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Kcnip1 Kv channel-interacting protein 1 [ Mus musculus (house mouse) ]

Gene ID: 70357, updated on 21-Apr-2024

Summary

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Official Symbol
Kcnip1provided by MGI
Official Full Name
Kv channel-interacting protein 1provided by MGI
Primary source
MGI:MGI:1917607
See related
Ensembl:ENSMUSG00000053519 AllianceGenome:MGI:1917607
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KCHIP1; Kchip1.2
Summary
Predicted to enable several functions, including calcium ion binding activity; protein N-terminus binding activity; and transmembrane transporter binding activity. Predicted to be involved in positive regulation of action potential and regulation of potassium ion transmembrane transport. Predicted to act upstream of or within potassium ion transmembrane transport and regulation of ion transmembrane transport. Part of voltage-gated potassium channel complex. Is expressed in several structures, including brain; ganglia; intestine smooth muscle circular layer; spinal cord; and testis. Orthologous to human KCNIP1 (potassium voltage-gated channel interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 12.1), CNS E18 (RPKM 11.7) and 8 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 A4; 11 19.21 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (33579339..33943854, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (33629339..33993348, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_29136 Neighboring gene RIKEN cDNA D130052B06 gene Neighboring gene gamma-aminobutyric acid type A receptor subunit pi Neighboring gene predicted gene 12119 Neighboring gene STARR-seq mESC enhancer starr_29137 Neighboring gene STARR-seq mESC enhancer starr_29138 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:33819926-33820148 Neighboring gene STARR-positive B cell enhancer ABC_E8390 Neighboring gene predicted gene, 39677 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:33838922-33839284 Neighboring gene RIKEN cDNA 4930469K13 gene Neighboring gene predicted gene, 36395 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:33908807-33908990 Neighboring gene potassium large conductance calcium-activated channel, subfamily M, beta member 1 Neighboring gene predicted gene, 51857 Neighboring gene predicted gene, 53680 Neighboring gene STARR-seq mESC enhancer starr_29140 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:33964098-33964329 Neighboring gene lymphocyte cytosolic protein 2 Neighboring gene predicted gene 12121

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Roles of KChIP1 in the regulation of GABA-mediated transmission and behavioral anxiety. Xia K, et al. Mol Brain, 2010 Aug 2. PMID 20678225, Free PMC Article
  2. KChIP1: a potential modulator to GABAergic system. Xiong H, et al. Acta Biochim Biophys Sin (Shanghai), 2009 Apr. PMID 19352544
  3. The aromatic cluster in KCHIP1b affects Kv4 inactivation gating. Van Hoorick D, et al. J Physiol, 2007 Sep 15. PMID 17640927, Free PMC Article
  4. Differential modulation of Kv4 kinetics by KCHIP1 splice variants. Van Hoorick D, et al. Mol Cell Neurosci, 2003 Oct. PMID 14572458
  5. Differential distribution of KChIPs mRNAs in adult mouse brain. Xiong H, et al. Brain Res Mol Brain Res, 2004 Sep 28. PMID 15363885

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. KChIP1 is a synaptic protein that regulates behavioral anxiety by modulating inhibitory synaptic transmission.
    Title: Roles of KChIP1 in the regulation of GABA-mediated transmission and behavioral anxiety.
  2. KChIP1 deletion showed increased susceptibility to anti-GABAergic convulsive drug pentylenetetrazole-induced seizure, indicating that KChIP1 might play pivotal roles in the GABAergic inhibitory system.
    Title: KChIP1: a potential modulator to GABAergic system.
  3. aromatic cluster in exon1b modulates the transitions towards and from the closed inactivated states and the steady state distribution over the respective states
    Title: The aromatic cluster in KCHIP1b affects Kv4 inactivation gating.
  4. KChIP1 was expressed in a subpopulation of neurons widely distributed in brain and enriched in Purkinje cells of the cerebellum and in the reticular thalamic and medial habenular nuclei.
    Title: Differential distribution of KChIPs mRNAs in adult mouse brain.
  5. Differential expression of KCh1P1 splice variants can shape the function of Kv4.2 channels involved in protection against back propagating action potentials in dendritic spines.
    Title: Differential modulation of Kv4 kinetics by KCHIP1 splice variants.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Clone Names

  • 2900046L02Rik, 3202002F18Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables potassium channel regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane transporter binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of action potential ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of potassium channel complex ISO
Inferred from Sequence Orthology
more info
  
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated potassium channel complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
Kv channel-interacting protein 1
Names
A-type potassium channel modulatory protein 1
A-type potassium channel modulatory protein 1.2
potassium channel-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190885.3 → NP_001177814.1  Kv channel-interacting protein 1 isoform A

