U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Csnk1g3 casein kinase 1, gamma 3 [ Mus musculus (house mouse) ]

Gene ID: 70425, updated on 21-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Csnk1g3provided by MGI
Official Full Name
casein kinase 1, gamma 3provided by MGI
Primary source
MGI:MGI:1917675
See related
Ensembl:ENSMUSG00000073563 AllianceGenome:MGI:1917675
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
3300002K07Rik; C330049O21Rik
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including Wnt signaling pathway; positive regulation of canonical Wnt signaling pathway; and protein phosphorylation. Predicted to act upstream of or within phosphorylation. Predicted to be active in cytoplasm; nucleus; and plasma membrane. Is expressed in central nervous system; jaw bone; and retina. Orthologous to human CSNK1G3 (casein kinase 1 gamma 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 12.9), CNS E14 (RPKM 11.5) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
18 D1- D2; 18 29.1 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (53995154..54088756)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (53862082..53955684)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 19466 Neighboring gene STARR-seq mESC enhancer starr_44626 Neighboring gene centrosomal protein 120 Neighboring gene STARR-positive B cell enhancer ABC_E966 Neighboring gene STARR-positive B cell enhancer ABC_E8978 Neighboring gene STARR-seq mESC enhancer starr_44627 Neighboring gene STARR-positive B cell enhancer ABC_E9449 Neighboring gene STARR-positive B cell enhancer mm9_chr18:54037188-54037489 Neighboring gene predicted gene, 41728 Neighboring gene STARR-positive B cell enhancer ABC_E5659 Neighboring gene STARR-positive B cell enhancer ABC_E1516 Neighboring gene STARR-seq mESC enhancer starr_44629 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene high mobility group box 2 pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Casein kinase-1γ1 and 3 stimulate tumor necrosis factor-induced necroptosis through RIPK3. Lee SY, et al. Cell Death Dis, 2019 Dec 4. PMID 31801942, Free PMC Article
  2. Genetic imbalances in preleukemic thymuses. Verlaet M, et al. Biochem Biophys Res Commun, 2001 Apr 27. PMID 11322760
  3. Hopx and Hdac2 interact to modulate Gata4 acetylation and embryonic cardiac myocyte proliferation. Trivedi CM, et al. Dev Cell, 2010 Sep 14. PMID 20833366, Free PMC Article
  4. Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST. Nakano Y, et al. Cell Rep, 2019 Apr 16. PMID 30995482, Free PMC Article
  5. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Casein kinase-1gamma1 and 3 stimulate tumor necrosis factor-induced necroptosis through RIPK3.
    Title: Casein kinase-1γ1 and 3 stimulate tumor necrosis factor-induced necroptosis through RIPK3.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 
  • Endonuclease-mediated (4) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
casein kinase I isoform gamma-3; casein kinase I
Names
CKI-gamma 3
NP_690022.2
XP_006526293.1
XP_006526294.1
XP_006526295.1
XP_006526296.1
XP_006526297.1
XP_006526298.1
XP_006526299.1
XP_006526300.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152809.2 → NP_690022.2  casein kinase I isoform gamma-3

    See identical proteins and their annotated locations for NP_690022.2

    Status: VALIDATED

    Source sequence(s)
    AK032675, AK034842, AK049379, AK163441, BQ443928, BY729947, CN454971
    Consensus CDS
    CCDS37823.1
    UniProtKB/Swiss-Prot
    Q8BM57, Q8C001, Q8C4X2, Q8K079
    Related
    ENSMUSP00000070259.7, ENSMUST00000069597.8
    Conserved Domains (2) summary
    cd14126
    Location:42 → 329
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:329 → 386
    CK1gamma_C; Casein kinase 1 gamma C terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    53995154..54088756
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526230.2 → XP_006526293.1  casein kinase I isoform X1

    See identical proteins and their annotated locations for XP_006526293.1

    Conserved Domains (2) summary
    cd14126
    Location:42 → 329
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:329 → 418
    CK1gamma_C; Casein kinase 1 gamma C terminal

  2. XM_006526233.2 → XP_006526296.1  casein kinase I isoform X4

    See identical proteins and their annotated locations for XP_006526296.1

    UniProtKB/TrEMBL
    A0A494BAP2
    Related
    ENSMUSP00000158175.2, ENSMUST00000237880.2
    Conserved Domains (2) summary
    cd14126
    Location:42 → 329
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:329 → 418
    CK1gamma_C; Casein kinase 1 gamma C terminal

  3. XM_006526232.2 → XP_006526295.1  casein kinase I isoform X3

    Conserved Domains (2) summary
    cd14126
    Location:42 → 329
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:329 → 416
    CK1gamma_C; Casein kinase 1 gamma C terminal

  4. XM_006526236.1 → XP_006526299.1  casein kinase I isoform X7

    See identical proteins and their annotated locations for XP_006526299.1

    Conserved Domains (2) summary
    cd14126
    Location:42 → 329
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:329 → 386
    CK1gamma_C; Casein kinase 1 gamma C terminal

  5. XM_006526231.2 → XP_006526294.1  casein kinase I isoform X2

    Conserved Domains (2) summary
    cd14126
    Location:42 → 328
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:328 → 417
    CK1gamma_C; Casein kinase 1 gamma C terminal

  6. XM_006526234.2 → XP_006526297.1  casein kinase I isoform X5

    Conserved Domains (2) summary
    cd14126
    Location:42 → 328
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:328 → 417
    CK1gamma_C; Casein kinase 1 gamma C terminal

  7. XM_006526235.1 → XP_006526298.1  casein kinase I isoform X6

    Conserved Domains (2) summary
    cd14126
    Location:42 → 328
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:328 → 385
    CK1gamma_C; Casein kinase 1 gamma C terminal

  8. XM_006526237.1 → XP_006526300.1  casein kinase I isoform X8

    Conserved Domains (2) summary
    cd14126
    Location:42 → 328
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:328 → 385
    CK1gamma_C; Casein kinase 1 gamma C terminal
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C4X2.2 GenPept UniProtKB/Swiss-Prot:Q8C4X2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous