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Tecpr1 tectonin beta-propeller repeat containing 1 [ Mus musculus (house mouse) ]

Gene ID: 70381, updated on 5-Mar-2024

Summary

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Official Symbol
Tecpr1provided by MGI
Official Full Name
tectonin beta-propeller repeat containing 1provided by MGI
Primary source
MGI:MGI:1917631
See related
Ensembl:ENSMUSG00000066621 AllianceGenome:MGI:1917631
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1358; 2210010N04Rik
Summary
Predicted to enable phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in autophagosome maturation. Predicted to be located in nucleoplasm. Predicted to be active in autophagosome membrane and lysosomal membrane. Is expressed in several structures, including alimentary system; brain; cochlea; ganglia; and vibrissa follicle. Orthologous to human TECPR1 (tectonin beta-propeller repeat containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 45.0), thymus adult (RPKM 42.1) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 G2; 5 83.07 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (144131260..144160433, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (144194442..144223615, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene lemur tyrosine kinase 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:144923715-144923898 Neighboring gene basic helix-loop-helix family, member a15 Neighboring gene STARR-positive B cell enhancer ABC_E2183 Neighboring gene RIKEN cDNA 2900089D17 gene Neighboring gene brain protein I3 Neighboring gene BAI1-associated protein 2-like 1 Neighboring gene predicted gene 15708

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A Tecpr1-dependent selective autophagy pathway targets bacterial pathogens. Ogawa M, et al. Cell Host Microbe, 2011 May 19. PMID 21575909
  2. Insights into autophagosome maturation revealed by the structures of ATG5 with its interacting partners. Kim JH, et al. Autophagy, 2015. PMID 25484072, Free PMC Article
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2002 Oct 31. PMID 12465718
  4. Regulatory pathway analysis by high-throughput in situ hybridization. Visel A, et al. PLoS Genet, 2007 Oct. PMID 17953485, Free PMC Article
  5. Insights into specificity, redundancy and new cellular functions of C/EBPa and C/EBPb transcription factors through interactome network analysis. Cirilli M, et al. Biochim Biophys Acta Gen Subj, 2017 Feb. PMID 27746211

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3-phosphate binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in autophagosome maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagosome maturation ISO
Inferred from Sequence Orthology
more info
  
involved_in autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in macroautophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of autophagosome maturation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in autophagosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in autophagosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
tectonin beta-propeller repeat-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356992.1 → NP_001343921.1  tectonin beta-propeller repeat-containing protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC139636
    Conserved Domains (5) summary
    smart00694
    Location:369 → 402
    DysFC; Dysferlin domain, C-terminal region
    smart00693
    Location:297 → 358
    DysFN; Dysferlin domain, N-terminal region
    smart00706
    Location:242 → 275
    TECPR; Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins
    cd13300
    Location:85 → 205
    PH1_TECPR1; Tectonin beta-propeller repeat-containing protein 1 Pleckstrin homology (PH) domain, repeat 1
    pfam19193
    Location:431 → 573
    Tectonin; Tectonin domain

  2. NM_001356993.1 → NP_001343922.1  tectonin beta-propeller repeat-containing protein 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses two alternate splice junctions compared to variant 1. The resulting isoform (3) is shorter at the N-terminus and lacks an internal segment compared to isoform 1.
    Source sequence(s)
    AC139636
    Conserved Domains (5) summary
    smart00694
    Location:364 → 397
    DysFC; Dysferlin domain, C-terminal region
    smart00693
    Location:292 → 353
    DysFN; Dysferlin domain, N-terminal region
    smart00706
    Location:545 → 570
    TECPR; Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins
    cd13300
    Location:80 → 200
    PH1_TECPR1; Tectonin beta-propeller repeat-containing protein 1 Pleckstrin homology (PH) domain, repeat 1
    pfam06462
    Location:522 → 550
    Hyd_WA; Propeller

  3. NM_027410.2 → NP_081686.1  tectonin beta-propeller repeat-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_081686.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC139636, AK040462, AW048569, BC046968
    Consensus CDS
    CCDS39377.1
    UniProtKB/Swiss-Prot
    Q80VP0, Q8CHA3, Q8R3E0, Q99KQ5, Q9CVC6
    Related
    ENSMUSP00000082844.7, ENSMUST00000085701.7
    Conserved Domains (6) summary
    smart00694
    Location:893 → 926
    DysFC; Dysferlin domain, C-terminal region
    smart00693
    Location:64 → 125
    DysFN; Dysferlin domain, N-terminal region
    smart00706
    Location:234 → 270
    TECPR; Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins
    cd13300
    Location:609 → 729
    PH1_TECPR1; Tectonin beta-propeller repeat-containing protein 1 Pleckstrin homology (PH) domain, repeat 1
    pfam00169
    Location:615 → 721
    PH; PH domain
    pfam06462
    Location:303 → 331
    Hyd_WA; Propeller

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    144131260..144160433 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504864.5 → XP_006504927.1  tectonin beta-propeller repeat-containing protein 1 isoform X1

    Conserved Domains (5) summary
    smart00694
    Location:762 → 795
    DysFC; Dysferlin domain, C-terminal region
    smart00693
    Location:690 → 751
    DysFN; Dysferlin domain, N-terminal region
    smart00706
    Location:103 → 139
    TECPR; Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins
    cd13300
    Location:478 → 598
    PH1_TECPR1; Tectonin beta-propeller repeat-containing protein 1 Pleckstrin homology (PH) domain, repeat 1
    pfam06462
    Location:171 → 200
    Hyd_WA; Propeller

  2. XM_036165488.1 → XP_036021381.1  tectonin beta-propeller repeat-containing protein 1 isoform X2

    Conserved Domains (5) summary
    smart00694
    Location:369 → 402
    DysFC; Dysferlin domain, C-terminal region
    smart00693
    Location:297 → 358
    DysFN; Dysferlin domain, N-terminal region
    smart00706
    Location:242 → 275
    TECPR; Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins
    cd13300
    Location:85 → 205
    PH1_TECPR1; Tectonin beta-propeller repeat-containing protein 1 Pleckstrin homology (PH) domain, repeat 1
    pfam19193
    Location:431 → 573
    Tectonin; Tectonin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80VP0.1 GenPept UniProtKB/Swiss-Prot:Q80VP0

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