    See identical proteins and their annotated locations for NP_001177814.1

    Status: VALIDATED

    Source sequence(s)
    AL669814, AL731867
    Consensus CDS
    CCDS56766.1
    UniProtKB/Swiss-Prot
    Q5SSA3, Q6DTJ1, Q8BGJ4, Q8C4K4, Q8CGL1, Q8K1U1, Q8K3M2, Q9JJ57
    UniProtKB/TrEMBL
    Q3YAB4
    Related
    ENSMUSP00000104964.3, ENSMUST00000109340.9
    Conserved Domains (1) summary
    COG5126
    Location:50 → 216
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  2. NM_001190886.2 → NP_001177815.1  Kv channel-interacting protein 1 isoform C

    See identical proteins and their annotated locations for NP_001177815.1

    Status: VALIDATED

    Source sequence(s)
    AL669814, AL731867
    Consensus CDS
    CCDS88143.1
    UniProtKB/TrEMBL
    A0A571BET8, Q3YAB5
    Related
    ENSMUSP00000158966.2, ENSMUST00000238903.2
    Conserved Domains (2) summary
    COG5126
    Location:48 → 214
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00051
    Location:135 → 206
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  3. NM_001290690.3 → NP_001277619.1  Kv channel-interacting protein 1 isoform D

    See identical proteins and their annotated locations for NP_001277619.1

    Status: VALIDATED

    Source sequence(s)
    AL669814, AL731867
    Consensus CDS
    CCDS70160.1
    UniProtKB/TrEMBL
    Q3YAB4
    Related
    ENSMUSP00000098919.3, ENSMUST00000101368.9
    Conserved Domains (1) summary
    COG5126
    Location:11 → 177
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  4. NM_001363115.2 → NP_001350044.1  Kv channel-interacting protein 1 isoform E

    Status: VALIDATED

    Source sequence(s)
    AL662902, AL669814
    UniProtKB/TrEMBL
    A0A571BET8
    Related
    ENSMUSP00000158813.2, ENSMUST00000238436.2
    Conserved Domains (1) summary
    COG5126
    Location:68 → 234
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  5. NM_027398.5 → NP_081674.2  Kv channel-interacting protein 1 isoform B

    See identical proteins and their annotated locations for NP_081674.2

    Status: VALIDATED

    Source sequence(s)
    AL669814, AL731867
    Consensus CDS
    CCDS24537.1
    UniProtKB/TrEMBL
    Q3YAB4, Q3YAB6
    Related
    ENSMUSP00000069063.6, ENSMUST00000065970.6
    Conserved Domains (1) summary
    COG5126
    Location:39 → 205
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    33579339..33943854 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314753.3 → XP_017170242.1  Kv channel-interacting protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A571BET8
    Conserved Domains (1) summary
    COG5126
    Location:48 → 218
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  2. XM_036156977.1 → XP_036012870.1  Kv channel-interacting protein 1 isoform X6

    UniProtKB/TrEMBL
    Q3YAB4
    Conserved Domains (1) summary
    COG5126
    Location:11 → 177
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  3. XM_036156976.1 → XP_036012869.1  Kv channel-interacting protein 1 isoform X6

    UniProtKB/TrEMBL
    Q3YAB4
    Conserved Domains (1) summary
    COG5126
    Location:11 → 177
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  4. XM_017314754.2 → XP_017170243.1  Kv channel-interacting protein 1 isoform X4

    UniProtKB/TrEMBL
    Q3YAB4
    Conserved Domains (1) summary
    COG5126
    Location:39 → 209
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  5. XM_017314752.2 → XP_017170241.1  Kv channel-interacting protein 1 isoform X2

    UniProtKB/TrEMBL
    Q3YAB4
    Conserved Domains (1) summary
    COG5126
    Location:50 → 220
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  6. XM_030246299.1 → XP_030102159.1  Kv channel-interacting protein 1 isoform X6

    UniProtKB/TrEMBL
    Q3YAB4
    Conserved Domains (1) summary
    COG5126
    Location:11 → 177
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  7. XM_030246297.1 → XP_030102157.1  Kv channel-interacting protein 1 isoform X6

    UniProtKB/TrEMBL
    Q3YAB4
    Conserved Domains (1) summary
    COG5126
    Location:11 → 177
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  8. XM_017314755.3 → XP_017170244.1  Kv channel-interacting protein 1 isoform X5

    UniProtKB/TrEMBL
    Q3YAB4
    Conserved Domains (1) summary
    COG5126
    Location:11 → 181
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  9. XM_030246298.2 → XP_030102158.1  Kv channel-interacting protein 1 isoform X6

    UniProtKB/TrEMBL
    Q3YAB4
    Conserved Domains (1) summary
    COG5126
    Location:11 → 177
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  10. XM_017314751.3 → XP_017170240.1  Kv channel-interacting protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A571BET8
    Conserved Domains (1) summary
    COG5126
    Location:68 → 238
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  11. XM_036156978.1 → XP_036012871.1  Kv channel-interacting protein 1 isoform X6

    UniProtKB/TrEMBL
    Q3YAB4
    Conserved Domains (1) summary
    COG5126
    Location:11 → 177
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JJ57.2 GenPept UniProtKB/Swiss-Prot:Q9JJ57

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