Iyd iodotyrosine deiodinase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Iydprovided by MGI
Official Full Name: iodotyrosine deiodinaseprovided by MGI
Primary source: MGI:MGI:1917587
See related: Ensembl:ENSMUSG00000019762 AllianceGenome:MGI:1917587
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IYD-1; Dehal1; 0610009A07Rik
Summary: Enables iodotyrosine deiodinase activity. Predicted to be involved in thyroid hormone metabolic process and tyrosine metabolic process. Predicted to be located in cytoplasmic vesicle membrane; nucleoplasm; and plasma membrane. Predicted to be integral component of plasma membrane. Is expressed in thyroid gland. Human ortholog(s) of this gene implicated in thyroid dyshormonogenesis 4. Orthologous to human IYD (iodotyrosine deiodinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver adult (RPKM 19.2), kidney adult (RPKM 11.0) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 A1; 10 2.06 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (3490274..3504880)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (3540274..3554880)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

At least for Metazoa, IYD should provide a new marker for tracing the evolutionary development of iodinated amino acids as regulatory signals through the tree of life.
Title: Iodotyrosine deiodinase: a unique flavoprotein present in organisms of diverse phyla.
Data show that the structures provide a molecular basis for understanding thyroid disease based on mutations of IYD.
Title: Crystal structure of iodotyrosine deiodinase, a novel flavoprotein responsible for iodide salvage in thyroid glands.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables FMN binding	IDA Inferred from Direct Assay more info	PubMed
enables FMN binding	ISO Inferred from Sequence Orthology more info
enables iodotyrosine deiodinase activity	IDA Inferred from Direct Assay more info	PubMed
enables iodotyrosine deiodinase activity	ISA Inferred from Sequence Alignment more info	PubMed
enables iodotyrosine deiodinase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in thyroid hormone metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in thyroid hormone metabolic process	ISO Inferred from Sequence Orthology more info
involved_in tyrosine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in tyrosine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in tyrosine metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: iodotyrosine deiodinase 1

Names: iodotyrosine dehalogenase 1 protein

NP_081667.1

EC 1.21.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027391.4 → NP_081667.1 iodotyrosine deiodinase 1

See identical proteins and their annotated locations for NP_081667.1

Status: VALIDATED

Source sequence(s)

AC153571, AC155833

Consensus CDS

CCDS56670.1

UniProtKB/Swiss-Prot

Q9DCX8

Related

ENSMUSP00000019896.5, ENSMUST00000019896.5

Conserved Domains (1) summary

cd02144
Location:89 → 281

iodotyrosine_dehalogenase; Iodotyrosine dehalogenase catalyzes the removal of iodine from the 3, 5 positions of L-tyosine in thyroid, liver and kidney, using NADPH as electron donor. This enzyme is a homolog of the nitroreductase family. These enzymes are usually homodimers.