protein 2 Neighboring gene predicted gene, 51808 Neighboring gene C2 calcium-dependent domain containing 4C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Functional Proteomic Analysis of Repressive Histone Methyltransferase Complexes Reveals ZNF518B as a G9A Regulator. Maier VK, et al. Mol Cell Proteomics, 2015 Jun. PMID 25680957, Free PMC Article
  2. Functional consequences of necdin nucleocytoplasmic localization. Lavi-Itzkovitz A, et al. PLoS One, 2012. PMID 22442722, Free PMC Article
  3. Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. Nakahara M, et al. Mamm Genome, 2013 Jun. PMID 23604909
  4. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
  5. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to histone deacetylase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone deacetylase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mesoderm induction early response protein 2
Names
mesoderm induction early response 1, family member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316699.2 → NP_001303628.1  mesoderm induction early response protein 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC100708
    Consensus CDS
    CCDS83723.1
    UniProtKB/Swiss-Prot
    Q3U3N0, Q5XJI0, Q66JU5, Q69ZP0, Q6NXL7
    Related
    ENSMUSP00000127387.2, ENSMUST00000165028.8
    Conserved Domains (3) summary
    smart00717
    Location:300 → 346
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11661
    Location:301 → 345
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:196 → 246
    ELM2; ELM2 domain

  2. NM_027422.4 → NP_081698.2  mesoderm induction early response protein 2 isoform 2

    See identical proteins and their annotated locations for NP_081698.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 2 aa shorter compared to isoform 1.
    Source sequence(s)
    AC100708
    Consensus CDS
    CCDS48619.1
    UniProtKB/Swiss-Prot
    Q3U3N0
    Related
    ENSMUSP00000059864.9, ENSMUST00000062855.15
    Conserved Domains (3) summary
    smart00717
    Location:298 → 344
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11661
    Location:299 → 343
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:194 → 244
    ELM2; ELM2 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    79376079..79395229 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514083.4 → XP_006514146.1  mesoderm induction early response protein 2 isoform X3

    See identical proteins and their annotated locations for XP_006514146.1

    Conserved Domains (2) summary
    cd11661
    Location:301 → 345
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:196 → 246
    ELM2; ELM2 domain

  2. XM_036155999.1 → XP_036011892.1  mesoderm induction early response protein 2 isoform X7

    Conserved Domains (2) summary
    cd11661
    Location:105 → 149
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:1 → 50
    ELM2; ELM2 domain

  3. XM_036155995.1 → XP_036011888.1  mesoderm induction early response protein 2 isoform X5

    Conserved Domains (2) summary
    cd11661
    Location:265 → 309
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:160 → 210
    ELM2; ELM2 domain

  4. XM_006514086.1 → XP_006514149.1  mesoderm induction early response protein 2 isoform X4

    See identical proteins and their annotated locations for XP_006514149.1

    Conserved Domains (2) summary
    cd11661
    Location:265 → 309
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:160 → 210
    ELM2; ELM2 domain

  5. XM_036156000.1 → XP_036011893.1  mesoderm induction early response protein 2 isoform X7

    Conserved Domains (2) summary
    cd11661
    Location:105 → 149
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:1 → 50
    ELM2; ELM2 domain

  6. XM_006514082.2 → XP_006514145.1  mesoderm induction early response protein 2 isoform X2

    Conserved Domains (2) summary
    cd11661
    Location:314 → 358
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:209 → 259
    ELM2; ELM2 domain

  7. XM_006514081.1 → XP_006514144.1  mesoderm induction early response protein 2 isoform X1

    Conserved Domains (2) summary
    cd11661
    Location:314 → 358
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:209 → 259
    ELM2; ELM2 domain

  8. XM_036155997.1 → XP_036011890.1  mesoderm induction early response protein 2 isoform X7

    Conserved Domains (2) summary
    cd11661
    Location:105 → 149
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:1 → 50
    ELM2; ELM2 domain

  9. XM_036155996.1 → XP_036011889.1  mesoderm induction early response protein 2 isoform X6

    Conserved Domains (2) summary
    cd11661
    Location:105 → 149
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:1 → 50
    ELM2; ELM2 domain

  10. XM_030245264.2 → XP_030101124.1  mesoderm induction early response protein 2 isoform X5

    Conserved Domains (2) summary
    cd11661
    Location:265 → 309
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:160 → 210
    ELM2; ELM2 domain

  11. XM_017314086.3 → XP_017169575.1  mesoderm induction early response protein 2 isoform X4

    Conserved Domains (2) summary
    cd11661
    Location:265 → 309
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:160 → 210
    ELM2; ELM2 domain

  12. XM_030245265.2 → XP_030101125.1  mesoderm induction early response protein 2 isoform X5

    Conserved Domains (2) summary
    cd11661
    Location:265 → 309
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:160 → 210
    ELM2; ELM2 domain

  13. XM_006514085.2 → XP_006514148.1  mesoderm induction early response protein 2 isoform X4

    See identical proteins and their annotated locations for XP_006514148.1

    Conserved Domains (2) summary
    cd11661
    Location:265 → 309
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:160 → 210
    ELM2; ELM2 domain

  14. XM_030245263.1 → XP_030101123.1  mesoderm induction early response protein 2 isoform X4

    Conserved Domains (2) summary
    cd11661
    Location:265 → 309
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:160 → 210
    ELM2; ELM2 domain

  15. XM_036155998.1 → XP_036011891.1  mesoderm induction early response protein 2 isoform X7

    Conserved Domains (2) summary
    cd11661
    Location:105 → 149
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:1 → 50
    ELM2; ELM2 domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3U3N0.1 GenPept UniProtKB/Swiss-Prot:Q3U3N0

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