U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Gcc2 GRIP and coiled-coil domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 70297, updated on 23-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Gcc2provided by MGI
Official Full Name
GRIP and coiled-coil domain containing 2provided by MGI
Primary source
MGI:MGI:1917547
See related
Ensembl:ENSMUSG00000038039 AllianceGenome:MGI:1917547
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0336; 0610043A03Rik; 2210420P05Rik; 2600014C01Rik
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in several processes, including microtubule cytoskeleton organization; protein localization to organelle; and retrograde transport, endosome to Golgi. Predicted to act upstream of or within protein transport. Predicted to be located in nucleoplasm and trans-Golgi network. Predicted to be active in Golgi apparatus. Orthologous to human GCC2 (GRIP and coiled-coil domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 5.2), frontal lobe adult (RPKM 5.1) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
10 B4; 10 29.3 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (58091240..58141421)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (58255408..58305599)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2935 Neighboring gene double homeobox family member 4 Neighboring gene double homeobox family member 5 Neighboring gene STARR-positive B cell enhancer ABC_E575 Neighboring gene STARR-seq mESC enhancer starr_26754 Neighboring gene LIM and senescent cell antigen-like domains 1 Neighboring gene STARR-positive B cell enhancer ABC_E6854 Neighboring gene predicted gene, 23058 Neighboring gene STARR-positive B cell enhancer ABC_E2936 Neighboring gene RAN binding protein 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Evolutionary conservation of a coding function for D4Z4, the tandem DNA repeat mutated in facioscapulohumeral muscular dystrophy. Clapp J, et al. Am J Hum Genet, 2007 Aug. PMID 17668377, Free PMC Article
  2. Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2002 Oct 31. PMID 12465718
  3. Bioinformatics and cellular signaling. Papin J, et al. Curr Opin Biotechnol, 2004 Feb. PMID 15102471
  4. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
  5. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi ribbon formation ISO
Inferred from Sequence Orthology
more info
  
involved_in late endosome to Golgi transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in late endosome to Golgi transport ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule anchoring ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule organizing center organization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
involved_in protein targeting to lysosome ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in recycling endosome to Golgi transport ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein exit from endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
involved_in retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
GRIP and coiled-coil domain-containing protein 2
Names
185 kDa Golgi coiled-coil protein
GCC185

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027375.3 → NP_081651.2  GRIP and coiled-coil domain-containing protein 2

    See identical proteins and their annotated locations for NP_081651.2

    Status: VALIDATED

    Source sequence(s)
    AC170751
    Consensus CDS
    CCDS23859.1
    UniProtKB/Swiss-Prot
    B2RSU7, Q8BR44, Q8CHG3, Q8R2Q5, Q9CT45
    UniProtKB/TrEMBL
    E9PWI6
    Related
    ENSMUSP00000054033.8, ENSMUST00000057659.14
    Conserved Domains (4) summary
    TIGR02168
    Location:624 → 1386
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01465
    Location:1610 → 1652
    GRIP; GRIP domain
    pfam07851
    Location:104 → 203
    TMPIT; TMPIT-like protein
    pfam16704
    Location:1544 → 1608
    Rab_bind; Rab binding domain

RNA

  1. NR_176435.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC170751

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    58091240..58141421
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155993.1 → XP_036011886.1  GRIP and coiled-coil domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    E0CYI9
    Related
    ENSMUSP00000124152.2, ENSMUST00000162860.8
    Conserved Domains (4) summary
    COG1196
    Location:227 → 1044
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:654 → 1370
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam16704
    Location:1444 → 1508
    Rab_bind; Rab binding domain
    pfam01465
    Location:1510 → 1552
    GRIP; GRIP domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CHG3.3 GenPept UniProtKB/Swiss-Prot:Q8CHG3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous