Ndufab1 NADH:ubiquinone oxidoreductase subunit AB1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ndufab1provided by MGI
Official Full Name: NADH:ubiquinone oxidoreductase subunit AB1provided by MGI
Primary source: MGI:MGI:1917566
See related: Ensembl:ENSMUSG00000030869 AllianceGenome:MGI:1917566
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ACP; 8kDa; SDAP; CI-SDAP; 2210401F17Rik; 2310039H15Rik; 2610003B19Rik; 9130423F15Rik
Summary: Predicted to enable acyl binding activity and acyl carrier activity. Predicted to be involved in mitochondrial respiratory chain complex I assembly and protein lipoylation. Predicted to act upstream of or within fatty acid metabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human NDUFAB1 (NADH:ubiquinone oxidoreductase subunit AB1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in adrenal adult (RPKM 768.6), duodenum adult (RPKM 586.0) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F2; 7 65.38 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (121686038..121701071, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (122086815..122101848, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Skeletal muscle-specific ablation of NDUFAB1 disrupts glucose homeostasis and results in obesity and insulin resistance.
Title: NDUFAB1 protects against obesity and insulin resistance by enhancing mitochondrial metabolism.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:493062

px-31f3 (e-PCR)
- UniSTS:257585

Ndufab1 (e-PCR), detects polymorphism
- UniSTS:527439

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables acyl binding	IBA Inferred from Biological aspect of Ancestor more info
enables acyl carrier activity	IBA Inferred from Biological aspect of Ancestor more info
enables mitochondrial large ribosomal subunit binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in [2Fe-2S] cluster assembly	ISO Inferred from Sequence Orthology more info
involved_in aerobic respiration	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in iron-sulfur cluster assembly	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial respiratory chain complex I assembly	ISO Inferred from Sequence Orthology more info
involved_in protein lipoylation	ISO Inferred from Sequence Orthology more info
involved_in proton motive force-driven mitochondrial ATP synthesis	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of iron-sulfur cluster assembly complex	NAS Non-traceable Author Statement more info	PubMed
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
part_of mitochondrial respiratory chain complex I	IBA Inferred from Biological aspect of Ancestor more info
part_of mitochondrial respiratory chain complex I	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	NAS Non-traceable Author Statement more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in respirasome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: acyl carrier protein, mitochondrial

Names: NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1; NADH-ubiquinone oxidoreductase 9.6 kDa subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001360743.1 → NP_001347672.1 acyl carrier protein, mitochondrial precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same protein.

Source sequence(s)

AC124379, BF019966

Consensus CDS

CCDS21809.1

UniProtKB/Swiss-Prot

Q9CR21, Q9D726, Q9D7V5

UniProtKB/TrEMBL

Q3TJG2, Q569N0

Related

ENSMUSP00000102079.3, ENSMUST00000106471.9

Conserved Domains (1) summary

cl09936
Location:66 → 152

PP-binding; Phosphopantetheine attachment site
NM_001360744.1 → NP_001347673.1 acyl carrier protein, mitochondrial precursor

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 3' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same protein.

Source sequence(s)

AC124379, AK010307

Consensus CDS

CCDS21809.1

UniProtKB/Swiss-Prot

Q9CR21, Q9D726, Q9D7V5

UniProtKB/TrEMBL

Q3TJG2, Q569N0

Related

ENSMUSP00000116177.2, ENSMUST00000123296.8

Conserved Domains (1) summary

cl09936
Location:66 → 152

PP-binding; Phosphopantetheine attachment site
NM_028177.4 → NP_082453.2 acyl carrier protein, mitochondrial precursor

See identical proteins and their annotated locations for NP_082453.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 all encode the same protein.

Source sequence(s)

AC124379, AK011302

Consensus CDS

CCDS21809.1

UniProtKB/Swiss-Prot

Q9CR21, Q9D726, Q9D7V5

UniProtKB/TrEMBL

Q3TJG2, Q569N0

Related

ENSMUSP00000033157.4, ENSMUST00000033157.10

Conserved Domains (1) summary

cl09936
Location:66 → 152

PP-binding; Phosphopantetheine attachment site

RNA

NR_153798.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks an alternate exon and differs in the 3' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC124379