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Ica1l islet cell autoantigen 1-like [ Mus musculus (house mouse) ]

Gene ID: 70375, updated on 21-Apr-2024

Summary

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Official Symbol
Ica1lprovided by MGI
Official Full Name
islet cell autoantigen 1-likeprovided by MGI
Primary source
MGI:MGI:1917625
See related
Ensembl:ENSMUSG00000026018 AllianceGenome:MGI:1917625
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Als2cr15; b2b3465Clo; 1700030B17Rik
Summary
Predicted to enable protein domain specific binding activity. Acts upstream of or within spermatid development. Located in acrosomal vesicle. Orthologous to human ICA1L (islet cell autoantigen 1 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 8.3), CNS E18 (RPKM 6.5) and 6 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 C2; 1 30.45 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (60024955..60082646, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (59985796..60043481, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene bone morphogenetic protein receptor type 2 Neighboring gene STARR-seq mESC enhancer starr_01055 Neighboring gene STARR-positive B cell enhancer ABC_E5760 Neighboring gene family with sequence similarity 117, member B Neighboring gene arginyl-tRNA synthetase 2, mitochondrial pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr1:60073097-60073398 Neighboring gene STARR-seq mESC enhancer starr_01058 Neighboring gene STARR-seq mESC enhancer starr_01059 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:60154934-60155145 Neighboring gene WD repeat domain 12 Neighboring gene calcium response factor Neighboring gene predicted gene 15464

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ICA1L forms BAR-domain complexes with PICK1 and is crucial for acrosome formation in spermiogenesis. He J, et al. J Cell Sci, 2015 Oct 15. PMID 26306493
  2. Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Li Y, et al. Nature, 2015 May 28. PMID 25807483, Free PMC Article
  3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ICA1L forms BAR-domain complexes with PICK1 and is crucial for acrosome formation in spermiogenesis.
    Title: ICA1L forms BAR-domain complexes with PICK1 and is crucial for acrosome formation in spermiogenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (4)  1 citation

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within spermatid development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in acrosomal vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
islet cell autoantigen 1-like protein
Names
Ica69-related protein
amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 15
amyotrophic lateral sclerosis 2 chromosomal region candidate gene 15 protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316694.2 → NP_001303623.1  islet cell autoantigen 1-like protein isoform a

    Status: VALIDATED

    Source sequence(s)
    AC125377
    Consensus CDS
    CCDS14987.1
    UniProtKB/Swiss-Prot
    Q3TY65, Q6AXB8, Q6PD23, Q8C0R6, Q9D9S5
    UniProtKB/TrEMBL
    A0A087WSM1
    Related
    ENSMUSP00000140520.2, ENSMUST00000191251.7
    Conserved Domains (2) summary
    pfam04629
    Location:254 → 431
    ICA69; Islet cell autoantigen ICA69, C-terminal domain
    pfam06456
    Location:15 → 242
    Arfaptin; Arfaptin-like domain

  2. NM_001316695.2 → NP_001303624.1  islet cell autoantigen 1-like protein isoform b

    Status: VALIDATED

    Source sequence(s)
    AC125377
    Related
    ENSMUST00000186970.2
    Conserved Domains (1) summary
    cl12013
    Location:15 → 84
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  3. NM_001357296.2 → NP_001344225.1  islet cell autoantigen 1-like protein isoform a

    Status: VALIDATED

    Source sequence(s)
    AC125377
    Consensus CDS
    CCDS14987.1
    UniProtKB/Swiss-Prot
    Q3TY65, Q6AXB8, Q6PD23, Q8C0R6, Q9D9S5
    UniProtKB/TrEMBL
    A0A087WSM1
    Conserved Domains (2) summary
    pfam04629
    Location:254 → 431
    ICA69; Islet cell autoantigen ICA69, C-terminal domain
    pfam06456
    Location:15 → 242
    Arfaptin; Arfaptin-like domain

  4. NM_027407.5 → NP_081683.3  islet cell autoantigen 1-like protein isoform a

    See identical proteins and their annotated locations for NP_081683.3

    Status: VALIDATED

    Source sequence(s)
    AC125377
    Consensus CDS
    CCDS14987.1
    UniProtKB/Swiss-Prot
    Q3TY65, Q6AXB8, Q6PD23, Q8C0R6, Q9D9S5
    UniProtKB/TrEMBL
    A0A087WSM1
    Related
    ENSMUSP00000027172.7, ENSMUST00000027172.13
    Conserved Domains (2) summary
    pfam04629
    Location:254 → 431
    ICA69; Islet cell autoantigen ICA69, C-terminal domain
    pfam06456
    Location:15 → 242
    Arfaptin; Arfaptin-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    60024955..60082646 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153607.1 → XP_036009500.1  islet cell autoantigen 1-like protein isoform X7

    Conserved Domains (2) summary
    pfam04629
    Location:327 → 365
    ICA69; Islet cell autoantigen ICA69, C-terminal domain
    cl12013
    Location:67 → 269
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  2. XM_036153596.1 → XP_036009489.1  islet cell autoantigen 1-like protein isoform X1

    UniProtKB/TrEMBL
    A0A087WSM1
    Conserved Domains (2) summary
    pfam04629
    Location:276 → 452
    ICA69; Islet cell autoantigen ICA69, C-terminal domain
    cl12013
    Location:67 → 269
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  3. XM_030242893.2 → XP_030098753.1  islet cell autoantigen 1-like protein isoform X2

