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Ly6g6e lymphocyte antigen 6 family member G6E [ Mus musculus (house mouse) ]

Gene ID: 70274, updated on 8-Feb-2024

Summary

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Official Symbol
Ly6g6eprovided by MGI
Official Full Name
lymphocyte antigen 6 family member G6Eprovided by MGI
Primary source
MGI:MGI:1917524
See related
Ensembl:ENSMUSG00000013766 AllianceGenome:MGI:1917524
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
G6e; 2310011I02Rik
Summary
Enables acetylcholine receptor activator activity and acetylcholine receptor binding activity. Acts upstream of or within acetylcholine receptor signaling pathway and desensitization of G protein-coupled receptor signaling pathway. Located in plasma membrane. Is expressed in embryo; liver; lung; metanephros; and testis. Orthologous to human LY6G6E (lymphocyte antigen 6 family member G6E). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in stomach adult (RPKM 36.3), colon adult (RPKM 18.8) and 8 other tissues See more
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Genomic context

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Location:
17 B1; 17 18.59 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35295843..35297781)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (35076868..35078804)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene megakaryocyte and platelet inhibitory receptor G6b Neighboring gene G6b opposite strand Neighboring gene lymphocyte antigen 6 family member G6C Neighboring gene lymphocyte antigen 6 family member G6D Neighboring gene STARR-seq mESC enhancer starr_42446 Neighboring gene lymphocyte antigen 6 family member G6F Neighboring gene STARR-positive B cell enhancer ABC_E7527 Neighboring gene abhydrolase domain containing 16A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Transcriptional analysis of a novel cluster of LY-6 family members in the human and mouse major histocompatibility complex: five genes with many splice forms. Mallya M, et al. Genomics, 2002 Jul. PMID 12079290
  2. Mechanisms of inhibition and potentiation of α4β2 nicotinic acetylcholine receptors by members of the Ly6 protein family. Wu M, et al. J Biol Chem, 2015 Oct 2. PMID 26276394, Free PMC Article
  3. Characterization of the five novel Ly-6 superfamily members encoded in the MHC, and detection of cells expressing their potential ligands. Mallya M, et al. Protein Sci, 2006 Oct. PMID 17008713, Free PMC Article
  4. A microarray analysis of the XX Wnt4 mutant gonad targeted at the identification of genes involved in testis vascular differentiation. Coveney D, et al. Gene Expr Patterns, 2007 Jan. PMID 16844427
  5. Organization, evolution and functions of the human and mouse Ly6/uPAR family genes. Loughner CL, et al. Hum Genomics, 2016 Apr 21. PMID 27098205, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lynx2 and Ly6g6e have roles in intracellular trafficking and allosteric potentiation of alpha4beta2 nAChRs, respectively
    Title: Mechanisms of inhibition and potentiation of α4β2 nicotinic acetylcholine receptors by members of the Ly6 protein family.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acetylcholine receptor activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetylcholine receptor activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acetylcholine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetylcholine receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane receptor protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in acetylcholine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within acetylcholine receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in desensitization of G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within desensitization of G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
lymphocyte antigen 6G6e
Names
lymphocyte antigen 6 complex G6E
lymphocyte antigen 6 complex locus protein G6e
lymphocyte antigen 6 complex, locus G6E

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001405155.1 → NP_001392084.1  lymphocyte antigen 6G6e isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AC087117
    Related
    ENSMUSP00000134073.2, ENSMUST00000172678.8

  2. NM_001405156.1 → NP_001392085.1  lymphocyte antigen 6G6e isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AC087117

  3. NM_001405157.1 → NP_001392086.1  lymphocyte antigen 6G6e isoform b precursor

    Status: VALIDATED

    Source sequence(s)
    AC087117
    UniProtKB/TrEMBL
    G3UXD4
    Related
    ENSMUSP00000133645.2, ENSMUST00000172494.8

  4. NM_027366.2 → NP_081642.1  lymphocyte antigen 6G6e isoform a precursor

    See identical proteins and their annotated locations for NP_081642.1

    Status: VALIDATED

    Source sequence(s)
    AC087117
    Consensus CDS
    CCDS28679.1
    UniProtKB/Swiss-Prot
    Q8K1T6
    Related
    ENSMUSP00000013910.5, ENSMUST00000013910.5
    Conserved Domains (1) summary
    pfam01064
    Location:28 → 104
    Activin_recp; Activin types I and II receptor domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    35295843..35297781
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524887.5 → XP_006524950.1  lymphocyte antigen 6G6e isoform X1

    See identical proteins and their annotated locations for XP_006524950.1

    UniProtKB/Swiss-Prot
    Q8K1T6, Q9D7E5
    Conserved Domains (1) summary
    pfam01064
    Location:28 → 136
    Activin_recp; Activin types I and II receptor domain

  2. XM_006524886.4 → XP_006524949.1  lymphocyte antigen 6G6e isoform X1

    See identical proteins and their annotated locations for XP_006524949.1

    UniProtKB/Swiss-Prot
    Q8K1T6, Q9D7E5
    Conserved Domains (1) summary
    pfam01064
    Location:28 → 136
    Activin_recp; Activin types I and II receptor domain

  3. XM_030250043.1 → XP_030105903.1  lymphocyte antigen 6G6e isoform X1

    UniProtKB/Swiss-Prot
    Q8K1T6, Q9D7E5
    Related
    ENSMUSP00000133753.2, ENSMUST00000172959.2
    Conserved Domains (1) summary
    pfam01064
    Location:28 → 136
    Activin_recp; Activin types I and II receptor domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001003720.1: Suppressed sequence

    Description
    NM_001003720.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K1T6.1 GenPept UniProtKB/Swiss-Prot:Q8K1T6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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