Fbln7 fibulin 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fbln7provided by MGI
Official Full Name: fibulin 7provided by MGI
Primary source: MGI:MGI:1917620
See related: Ensembl:ENSMUSG00000027386 AllianceGenome:MGI:1917620
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TM14; 1600015H20Rik
Summary: Enables heparan sulfate proteoglycan binding activity and heparin binding activity. Acts upstream of or within positive regulation of biomineralization. Located in extracellular matrix and extracellular space. Is expressed in several structures, including alimentary system; brain; reproductive system; respiratory system; and skeleton. Orthologous to human FBLN7 (fibulin 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in placenta adult (RPKM 6.7), kidney adult (RPKM 6.3) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 F1; 2 62.63 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (128705791..128738954)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (128863865..128897034)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The extracellular matrix fibulin 7 maintains epidermal stem cell heterogeneity during skin aging.
Title: The extracellular matrix fibulin 7 maintains epidermal stem cell heterogeneity during skin aging.
Fibulin7 aggravates calcium oxalate-induced acute kidney injury by binding to calcium oxalate crystals.
Title: Fibulin7 aggravates calcium oxalate-induced acute kidney injury by binding to calcium oxalate crystals.
A C-terminal fragment of adhesion protein fibulin-7 inhibits growth of murine breast tumor by regulating macrophage reprogramming.
Title: A C-terminal fragment of adhesion protein fibulin-7 inhibits growth of murine breast tumor by regulating macrophage reprogramming.
This study examined the in vivo antiangiogenic activity of recombinant full-length mouse Fbln7 (Fbln7-FL) and Fbln7-C-Terminal Fragment proteins using a rat corneal angiogenesis model. Both Fbln7-FL and Fbln7-C inhibited neovascularization.
Title: Extracellular Protein Fibulin-7 and Its C-Terminal Fragment Have In Vivo Antiangiogenic Activity.
Results found that fibulin-7 is highly expressed in the adult kidney and binds heparin through its N-terminal domain. Fbln7-deficient mice were protected from renal tubular calcification and fibrosis after high phosphate diet. The study suggests that Fbln7 is a local mediator of calcium deposition in the kidney.
Title: Fibulin-7, a heparin binding matricellular protein, promotes renal tubular calcification in mice.
TM14 is a cell adhesion molecule that interacts with extracellular matrix molecules in teeth and suggest that TM14 plays important roles in both the differentiation and maintenance of odontoblasts as well as in dentin formation.
Title: TM14 is a new member of the fibulin family (fibulin-7) that interacts with extracellular matrix molecules and is active for cell binding.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (5) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables heparan sulfate proteoglycan binding	IDA Inferred from Direct Assay more info	PubMed
enables heparin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: fibulin-7

Names: FIBL-7; extracellular matrix protein TM14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024237.4 → NP_077199.2 fibulin-7 precursor

See identical proteins and their annotated locations for NP_077199.2

Status: VALIDATED

Source sequence(s)

AL808104, BB867118, BM936626, BX520805, CK023294

Consensus CDS

CCDS38235.1

UniProtKB/Swiss-Prot

Q501P1, Q9DAW5

Related

ENSMUSP00000028864.3, ENSMUST00000028864.3

Conserved Domains (5) summary

cd00033
Location:81 → 135

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

cd00054
Location:136 → 172

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam07645
Location:271 → 308

EGF_CA; Calcium-binding EGF domain

pfam12662
Location:251 → 274

cEGF; Complement Clr-like EGF-like

cl00057
Location:221 → 268

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

128705791..128738954

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006500157.5 → XP_006500220.1 fibulin-7 isoform X1

Conserved Domains (5) summary

cd00033
Location:81 → 135

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

cd00054
Location:136 → 172

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam07645
Location:271 → 308

EGF_CA; Calcium-binding EGF domain

pfam12662
Location:251 → 274

cEGF; Complement Clr-like EGF-like

cl00057
Location:221 → 268

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...