    UniProtKB/TrEMBL
    A0A087WSM1
    Conserved Domains (2) summary
    pfam04629
    Location:248 → 425
    ICA69; Islet cell autoantigen ICA69, C-terminal domain
    pfam06456
    Location:15 → 236
    Arfaptin; Arfaptin-like domain

  4. XM_036153605.1 → XP_036009498.1  islet cell autoantigen 1-like protein isoform X5

    UniProtKB/TrEMBL
    A0A087WSM1
    Conserved Domains (2) summary
    pfam04629
    Location:255 → 414
    ICA69; Islet cell autoantigen ICA69, C-terminal domain
    cl12013
    Location:46 → 248
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  5. XM_017312240.3 → XP_017167729.1  islet cell autoantigen 1-like protein isoform X5

    UniProtKB/TrEMBL
    A0A087WSM1
    Conserved Domains (2) summary
    pfam04629
    Location:255 → 414
    ICA69; Islet cell autoantigen ICA69, C-terminal domain
    cl12013
    Location:46 → 248
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  6. XM_011238597.4 → XP_011236899.1  islet cell autoantigen 1-like protein isoform X4

    See identical proteins and their annotated locations for XP_011236899.1

    UniProtKB/Swiss-Prot
    Q3TY65, Q6AXB8, Q6PD23, Q8C0R6, Q9D9S5
    UniProtKB/TrEMBL
    A0A087WSM1
    Conserved Domains (2) summary
    pfam04629
    Location:254 → 431
    ICA69; Islet cell autoantigen ICA69, C-terminal domain
    pfam06456
    Location:15 → 242
    Arfaptin; Arfaptin-like domain

  7. XM_006496270.3 → XP_006496333.1  islet cell autoantigen 1-like protein isoform X4

    See identical proteins and their annotated locations for XP_006496333.1

    UniProtKB/Swiss-Prot
    Q3TY65, Q6AXB8, Q6PD23, Q8C0R6, Q9D9S5
    UniProtKB/TrEMBL
    A0A087WSM1
    Conserved Domains (2) summary
    pfam04629
    Location:254 → 431
    ICA69; Islet cell autoantigen ICA69, C-terminal domain
    pfam06456
    Location:15 → 242
    Arfaptin; Arfaptin-like domain

  8. XM_017312238.2 → XP_017167727.1  islet cell autoantigen 1-like protein isoform X2

    UniProtKB/TrEMBL
    A0A087WSM1
    Conserved Domains (2) summary
    pfam04629
    Location:248 → 425
    ICA69; Islet cell autoantigen ICA69, C-terminal domain
    pfam06456
    Location:15 → 236
    Arfaptin; Arfaptin-like domain

  9. XM_006496272.3 → XP_006496335.1  islet cell autoantigen 1-like protein isoform X9

    See identical proteins and their annotated locations for XP_006496335.1

    Conserved Domains (2) summary
    pfam04629
    Location:150 → 327
    ICA69; Islet cell autoantigen ICA69, C-terminal domain
    cl12013
    Location:1 → 144
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  10. XM_036153597.1 → XP_036009490.1  islet cell autoantigen 1-like protein isoform X3

    UniProtKB/TrEMBL
    A0A087WSM1
    Conserved Domains (2) summary
    pfam04629
    Location:276 → 435
    ICA69; Islet cell autoantigen ICA69, C-terminal domain
    cl12013
    Location:67 → 269
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  11. XM_030242896.2 → XP_030098756.1  islet cell autoantigen 1-like protein isoform X8

    Conserved Domains (2) summary
    pfam04629
    Location:310 → 344
    ICA69; Islet cell autoantigen ICA69, C-terminal domain
    cl12013
    Location:46 → 248
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  12. XM_030242895.1 → XP_030098755.1  islet cell autoantigen 1-like protein isoform X6

    UniProtKB/TrEMBL
    A0A087WSM1
    Conserved Domains (2) summary
    pfam04629
    Location:248 → 408
    ICA69; Islet cell autoantigen ICA69, C-terminal domain
    pfam06456
    Location:15 → 236
    Arfaptin; Arfaptin-like domain

  13. XM_030242894.2 → XP_030098754.1  islet cell autoantigen 1-like protein isoform X5

    UniProtKB/TrEMBL
    A0A087WSM1
    Related
    ENSMUSP00000141103.2, ENSMUST00000189776.2
    Conserved Domains (2) summary
    pfam04629
    Location:255 → 414
    ICA69; Islet cell autoantigen ICA69, C-terminal domain
    cl12013
    Location:46 → 248
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  14. XM_030242898.2 → XP_030098758.1  islet cell autoantigen 1-like protein isoform X10

    Conserved Domains (1) summary
    cl12013
    Location:15 → 84
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  15. XM_017312257.3 → XP_017167746.1  islet cell autoantigen 1-like protein isoform X10

    Conserved Domains (1) summary
    cl12013
    Location:15 → 84
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  16. XM_030242897.2 → XP_030098757.1  islet cell autoantigen 1-like protein isoform X10

    Conserved Domains (1) summary
    cl12013
    Location:15 → 84
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  17. XM_030242900.1 → XP_030098760.1  islet cell autoantigen 1-like protein isoform X10

    Conserved Domains (1) summary
    cl12013
    Location:15 → 84
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  18. XM_017312256.2 → XP_017167745.1  islet cell autoantigen 1-like protein isoform X10

    Conserved Domains (1) summary
    cl12013
    Location:15 → 84
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TY65.1 GenPept UniProtKB/Swiss-Prot:Q3TY65

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