Derl3 Der1-like domain family, member 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Derl3provided by MGI
Official Full Name: Der1-like domain family, member 3provided by MGI
Primary source: MGI:MGI:1917627
See related: Ensembl:ENSMUSG00000009092 AllianceGenome:MGI:1917627
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IZP6; derlin-3; 1810006I20Rik; 1810063P04Rik
Summary: Predicted to enable misfolded protein binding activity; signal recognition particle binding activity; and ubiquitin-specific protease binding activity. Predicted to be involved in cellular protein metabolic process; endoplasmic reticulum unfolded protein response; and negative regulation of retrograde protein transport, ER to cytosol. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Predicted to be part of Hrd1p ubiquitin ligase ERAD-L complex. Predicted to be integral component of endoplasmic reticulum membrane. Is expressed in several structures, including central nervous system; genitourinary system; liver; sensory organ; and spleen. Orthologous to human DERL3 (derlin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in ovary adult (RPKM 82.9), genital fat pad adult (RPKM 42.8) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 38.61 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (75729232..75731775)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (75893398..75895941)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Derlin-3 Is Required for Changes in ERAD Complex Formation under ER Stress.
Title: Derlin-3 Is Required for Changes in ERAD Complex Formation under ER Stress.
Derlin-1 deficiency is embryonic lethal, Derlin-3 deficiency appears normal, and Herp deficiency is intolerant to glucose load and ischemia in mice
Title: Derlin-1 deficiency is embryonic lethal, Derlin-3 deficiency appears normal, and Herp deficiency is intolerant to glucose load and ischemia in mice.
Study describes a potentially protective role for Derl3 in the heart.
Title: Roles for endoplasmic reticulum-associated degradation and the novel endoplasmic reticulum stress response gene Derlin-3 in the ischemic heart.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation
Targeted (1) 1 citation
Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables signal recognition particle binding	IBA Inferred from Biological aspect of Ancestor more info
enables signal recognition particle binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ERAD pathway	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum unfolded protein response	IBA Inferred from Biological aspect of Ancestor more info
involved_in endoplasmic reticulum unfolded protein response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of retrograde protein transport, ER to cytosol	ISO Inferred from Sequence Orthology more info
involved_in protein N-linked glycosylation via asparagine	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: derlin-3

Names: degradation in endoplasmic reticulum protein 3; der1-like protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.