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Tspan15 tetraspanin 15 [ Mus musculus (house mouse) ]

Gene ID: 70423, updated on 18-Apr-2024

Summary

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Official Symbol
Tspan15provided by MGI
Official Full Name
tetraspanin 15provided by MGI
Primary source
MGI:MGI:1917673
See related
Ensembl:ENSMUSG00000037031 AllianceGenome:MGI:1917673
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tm4sf15; 1110036D12Rik; 2700063A19Rik
Summary
Enables enzyme binding activity. Involved in protein maturation. Located in cell surface and tetraspanin-enriched microdomain. Is expressed in hypothalamus ventricular layer and pancreas epithelium. Orthologous to human TSPAN15 (tetraspanin 15). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in stomach adult (RPKM 37.0), duodenum adult (RPKM 31.3) and 19 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 B4; 10 32.36 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (62021175..62067055, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (62185396..62231276, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 241, member B Neighboring gene STARR-seq mESC enhancer starr_26874 Neighboring gene neurogenin 3 Neighboring gene STARR-positive B cell enhancer mm9_chr10:61645889-61646190 Neighboring gene microRNA 7662 Neighboring gene STARR-seq mESC enhancer starr_26875 Neighboring gene tachykinin receptor 2 Neighboring gene hexokinase 1 Neighboring gene STARR-seq mESC enhancer starr_26881 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:61802071-61802272 Neighboring gene STARR-positive B cell enhancer ABC_E9791 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:61803279-61803470 Neighboring gene hexokinase 1, opposite strand

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. In vivo regulation of the A disintegrin and metalloproteinase 10 (ADAM10) by the tetraspanin 15. Seipold L, et al. Cell Mol Life Sci, 2018 Sep. PMID 29520422
  2. The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex. Koo CZ, et al. J Biol Chem, 2020 Sep 4. PMID 32111735, Free PMC Article
  3. The TspanC8 subgroup of tetraspanins interacts with A disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expression. Haining EJ, et al. J Biol Chem, 2012 Nov 16. PMID 23035126, Free PMC Article
  4. A Dock-and-Lock Mechanism Clusters ADAM10 at Cell-Cell Junctions to Promote α-Toxin Cytotoxicity. Shah J, et al. Cell Rep, 2018 Nov 20. PMID 30463011
  5. Appearance of new tetraspanin genes during vertebrate evolution. Garcia-España A, et al. Genomics, 2008 Apr. PMID 18291621

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex.
    Title: The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex.
  2. Data show that tetraspanin15 (Tspan15) is abundantly expressed in brain, where it specifically interacts with endogenous a disintegrin and metalloproteinase 10 (ADAM10).
    Title: In vivo regulation of the A disintegrin and metalloproteinase 10 (ADAM10) by the tetraspanin 15.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2)  1 citation
  • Gene trapped (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in protein maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein maturation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of membrane protein ectodomain proteolysis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in tetraspanin-enriched microdomain IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tetraspanin-15
Names
transmembrane 4 superfamily member 15
tspan-15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_197996.2 → NP_932113.2  tetraspanin-15

    See identical proteins and their annotated locations for NP_932113.2

    Status: VALIDATED

    Source sequence(s)
    AC127417, CN455615, CX206586
    Consensus CDS
    CCDS56705.1
    UniProtKB/Swiss-Prot
    C0H5X1, F7BWT7, Q3TA07
    Related
    ENSMUSP00000047029.10, ENSMUST00000047883.11
    Conserved Domains (2) summary
    cd03158
    Location:114 → 231
    penumbra_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:19 → 256
    Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    62021175..62067055 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514080.1 → XP_006514143.1  tetraspanin-15 isoform X2

    Conserved Domains (1) summary
    cd03158
    Location:42 → 159
    penumbra_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

  2. XM_011243561.3 → XP_011241863.1  tetraspanin-15 isoform X3

    Conserved Domains (1) summary
    cd03158
    Location:18 → 133
    penumbra_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

  3. XM_011243560.4 → XP_011241862.1  tetraspanin-15 isoform X1

    Conserved Domains (2) summary
    cd03158
    Location:114 → 209
    penumbra_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:20 → 192
    Tetraspannin; Tetraspanin family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F7BWT7.2 GenPept UniProtKB/Swiss-Prot:F7BWT7

Gene LinkOut

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