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Hdac8 histone deacetylase 8 [ Mus musculus (house mouse) ]

Gene ID: 70315, updated on 16-Apr-2024

Summary

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Official Symbol
Hdac8provided by MGI
Official Full Name
histone deacetylase 8provided by MGI
Primary source
MGI:MGI:1917565
See related
Ensembl:ENSMUSG00000067567 AllianceGenome:MGI:1917565
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2610007D20Rik
Summary
Predicted to enable chromatin binding activity; heat shock protein binding activity; and histone deacetylase activity. Predicted to be involved in several processes, including histone deacetylation; negative regulation of macromolecule metabolic process; and regulation of chromosome organization. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be part of histone deacetylase complex. Is expressed in several structures, including 2-cell stage embryo; brain; embryo ectoderm; foregut; and retina. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 5 and Wilson-Turner syndrome. Orthologous to human HDAC8 (histone deacetylase 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 1.2), bladder adult (RPKM 1.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Hdac8 in Genome Data Viewer
Location:
X D; X 45.28 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (101328244..101549005, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (102284638..102505381, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1 Neighboring gene predicted gene 14858 Neighboring gene STARR-seq mESC enhancer starr_47671 Neighboring gene predicted gene, 32262 Neighboring gene STARR-seq mESC enhancer starr_47673 Neighboring gene phosphorylase kinase alpha 1 Neighboring gene STARR-seq mESC enhancer starr_47674 Neighboring gene STARR-seq mESC enhancer starr_47675 Neighboring gene transcriptional adaptor 3 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Histone deacetylase 8 regulates NF-κB-related inflammation in asthmatic mice through H3K9 acetylation. Ren Y, et al. Chin Med J (Engl), 2022 Sep 5. PMID 35170504, Free PMC Article
  2. Histone-deacetylase 8 drives the immune response and the growth of glioma. Mormino A, et al. Glia, 2021 Nov. PMID 34310727, Free PMC Article
  3. Identification of histone deacetylase 8 as a novel therapeutic target for renal fibrosis. Zhang Y, et al. FASEB J, 2020 Jun. PMID 32281211, Free PMC Article
  4. Oocyte-specific deletion of Hdac8 in mice reveals stage-specific effects on fertility. Singh VP, et al. Reproduction, 2019 Mar. PMID 30620721
  5. HDAC8 regulates neural differentiation through embryoid body formation in P19 cells. Katayama S, et al. Biochem Biophys Res Commun, 2018 Mar 25. PMID 29499194

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inhibition of HDAC8 Reduces the Proliferation of Adult Neural Stem Cells in the Subventricular Zone.
    Title: Inhibition of HDAC8 Reduces the Proliferation of Adult Neural Stem Cells in the Subventricular Zone.
  2. Histone deacetylase 8 inhibition prevents the progression of peritoneal fibrosis by counteracting the epithelial-mesenchymal transition and blockade of M2 macrophage polarization.
    Title: Histone deacetylase 8 inhibition prevents the progression of peritoneal fibrosis by counteracting the epithelial-mesenchymal transition and blockade of M2 macrophage polarization.
  3. Histone deacetylase 8 regulates NF-kappaB-related inflammation in asthmatic mice through H3K9 acetylation.
    Title: Histone deacetylase 8 regulates NF-κB-related inflammation in asthmatic mice through H3K9 acetylation.
  4. Histone-deacetylase 8 drives the immune response and the growth of glioma.
    Title: Histone-deacetylase 8 drives the immune response and the growth of glioma.
  5. MiR-451a ameliorates alcoholic hepatitis via repressing HDAC8-mediated proinflammatory response.
    Title: MiR-451a ameliorates alcoholic hepatitis via repressing HDAC8-mediated proinflammatory response.
  6. Identification of histone deacetylase 8 as a novel therapeutic target for renal fibrosis.
    Title: Identification of histone deacetylase 8 as a novel therapeutic target for renal fibrosis.
  7. The activity of HDAC2 and HDAC8 was elevated 7 days after the ischemia both in neurons and astrocytes of the studied brain structures.
    Title: Expression of Class I Histone Deacetylases in Ipsilateral and Contralateral Hemispheres after the Focal Photothrombotic Infarction in the Mouse Brain.
  8. HDAC8 regulates neural differentiation by exerting control of embryoid body formation.
    Title: HDAC8 regulates neural differentiation through embryoid body formation in P19 cells.
  9. Results indicate that HDAC8 functions to modulate p53 activity to ensure long-term hematopoietic stem cells (LT-HSCs) maintenance and cell survival under stress.
    Title: HDAC8 regulates long-term hematopoietic stem-cell maintenance under stress by modulating p53 activity.
  10. The findings suggest that miR-455-3p plays a critical role during chondrogenesis by directly targeting HDAC2/8 and promoting histone H3 acetylation.
    Title: MicroRNA-455-3p modulates cartilage development and degeneration through modification of histone H3 acetylation.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor binding TAS
Traceable Author Statement
more info
 PubMed 
enables Hsp70 protein binding ISO
Inferred from Sequence Orthology
more info
  
enables Hsp90 protein binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables deacetylase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone deacetylase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone deacetylase activity TAS
Traceable Author Statement
more info
 PubMed 
enables histone decrotonylase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein lysine deacetylase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to forskolin ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to trichostatin A ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin organization TAS
Traceable Author Statement
more info
 PubMed 
involved_in epigenetic regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic sister chromatid cohesion ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein modification process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein stability ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of telomere maintenance ISO
Inferred from Sequence Orthology
more info
  
involved_in response to 11-deoxycorticosterone ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm TAS
Traceable Author Statement
more info
 PubMed 
part_of histone deacetylase complex TAS
Traceable Author Statement
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
histone deacetylase 8
Names
HD8
protein deacetylase HDAC8
protein decrotonylase HDAC8
NP_001300671.1
NP_081658.1
XP_006528338.1
XP_006528339.1
XP_011245973.1
XP_011245975.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313742.1 → NP_001300671.1  histone deacetylase 8 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several exons and includes an alternate 3' terminal exon compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK034511, AK131998
    UniProtKB/Swiss-Prot
    Q8VH37
    Related
    ENSMUST00000148481.8
    Conserved Domains (1) summary
    cl17011
    Location:16 → 246
    Arginase_HDAC; Arginase-like and histone-like hydrolases

  2. NM_027382.4 → NP_081658.1  histone deacetylase 8 isoform 1

    See identical proteins and their annotated locations for NP_081658.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK131998, AL954850
    Consensus CDS
    CCDS41084.1
    UniProtKB/Swiss-Prot
    Q3V270, Q8VH37, Q9D0K6
    Related
    ENSMUSP00000085226.5, ENSMUST00000087916.11
    Conserved Domains (1) summary
    cd10000
    Location:16 → 377
    HDAC8; Histone deacetylase 8 (HDAC8)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    101328244..101549005 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006528276.5 → XP_006528339.1  histone deacetylase 8 isoform X2

    Conserved Domains (1) summary
    cd10000
    Location:16 → 335
    HDAC8; Histone deacetylase 8 (HDAC8)

  2. XM_006528275.5 → XP_006528338.1  histone deacetylase 8 isoform X1

    Conserved Domains (1) summary
    cd10000
    Location:16 → 370
    HDAC8; Histone deacetylase 8 (HDAC8)

  3. XM_011247671.4 → XP_011245973.1  histone deacetylase 8 isoform X3

    Conserved Domains (1) summary
    cd10000
    Location:16 → 335
    HDAC8; Histone deacetylase 8 (HDAC8)

  4. XM_011247673.4 → XP_011245975.1  histone deacetylase 8 isoform X4

    Conserved Domains (1) summary
    cl17011
    Location:16 → 153
    Arginase_HDAC; Arginase-like and histone-like hydrolases

RNA

  1. XR_004940364.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VH37.2 GenPept UniProtKB/Swiss-Prot:Q8VH37

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